公开(公告)号：US20050048532A1

公开(公告)日：2005-03-03

申请号：US10809814

申请日：2004-03-26

申请人： Suman Preet Khanuja ,  Suchi Srivastava ,  Ajit Shasany ,  Tiruppadiripuliyur Ranganathan Kumar ,  Mahendra Darokar ,  Preeti Chand ,  Sushil Kumar

发明人： Suman Preet Khanuja ,  Suchi Srivastava ,  Ajit Shasany ,  Tiruppadiripuliyur Ranganathan Kumar ,  Mahendra Darokar ,  Preeti Chand ,  Sushil Kumar

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C07K14/245

CPC分类号： C12Q1/689 ,  C07H21/04 ,  C12Q2600/156

摘要： The present invention relates to an alpha-arteether resistance domain (ADR) of Sequence ID No.1 and a method of identifying ADR in alpha-arteether resistant pathogens and lastly, it relates to set three pairs of primers of sequence ID Nos. 3 to 8.

摘要翻译： 本发明涉及序列号为1的α-萜烯抗性结构域（ADR）和鉴定α-萜烯抗性病原体中的ADR的方法，最后涉及序列号3〜 8。

公开(公告)号：US07510836B2

公开(公告)日：2009-03-31

申请号：US10809814

申请日：2004-03-26

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasany ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Mahendra Pandurang Darokar ,  Preeti Chand ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasany ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Mahendra Pandurang Darokar ,  Preeti Chand ,  Sushil Kumar

IPC分类号： C12Q1/68

CPC分类号： C12Q1/689 ,  C07H21/04 ,  C12Q2600/156

摘要： The present invention relates to an alpha-arteether resistance domain (ADR) of Sequence ID No.1 and a method of identifying ADR in alpha-arteether resistant pathogens and lastly, it relates to set three pairs of primers of sequence ID Nos. 3 to 8.

摘要翻译： 本发明涉及序列号为1的α-萜烯抗性结构域（ADR）和鉴定α-萜烯抗性病原体中的ADR的方法，最后涉及序列号3〜 8。

公开(公告)号：US06514541B2

公开(公告)日：2003-02-04

申请号：US09536124

申请日：2000-03-28

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasney ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Krishna Kumar Agarwal ,  Ateeque Ahmed ,  Nirmal Kumar Patra ,  Prachi Sinha ,  Sunita Dhawan ,  Dharmendra Saikia ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasney ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Krishna Kumar Agarwal ,  Ateeque Ahmed ,  Nirmal Kumar Patra ,  Prachi Sinha ,  Sunita Dhawan ,  Dharmendra Saikia ,  Sushil Kumar

IPC分类号： A61K3578

CPC分类号： A61K36/23 ,  A61K36/534 ,  Y10S514/924 ,  A61K2300/00

摘要： A formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of thymol obtained from the plant Trachyspermum ammi, mint oil containing an appropriate amount of monoterpenes obtained from a hybrid of Mentha spicata and Mentha arvensis, and conventional additives. A method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistance in a patient by administration of a therapeutically effective amount of the formulation.

摘要翻译： 一种可用于治疗耐药性细菌感染的制剂，其包含从植物Trachyspermum ammi获得的有效量的百里酚，含有从Mentha spicata和Mentha arvensis的杂种获得的适量的单萜和常规添加剂的薄荷油。 通过施用治疗有效量的制剂，通过混合上述成分和用于治疗患者耐药性的方法来制备制剂的方法。

公开(公告)号：US20050251887P1

公开(公告)日：2005-11-10

申请号：US10838531

申请日：2004-05-04

申请人： Sushil Kumar ,  Shashi Rai ,  Sanjay Kumar ,  Digvijay Singh ,  Suchi Srivastava ,  Raghvendra Mishra

发明人： Sushil Kumar ,  Shashi Rai ,  Sanjay Kumar ,  Digvijay Singh ,  Suchi Srivastava ,  Raghvendra Mishra

IPC分类号： A01H5/00 ,  A01H5/02

CPC分类号： A01H5/02 ,  Y02A40/135

摘要： The present invention relates to the development of a unique inflorescence bearing mutant plant type lli/lli (LEAF-LESS INFLORESCENCE). Further the present invention relates to the development of a unique inflorescence bearing mutant plant type lli/lli (LEAF-LESS INFLORESCENCE) through chemical mutagenesis The present invention relates to the development of a new and distinct plant type for floricultural usage. The new type is a monogenic Mendelian recessive stable mutant plant of Catharanthus roseus with a novel leafless inflorescence architecture with increased flower frequency. This distinct plant of Catharanthus roseus was developed through chemical mutagenesis followed by salt tolerance selection.

