公开(公告)号：US07291349B2

公开(公告)日：2007-11-06

申请号：US10761804

申请日：2004-01-21

申请人： Suman Preet Singh Khanuja ,  Pushplata Chaturvedi ,  Anil Kumar Singh ,  Ajit Kumar Shasany ,  Vinay Kumar Agarwal ,  Vivek Kumar Gupta ,  Subhash Chandra Gupta ,  Arun Kumar Tripathy ,  Anirban Pal ,  Dharmendra Saikia ,  Mahendra Pandurang Darokar ,  Krishna Kumar Aggarwal ,  Ravi Prakash Bansal

发明人： Suman Preet Singh Khanuja ,  Pushplata Chaturvedi ,  Anil Kumar Singh ,  Ajit Kumar Shasany ,  Vinay Kumar Agarwal ,  Vivek Kumar Gupta ,  Subhash Chandra Gupta ,  Arun Kumar Tripathy ,  Anirban Pal ,  Dharmendra Saikia ,  Mahendra Pandurang Darokar ,  Krishna Kumar Aggarwal ,  Ravi Prakash Bansal

IPC分类号： A01N65/00

CPC分类号： A61K36/54 ,  A61K36/534 ,  A61K36/8962 ,  A61K2300/00

摘要： The present invention provides an improved preparation based on the synergistic action of garlic extract and essential oil of M. spicata var. Ganga or cinnamon oil against dermatophytic fungus. More particularly, the present invention relates to the synergistic enhancement of activity of a combination by menthyl acetate or Geraniol. The invention also provides a method of preparation of the synergistic combination and the shelf life observed to be more than one year. The cream based preparation is a potent anti-dermatophytic as described and illustrated by in vitro and in vivo evaluations.

摘要翻译： 本发明提供了一种改进的制剂，其基于大蒜提取物和M.spicata var。的精油的协同作用。 甘草或肉桂油抗皮肤真菌。 更具体地，本发明涉及通过乙酸薄荷酯或香叶醇组合的协同增强活性。 本发明还提供了一种制备协同组合的方法和观察到的一年以上的保质期。 基于乳膏的制剂是有效的抗皮肤真菌病，如通过体外和体内评价所描述和说明的。

公开(公告)号：US06858588B2

公开(公告)日：2005-02-22

申请号：US10403814

申请日：2003-03-31

申请人： Suman Preet Singh Khanuja ,  Jai Shanker Arya ,  Ranganathan Santha Kumar Tiruppadiripuliyur ,  Dharmendra Saikia ,  Harpreet Kaur ,  Monika Singh ,  Subhash Chandra Gupta ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Santosh Kumar Srivastava ,  Madan Mohan Gupta ,  Subash Chandra Verma ,  Anirban Pal

发明人： Suman Preet Singh Khanuja ,  Jai Shanker Arya ,  Ranganathan Santha Kumar Tiruppadiripuliyur ,  Dharmendra Saikia ,  Harpreet Kaur ,  Monika Singh ,  Subhash Chandra Gupta ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Santosh Kumar Srivastava ,  Madan Mohan Gupta ,  Subash Chandra Verma ,  Anirban Pal

IPC分类号： A61K31/704 ,  A61K45/06 ,  C07H15/06 ,  A61K31/70 ,  A61K31/7028 ,  C07C255/32 ,  C07H15/00

CPC分类号： C07H15/06 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (−) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.

摘要翻译： 本发明涉及名为NIAZIRIDIN的式I的新型腈糖苷及其类似物及其衍生物。 本发明还涉及一种通过生物活性指导的分离来自pod the的荚果分离下述式I的新型腈糖苷的方法，其命名为NIAZIRIDIN及其衍生物和类似物。 本发明特别涉及下述命名为NIAZIRIDIN及其衍生物和类似物的式I的新型腈糖苷增强常用抗生素如利福平，四环素和氨苄青霉素对革兰氏阳性（+）和（ - ）细菌的生物活性的生物增强活性。 生物分子还通过胃肠膜增强药物，维生素和营养素的吸收，增加其生物利用度。 因此，尼日吉林可以与药物和营养物联合使用，导致药物相关毒性降低，降低成本和化疗持续时间。

公开(公告)号：US07235262B2

公开(公告)日：2007-06-26

申请号：US10822790

申请日：2004-04-13

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K35/22

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06896907B2

公开(公告)日：2005-05-24

申请号：US10135763

申请日：2002-05-01

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K35/22 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  A61K35/24 ,  A61K35/23

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06410059B1

公开(公告)日：2002-06-25

申请号：US09726307

申请日：2000-12-01

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K3522

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： A pharmaceutical composition comprising an antibiotic and cow urine distillate in an amount effective to enhance antimicrobial effect of the antibiotic is disclosed. The antibiotic can be an antifungal agent. The antibiotic can be a quinolone or a fluoroquinolone. The antifungal agent can be azoles, clotrimazole, mystatin or amphotericin.

摘要翻译： 公开了一种药物组合物，其包含抗生素和牛尿液馏出物，其量有效提高抗生素的抗微生物作用。 抗生素可以是抗真菌剂。 抗生素可以是喹诺酮或氟喹诺酮类。 抗真菌剂可以是唑类，克霉唑，丝裂霉素或两性霉素。