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公开(公告)号：US20100179094A1
公开(公告)日：2010-07-15
申请号：US12625217
申请日：2009-11-24
申请人： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao , Marco Gottardis , Joan Carboni
发明人： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao , Marco Gottardis , Joan Carboni
CPC分类号： C07K14/78 , A61K38/39 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/475 , C07K16/2863 , C07K2317/31 , C07K2317/34 , C07K2317/92 , C07K2318/20 , C07K2319/30
摘要： The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
摘要翻译： 本发明涉及包含EGFR结合结构域和用于诊断，研究和治疗应用的不同IGFIR结合结构域的双特异性分子。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码创新蛋白质的多核苷酸的载体。 示例性双特异性分子包括基于第十纤连蛋白III型结构域的抗体样蛋白二聚体。
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公开(公告)号：US08343501B2
公开(公告)日：2013-01-01
申请号：US12625217
申请日：2009-11-24
申请人： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao , Marco Gottardis , Joan Carboni
发明人： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao , Marco Gottardis , Joan Carboni
IPC分类号： A61K38/17 , A61K38/39 , A61K47/48 , C07K14/71 , C07K14/435
CPC分类号： C07K14/78 , A61K38/39 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/475 , C07K16/2863 , C07K2317/31 , C07K2317/34 , C07K2317/92 , C07K2318/20 , C07K2319/30
摘要： The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
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公开(公告)号：US08221765B2
公开(公告)日：2012-07-17
申请号：US12470989
申请日：2009-05-22
申请人： Ray Camphausen , Eric Furfine , Irvith M. Carvajal , H. Nicholas Marsh , Marco Gottardis , Joan Carboni , Ricardo Attar
发明人： Ray Camphausen , Eric Furfine , Irvith M. Carvajal , H. Nicholas Marsh , Marco Gottardis , Joan Carboni , Ricardo Attar
IPC分类号： A61K38/17 , A61K47/48 , C07K14/71 , C07K14/435
CPC分类号： C07K14/78 , A61K38/39 , A61K39/3955 , A61K47/60 , A61K2039/505 , C07K14/71 , C07K14/715 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/00 , C07K2319/74
摘要： The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明涉及包含通过多肽接头连接的至少两个纤连蛋白支架结构域的多价多肽。 本发明还涉及用于诊断，研究和治疗应用的多价多肽。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US08728483B2
公开(公告)日：2014-05-20
申请号：US13533382
申请日：2012-06-26
申请人： Ray Camphausen , Eric Furfine , Irvith M. Carvajal , H. Nicholas Marsh , Marco Gottardis , Joan Carboni , Ricardo Attar
发明人： Ray Camphausen , Eric Furfine , Irvith M. Carvajal , H. Nicholas Marsh , Marco Gottardis , Joan Carboni , Ricardo Attar
IPC分类号： A61K38/39 , A61K47/48 , C07K14/705 , C07K14/78 , C07K14/435
CPC分类号： C07K14/78 , A61K38/39 , A61K39/3955 , A61K47/60 , A61K2039/505 , C07K14/71 , C07K14/715 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/00 , C07K2319/74
摘要： The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明涉及包含通过多肽接头连接的至少两个纤连蛋白支架结构域的多价多肽。 本发明还涉及用于诊断，研究和治疗应用的多价多肽。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US20130012435A1
公开(公告)日：2013-01-10
申请号：US13533382
申请日：2012-06-26
申请人： Ray Camphausen , Eric Furfine , Irvith M. Carvajal , H. Nicholas Marsh , Marco Gottardis , Joan Carboni , Ricardo Attar
发明人： Ray Camphausen , Eric Furfine , Irvith M. Carvajal , H. Nicholas Marsh , Marco Gottardis , Joan Carboni , Ricardo Attar
CPC分类号： C07K14/78 , A61K38/39 , A61K39/3955 , A61K47/60 , A61K2039/505 , C07K14/71 , C07K14/715 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/00 , C07K2319/74
摘要： The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