摘要翻译： 本发明涉及开发具有独特花序的突变体植物型lli / lli（LEAF-LESS INFLORESCENCE）。 此外，本发明涉及通过化学诱变开发具有独特花序的突变植物型lli / lli（LEAF-LESS INFLORESCENCE）。本发明涉及开发用于花卉栽培用途的新的和不同的植物类型。 新型是长春花的单基因孟德尔隐性稳定突变植物，具有增加花频率的新颖无叶花序结构。 通过化学诱变，然后耐盐选择，开发了长春花的不同植物。

公开(公告)号：USPP18315P3

公开(公告)日：2007-12-18

申请号：US10838531

申请日：2004-05-04

申请人： Sushil Kumar ,  Shashi Pandey Rai ,  Sanjay Rai Kumar ,  Digvijay Singh ,  Suchi Srivastava ,  Raghvendra Kumar Mishra

发明人： Sushil Kumar ,  Shashi Pandey Rai ,  Sanjay Rai Kumar ,  Digvijay Singh ,  Suchi Srivastava ,  Raghvendra Kumar Mishra

IPC分类号： A01H5/00

CPC分类号： A01H5/02 ,  Y02A40/135

摘要： The present invention relates to the development of a unique inflorescence bearing mutant plant type lli/lli (LEAF-LESS INFLORESCENCE). Further the present invention relates to the development of a unique inflorescence bearing mutant plant type lli/lli (LEAF-LESS INFLORESCENCE) through chemical mutagenesis. The present invention relates to the development of a new and distinct plant type for floricultural usage. The new type is a monogenic Mendelian recessive stable mutant plant of Catharanthus roseus with a novel leafless inflorescence architecture with increased flower frequency. This distinct plant of Catharanthus roseus was developed through chemical mutagenesis followed by salt tolerance selection.

摘要翻译： 本发明涉及开发具有独特花序的突变体植物型lli / lli（LEAF-LESS INFLORESCENCE）。 此外，本发明涉及通过化学诱变开发具有独特花序的突变植物型lli / lli（LEAF-LESS INFLORESCENCE）。 本发明涉及开发用于花卉栽培用途的新型和不同植物类型。 新型是长春花的单基因孟德尔隐性稳定突变植物，具有增加花频率的新颖无叶花序结构。 通过化学诱变，然后耐盐选择，开发了长春花的不同植物。

公开(公告)号：US06824795B2

公开(公告)日：2004-11-30

申请号：US10322731

申请日：2002-12-19

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasney ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Krishna Kumar Agarwal ,  Ateeque Ahmed ,  Nirmal Kumar Patra ,  Prachi Sinha ,  Sunita Dhawan ,  Dharmendra Saikia ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasney ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Krishna Kumar Agarwal ,  Ateeque Ahmed ,  Nirmal Kumar Patra ,  Prachi Sinha ,  Sunita Dhawan ,  Dharmendra Saikia ,  Sushil Kumar

IPC分类号： A61K3578

CPC分类号： A61K36/23 ,  A61K36/534 ,  A61K2300/00

摘要： A formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of thymol obtained from the plant Trachyspermum ammi, mint oil containing an appropriate amount of monoterpenes obtained from a hybrid of Mentha spicata and Mentha arvensis, and conventional additives. A method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistance in a patient by administration of a therapeutically effective amount of the formulation.

摘要翻译： 一种可用于治疗耐药性细菌感染的制剂，其包含从植物Trachyspermum ammi获得的有效量的百里酚，含有从Mentha spicata和Mentha arvensis的杂种获得的适量的单萜和常规添加剂的薄荷油。 通过施用治疗有效量的制剂，通过混合上述成分和用于治疗患者耐药性的方法来制备制剂的方法。

公开(公告)号：US6127405A

公开(公告)日：2000-10-03

申请号：US179204

申请日：1998-10-27

申请人： Sushil Kumar ,  Suman Preet Singh Khanuja ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Dharam Chand Jain ,  Suchi Srivastava ,  Asish Kumar Bhattacharya ,  Dharmendra Saikia ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Ram Prakash Sharma

发明人： Sushil Kumar ,  Suman Preet Singh Khanuja ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Dharam Chand Jain ,  Suchi Srivastava ,  Asish Kumar Bhattacharya ,  Dharmendra Saikia ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Ram Prakash Sharma

IPC分类号： A61K31/352 ,  A61K31/335

CPC分类号： A61K31/352

摘要： The present invention relates to use .alpha.-arteether as a antibacterial agent, preferably for gyr mutant bacteria which are resistant to quinolone drugs and can be used as therapeutic agents for treating drug resistant bacterial infections, and also as a antifungal agent.

