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公开(公告)号：US07915253B2
公开(公告)日：2011-03-29
申请号：US12204459
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen K. Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen K. Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
IPC分类号： A61K31/496 , A61K31/4418 , A61K31/551 , A61K31/495 , C07D241/04 , C07D401/04 , C07D211/70 , C07D401/12 , C07D409/14
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号：US20090029971A1
公开(公告)日：2009-01-29
申请号：US12204459
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
IPC分类号： A61K31/496 , C07D241/04 , C07D401/04 , C07D211/70 , A61K31/4418 , A61K31/551 , A61K31/495 , C07D401/12 , C07D409/14
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号：US07834004B2
公开(公告)日：2010-11-16
申请号：US12204489
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
IPC分类号： A61K31/496 , A61K31/343 , A61K31/404 , A61K31/551 , A61K31/495 , C07D333/52 , C07D403/02 , C07D209/04 , C07D405/02 , C07D307/78
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号：US20090264417A1
公开(公告)日：2009-10-22
申请号：US12204489
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
IPC分类号： A61K31/551 , C07D295/26 , A61K31/495 , A61K31/496 , C07K1/107 , C07D401/04 , C07D403/12
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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公开(公告)号：US07494999B2
公开(公告)日：2009-02-24
申请号：US11258463
申请日：2005-10-25
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
IPC分类号： A61K31/4965 , C07D241/04
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号：US20090227599A1
公开(公告)日：2009-09-10
申请号：US12396513
申请日：2009-03-03
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Sergio G. Duron , Andrew K. Lindstrom , Andrew K. Shiau , Boliang Lou , Steven P. Govek , David J. Thomas
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Sergio G. Duron , Andrew K. Lindstrom , Andrew K. Shiau , Boliang Lou , Steven P. Govek , David J. Thomas
IPC分类号： A61K31/495 , C07K14/705
CPC分类号： C07D209/08 , C07D209/26 , C07D211/96 , C07D213/74 , C07D241/04 , C07D257/04 , C07D295/26 , C07D317/66 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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7.发明申请ARYL-SUBSTITUTED HETEROCYCLIC PDE4 INHIBITORS AS ANTI-INFLAMMATORY AGENTS 审中-公开ARYL取代的杂环化PDE4抑制剂作为抗炎剂公开(公告)号：US20100105729A1
公开(公告)日：2010-04-29
申请号：US12444533
申请日：2007-09-20
IPC分类号： A61K31/4155 , A61K31/4709 , C07D409/04 , C07D401/04 , C07D403/04 , A61P29/00
CPC分类号： A61K31/415 , A61K31/4155 , A61K31/4709
摘要： Disclosed herein are potent and selective aryl-substituted heterocyclic compounds, useful as inhibitors of phosphodiesterase 4 (PDE4), compositions comprising the same, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of PDE4 activity are also provided, as well as methods for the treatment of inflammatory diseases and other diseases in which PDE4 or one of its isoforms may play a role.
摘要翻译： 本文公开了有效和选择性的芳基取代的杂环化合物，其可用作磷酸二酯酶4（PDE4）的抑制剂，包含其的组合物及其作为用于治疗疾病的药物的应用。 还提供了抑制PDE4活性的方法，以及治疗炎性疾病和其中PDE4或其一种同工型可能发挥作用的其它疾病的方法。
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公开(公告)号：US20090275586A1
公开(公告)日：2009-11-05
申请号：US12444539
申请日：2007-09-20
IPC分类号： A61K31/5025 , C07D471/04 , A61P35/00
CPC分类号： A61K31/519 , A61K31/166 , A61K31/4015 , A61K31/4162 , A61K31/4192 , A61K31/428 , A61K31/4365 , A61K31/443 , A61K31/4741 , A61K31/498 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/538
摘要： The present invention is directed to potent and selective heterocyclic compounds, useful as inhibitors of phosphodiesterase 4 (PDE4), compositions comprising the same, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of PDE4 activity are also provided, as well as methods for the treatment of inflammatory diseases and other diseases in which PDE4 or one of its isoforms may play a role.
摘要翻译： 本发明涉及有效和选择性的杂环化合物，其可用作磷酸二酯酶4（PDE4）的抑制剂，包含其的组合物及其作为用于治疗疾病的药物的应用。 还提供了抑制PDE4活性的方法，以及治疗炎性疾病和其中PDE4或其一种同工型可能发挥作用的其它疾病的方法。
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公开(公告)号：US20130116279A1
公开(公告)日：2013-05-09
申请号：US13290632
申请日：2011-11-07
IPC分类号： A61K31/4709 , A61P27/02 , C12N9/99 , A61P29/00 , A61P25/00 , C07D401/12 , A61P27/06
CPC分类号： A61K31/4709 , A61K31/4704 , C07D401/12 , C12N9/16 , C12Y301/04053
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
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公开(公告)号：US08080563B2
公开(公告)日：2011-12-20
申请号：US12307730
申请日：2007-07-06
IPC分类号： A61K31/47 , C07D401/12
CPC分类号： A61K31/4709 , A61K31/4704 , A61K45/06 , C07D401/12 , A61K2300/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PD E4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
摘要翻译： 本发明涉及可用作磷酸二酯酶4（PD E4）抑制剂的化合物和方法，用于治疗或预防炎性疾病和涉及升高的细胞因子和促炎介质的其它疾病。
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