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6.发明授权Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR 有权基于用于酪氨酸激酶受体的工程化蛋白质的靶向治疗剂，包括IGF-1R公开(公告)号：US08470332B2
公开(公告)日：2013-06-25
申请号：US12312725
申请日：2007-11-21
IPC分类号： A61K38/17 , A61K38/39 , A61K47/48 , C07K14/71 , C07K14/435
CPC分类号： C07K14/78 , A61K38/18 , A61K47/60 , A61K47/643 , A61K47/644 , A61K47/68 , C07K14/00 , C07K14/765 , C07K14/79 , C07K16/00 , C07K2319/74 , C12N15/1062 , C40B30/04 , C40B40/08 , C40B40/10
摘要： The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明提供了与胰岛素样生长因子-I受体（IGF-1R）以及其它重要蛋白质结合的创新蛋白质。 本发明还提供药物制剂中的创新蛋白质和这种蛋白质的衍生物及其在诊断，研究和治疗应用中的用途。 本发明还提供包含这些蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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7.发明申请TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS FOR TYROSINE KINASES RECEPTORS, INCLUDING IGF-IR 有权基于酪氨酸激酶受体的工程化蛋白质的针对性治疗剂，包括IGF-IR公开(公告)号：US20100121033A1
公开(公告)日：2010-05-13
申请号：US12312725
申请日：2007-11-21
IPC分类号： C07K14/765 , C07K14/00 , C07K16/00 , C07K14/79
CPC分类号： C07K14/78 , A61K38/18 , A61K47/60 , A61K47/643 , A61K47/644 , A61K47/68 , C07K14/00 , C07K14/765 , C07K14/79 , C07K16/00 , C07K2319/74 , C12N15/1062 , C40B30/04 , C40B40/08 , C40B40/10
摘要： The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明提供了与胰岛素样生长因子-I受体（IGF-1R）以及其它重要蛋白质结合的创新蛋白质。 本发明还提供药物制剂中的创新蛋白质和这种蛋白质的衍生物及其在诊断，研究和治疗应用中的用途。 本发明还提供包含这些蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US08524244B2
公开(公告)日：2013-09-03
申请号：US12867406
申请日：2009-02-10
申请人： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
发明人： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
IPC分类号： A61K38/17 , A61K38/39 , A61K47/48 , C07K14/71 , C07K14/435
CPC分类号： C07K14/78 , A61K38/00 , C07K14/765 , C07K14/79 , C07K16/2863 , C07K19/00 , C07K2317/31 , C07K2318/20 , C07K2319/30
摘要： The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明涉及结合表皮生长因子受体（EGFR）的单结构域蛋白。 本发明还涉及用于诊断，研究和治疗应用的单结构域蛋白。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US20110053842A1
公开(公告)日：2011-03-03
申请号：US12867406
申请日：2009-02-10
申请人： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
发明人： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
CPC分类号： C07K14/78 , A61K38/00 , C07K14/765 , C07K14/79 , C07K16/2863 , C07K19/00 , C07K2317/31 , C07K2318/20 , C07K2319/30
摘要： The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明涉及结合表皮生长因子受体（EGFR）的单结构域蛋白。 本发明还涉及用于诊断，研究和治疗应用的单结构域蛋白。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US09562089B2
公开(公告)日：2017-02-07
申请号：US13699458
申请日：2011-05-26
申请人： Ray Camphausen , John O'Loughlin , Bernice Yeung , Yihong Zhang
发明人： Ray Camphausen , John O'Loughlin , Bernice Yeung , Yihong Zhang
IPC分类号： C07K14/705 , C07K14/78 , C07K14/435 , C07K16/46 , A61K38/39 , A61K38/17 , A61K38/18 , C07K14/71 , C07K14/715 , C07K16/28
CPC分类号： C07K14/78 , A61K38/00 , C07K14/71 , C07K14/7155 , C07K16/2863 , C07K2317/31 , C07K2317/34 , C07K2317/94 , C07K2318/20 , C07K2319/00 , C07K2319/30
摘要： The present application provides fibronectin based scaffold proteins associated with improved stability. The application also relates to stable formulations of fibronectin based scaffold proteins and the use thereof in diagnostic, research and therapeutic applications. The application further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising such polynucleotides.
摘要翻译： 本申请提供与改善的稳定性相关的基于纤连蛋白的支架蛋白。 该应用还涉及基于纤维连接蛋白的支架蛋白的稳定制剂及其在诊断，研究和治疗应用中的用途。 本申请还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含这种多核苷酸的载体。
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