摘要翻译： 本发明涉及使用α-arteether作为抗菌剂，优选用于对喹诺酮药物具有抗性的gyr突变体细菌，并且可用作治疗药物抗性细菌感染的治疗剂，并且还可用作抗真菌剂。

公开(公告)号：US06676974B2

公开(公告)日：2004-01-13

申请号：US10105794

申请日：2002-03-26

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Madan Mohan Gupta ,  Arvind Kumar Tripathy ,  Monika Singh ,  Janak Raj Bahl ,  Raj Kishori Lal ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Madan Mohan Gupta ,  Arvind Kumar Tripathy ,  Monika Singh ,  Janak Raj Bahl ,  Raj Kishori Lal ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Sushil Kumar

IPC分类号： A01N5906

CPC分类号： A61K36/899 ,  Y02A50/473

摘要： The present invention relates a hexane bioactive fraction and obtained from the roots of an aromatic plant named Vetiveria zizanioides commonly found in India for inhibiting the growth of drug resistant bacterial infections in humans and animals; also relates to a pharmaceutical composition comprising the bioactive extract with other additives for inhibiting the growth of drug resistant bacterial infections in humans and animals and a process for the isolation of said bioactive extract

摘要翻译： 本发明涉及己烷生物活性级分，其获自在印度通常发现的名为Vetiveria zizanioides的芳香植物的根，用于抑制人和动物中耐药细菌感染的生长; 还涉及一种药物组合物，其包含生物活性提取物与用于抑制人和动物中耐药细菌感染生长的其它添加剂和分离所述生物活性提取物的方法

公开(公告)号：US06423741B1

公开(公告)日：2002-07-23

申请号：US09538439

申请日：2000-03-29

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Ajit Kumar Shasany ,  Dharam Chand Jain ,  Mahendra Pandurang Darokar ,  Dharmendra Saikia ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Ajit Kumar Shasany ,  Dharam Chand Jain ,  Mahendra Pandurang Darokar ,  Dharmendra Saikia ,  Sushil Kumar

IPC分类号： A61K31335

CPC分类号： A61K31/352

摘要： This invention is related to the development of strategic and novel composition comprising &agr; arteether and nalidixic acid or quinolone drugs, said composition useful as an advanced generation drug to counter the resistance development itself and having a potential to be used in treating infectious diseases and in inhibiting the resistance developed due to mutation in the gyr A gene of bacteria, particularly in those cases where drug resistant strains are known to appear very frequently.

摘要翻译： 本发明涉及包含α-萜烯和萘啶酸或喹诺酮类药物的战略和新型组合物的发展，所述组合物可用作抗逆转发展本身并具有用于治疗感染性疾病和抑制作用的潜力 由于细菌的gyr A基因突变而产生的抗性，特别是在已知耐药菌株出现频繁的情况下。

公开(公告)号：US06833249B2

公开(公告)日：2004-12-21

申请号：US10102939

申请日：2002-03-22

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Ajit Kumar Shasany

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Ajit Kumar Shasany

IPC分类号： C12Q118

CPC分类号： C12Q1/18 ,  Y10S435/975

摘要： The present invention relates to a rapid, sensitive, simple, and cost-effective spectrophotometric method of detecting and quantifying mycolic acid in a mycolic acid-fuschin dye complex with absorbance maxima ranging between 490-500 nm in the presence of various test compounds, for screening mycolic acid biosynthesis inhibitors useful as anti-microbial agents and a diagnostic kit thereof comprising basic fuschin dye in the concentration ranging between 0.1-1.0 gm/100 ml, phenol and 95% ethanol in the ratio ranging between 1:4 to 2:1 (v/v), and phenol and distilled water in the ratio ranging between 1:14 to 1:25.

摘要翻译： 本发明涉及快速，灵敏，简单且成本有效的分光光度法，用于在各种试验化合物的存在下，在490-500nm范围内检测和定量霉菌酸 - 富梳素染料络合物中的霉菌酸，用于 筛选可用作抗微生物剂的霉菌酸生物合成抑制剂及其诊断试剂盒，其包含浓度范围为0.1-1.0gm / 100ml的基本fuschin染料，苯酚和95％乙醇之间的比例为1:4至2:1 （v / v），苯酚和蒸馏水的比例范围为1:14至1:25。