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1.
公开(公告)号:US07834004B2
公开(公告)日:2010-11-16
申请号:US12204489
申请日:2008-09-04
申请人: Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
发明人: Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
IPC分类号: A61K31/496 , A61K31/343 , A61K31/404 , A61K31/551 , A61K31/495 , C07D333/52 , C07D403/02 , C07D209/04 , C07D405/02 , C07D307/78
CPC分类号: C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译: 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物,包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号:US20090264417A1
公开(公告)日:2009-10-22
申请号:US12204489
申请日:2008-09-04
申请人: Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
发明人: Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
IPC分类号: A61K31/551 , C07D295/26 , A61K31/495 , A61K31/496 , C07K1/107 , C07D401/04 , C07D403/12
CPC分类号: C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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3.
公开(公告)号:US07494999B2
公开(公告)日:2009-02-24
申请号:US11258463
申请日:2005-10-25
申请人: Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
发明人: Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
IPC分类号: A61K31/4965 , C07D241/04
CPC分类号: C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译: 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物,包含其的药物组合物和使用其的治疗疾病的方法。
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4.
公开(公告)号:US20090029971A1
公开(公告)日:2009-01-29
申请号:US12204459
申请日:2008-09-04
申请人: Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
发明人: Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
IPC分类号: A61K31/496 , C07D241/04 , C07D401/04 , C07D211/70 , A61K31/4418 , A61K31/551 , A61K31/495 , C07D401/12 , C07D409/14
CPC分类号: C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译: 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物,包含其的药物组合物和使用其的治疗疾病的方法。
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5.
公开(公告)号:US07915253B2
公开(公告)日:2011-03-29
申请号:US12204459
申请日:2008-09-04
申请人: Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen K. Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
发明人: Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen K. Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
IPC分类号: A61K31/496 , A61K31/4418 , A61K31/551 , A61K31/495 , C07D241/04 , C07D401/04 , C07D211/70 , C07D401/12 , C07D409/14
CPC分类号: C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译: 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物,包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号:US20090227599A1
公开(公告)日:2009-09-10
申请号:US12396513
申请日:2009-03-03
申请人: Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Sergio G. Duron , Andrew K. Lindstrom , Andrew K. Shiau , Boliang Lou , Steven P. Govek , David J. Thomas
发明人: Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Sergio G. Duron , Andrew K. Lindstrom , Andrew K. Shiau , Boliang Lou , Steven P. Govek , David J. Thomas
IPC分类号: A61K31/495 , C07K14/705
CPC分类号: C07D209/08 , C07D209/26 , C07D211/96 , C07D213/74 , C07D241/04 , C07D257/04 , C07D295/26 , C07D317/66 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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公开(公告)号:US20080287477A1
公开(公告)日:2008-11-20
申请号:US12083426
申请日:2006-10-11
IPC分类号: A61K31/192 , C07D239/42 , C07C311/29 , A61P29/00 , A61P17/00 , A61P27/02 , A61P19/00 , A61K31/505 , A61P3/00
CPC分类号: C07C311/17 , C07C311/18 , C07C2602/08 , C07D239/42 , C07D261/20
摘要: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译: 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物,包含其的药物组合物和使用其的治疗疾病的方法。
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8.Sulfonyl-Substituted Aryl Compounds as Modulators of Peroxisome Proliferator Activated Receptors 审中-公开
标题翻译: 磺酰取代的芳基化合物作为过氧化物酶体增殖剂激活受体的调节剂公开(公告)号:US20090143396A1
公开(公告)日:2009-06-04
申请号:US12083430
申请日:2006-10-11
IPC分类号: A61K31/495 , C07D295/26 , A61P3/10
CPC分类号: C07D295/26
摘要: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译: 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物,包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号:US07517884B2
公开(公告)日:2009-04-14
申请号:US11435082
申请日:2006-05-16
IPC分类号: A61K31/4965 , C07D241/04
CPC分类号: C07D209/08 , C07D209/26 , C07D211/96 , C07D213/74 , C07D241/04 , C07D257/04 , C07D295/26 , C07D317/66 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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10.
公开(公告)号:US20080139558A1
公开(公告)日:2008-06-12
申请号:US11678572
申请日:2007-02-23
申请人: Nicholas D. Smith , Jeffrey R. Roppe , Celine Bonnefous , Joseph E. Payne , Hui Zhuang , Xiaohong Chen , Andrew K. Lindstrom , Sergio G. Duron , Christian A. Hassig , Stewart A. Noble
发明人: Nicholas D. Smith , Jeffrey R. Roppe , Celine Bonnefous , Joseph E. Payne , Hui Zhuang , Xiaohong Chen , Andrew K. Lindstrom , Sergio G. Duron , Christian A. Hassig , Stewart A. Noble
IPC分类号: A61K31/47 , A61K31/5377 , A61P11/06 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/14 , A61P29/02 , A61P3/10 , A61P31/00 , A61P31/12 , A61P31/22 , A61P37/00 , A61P37/08 , A61P9/10 , C07D215/227 , C07D295/00 , C07D471/04
CPC分类号: C07D405/12 , A61K31/4704 , A61K31/4709 , C07D215/227 , C07D401/06 , C07D401/12 , C07D409/12
摘要: The present invention relates to novel quinolones of Formula I that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering the compounds for the treatment of disease.
摘要翻译: 本发明涉及抑制诱导型NOS合酶的新型喹诺酮,以及通过给予治疗化合物来合成和使用包括抑制或调节一氧化氮合成和/或降低一氧化氮水平的方法的化合物的方法 的疾病
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