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公开(公告)号：US07834004B2
公开(公告)日：2010-11-16
申请号：US12204489
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
IPC分类号： A61K31/496 , A61K31/343 , A61K31/404 , A61K31/551 , A61K31/495 , C07D333/52 , C07D403/02 , C07D209/04 , C07D405/02 , C07D307/78
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号：US20090264417A1
公开(公告)日：2009-10-22
申请号：US12204489
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
IPC分类号： A61K31/551 , C07D295/26 , A61K31/495 , A61K31/496 , C07K1/107 , C07D401/04 , C07D403/12
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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公开(公告)号：US07494999B2
公开(公告)日：2009-02-24
申请号：US11258463
申请日：2005-10-25
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
IPC分类号： A61K31/4965 , C07D241/04
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号：US20090029971A1
公开(公告)日：2009-01-29
申请号：US12204459
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
IPC分类号： A61K31/496 , C07D241/04 , C07D401/04 , C07D211/70 , A61K31/4418 , A61K31/551 , A61K31/495 , C07D401/12 , C07D409/14
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号：US07915253B2
公开(公告)日：2011-03-29
申请号：US12204459
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen K. Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen K. Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
IPC分类号： A61K31/496 , A61K31/4418 , A61K31/551 , A61K31/495 , C07D241/04 , C07D401/04 , C07D211/70 , C07D401/12 , C07D409/14
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号：US20090227599A1
公开(公告)日：2009-09-10
申请号：US12396513
申请日：2009-03-03
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Sergio G. Duron , Andrew K. Lindstrom , Andrew K. Shiau , Boliang Lou , Steven P. Govek , David J. Thomas
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Sergio G. Duron , Andrew K. Lindstrom , Andrew K. Shiau , Boliang Lou , Steven P. Govek , David J. Thomas
IPC分类号： A61K31/495 , C07K14/705
CPC分类号： C07D209/08 , C07D209/26 , C07D211/96 , C07D213/74 , C07D241/04 , C07D257/04 , C07D295/26 , C07D317/66 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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公开(公告)号：US20060167012A1
公开(公告)日：2006-07-27
申请号：US11258463
申请日：2005-10-25
申请人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Carmen Robinson , Sergio Duron , Michael Sertic , Andrew Lindstrom , Andrew Shiau , Christopher Bayne , Mehmet Kahraman , Boliang Lou , Steven Govek
发明人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Carmen Robinson , Sergio Duron , Michael Sertic , Andrew Lindstrom , Andrew Shiau , Christopher Bayne , Mehmet Kahraman , Boliang Lou , Steven Govek
IPC分类号： A61K31/495 , A61K31/4439 , A61K31/44 , C07D403/02
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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公开(公告)号：US20060205736A1
公开(公告)日：2006-09-14
申请号：US11435082
申请日：2006-05-16
申请人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Sergio Duron , Andrew Lindstrom , Andrew Shiau , Boliang Lou , Steven Govek , David Thomas
发明人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Sergio Duron , Andrew Lindstrom , Andrew Shiau , Boliang Lou , Steven Govek , David Thomas
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D209/08 , C07D209/26 , C07D211/96 , C07D213/74 , C07D241/04 , C07D257/04 , C07D295/26 , C07D317/66 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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9.发明申请Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders 审中-公开p38激酶的新型邻三苯基抑制剂和治疗炎症性疾病的方法公开(公告)号：US20060252807A1
公开(公告)日：2006-11-09
申请号：US11409451
申请日：2006-04-20
申请人： Daniel Severance , Elisabeth Gardiner , Stewart Noble , Boliang Lou , Allen Borchardt , Jeffrey Roppe , Mehmet Kahraman , Dana Siegel , Shawn Scranton
发明人： Daniel Severance , Elisabeth Gardiner , Stewart Noble , Boliang Lou , Allen Borchardt , Jeffrey Roppe , Mehmet Kahraman , Dana Siegel , Shawn Scranton
IPC分类号： C07D417/04 , A61K31/433 , A61K31/426
CPC分类号： C07D413/04 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/426 , A61K31/433 , C07D263/16 , C07D277/56 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04
摘要： The present invention relates to compounds and methods useful as inhibitors of p38 kinase for the treatment or prevention and treatment of diseases such as inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, angiogenic disorders, infectious diseases, neurodegenerative diseases, and viral diseases.
摘要翻译： 本发明涉及可用作p38激酶抑制剂的化合物和方法，用于治疗或预防和治疗疾病如炎症性疾病，自身免疫性疾病，破坏性骨病，增殖性疾病，血管生成性疾病，感染性疾病，神经变性疾病和病毒性疾病 。
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10.发明授权Method for synthesis of &agr;-sulfonamido amide, carboxylic acid and hydroxamic acid derivatives 失效α-亚磺酰氨基酰胺，羧酸和异羟肟酸衍生物的合成方法公开(公告)号：US06583318B2
公开(公告)日：2003-06-24
申请号：US10146713
申请日：2002-05-15
申请人： Eugene Campian , Boliang Lou , Adnan M. M. Mjalli
发明人： Eugene Campian , Boliang Lou , Adnan M. M. Mjalli
IPC分类号： C07C30300
CPC分类号： C07C303/40 , C07C311/19 , C07C311/29
摘要： A method of synthesizing &agr;-sulfonamido amide, carboxylic acid or hydroxamic acid derivatives comprising providing a set of polymer-bound reactant(s) (sulfonamide, aldehyde or ketone, isocyanide or acid) to react with three sets of the other three reactants to form an array of polymer-bound &agr;-sulfonamido amide-type intermediates and use of such intermediates for the preparation of combinatorial libraries.
摘要翻译： 一种合成α-亚磺酰氨基酰胺，羧酸或异羟肟酸衍生物的方法，包括提供一组聚合物结合的反应物（磺酰胺，醛或酮，异氰化物或酸）与三组其他三种反应物反应形成 聚合物结合的α-亚磺酰氨基酰胺型中间体阵列以及这种中间体用于制备组合文库的用途。
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