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公开(公告)号：US08247382B2
公开(公告)日：2012-08-21
申请号：US12616908
申请日：2009-11-12
申请人： Sumiko Denda , Mitsuhiro Denda , Kazuyuki Ikeyama
发明人： Sumiko Denda , Mitsuhiro Denda , Kazuyuki Ikeyama
CPC分类号： A61K31/23 , A61K31/7072 , A61K31/7076
摘要： A method for increasing oxytocin release through direct action on the epidermal keratinocytes is provided. The method for increasing oxytocin release in the epidermis includes increasing the calcium ion concentration in the epidermal cells. In the method of the present invention, the increase of the calcium ion concentration in the epidermal cells may be achieved by physically stimulating the skin. The physical stimulation may be achieved by applying a heat stimulus and/or a massage. The increase of the calcium ion concentration in the epidermal cells may be achieved by stimulating the epidermal cells by at least one agent selected from the group consisting of ATP, UTP, 4 alpha-phorbol 12,13-didecanoate, and pharmaceutically acceptable salts thereof.
摘要翻译： 提供了通过对表皮角质形成细胞的直接作用增加催产素释放的方法。 增加表皮中催产素释放的方法包括增加表皮细胞中的钙离子浓度。 在本发明的方法中，表皮细胞中钙离子浓度的增加可以通过物理刺激皮肤来实现。 物理刺激可以通过施加热刺激和/或按摩来实现。 表皮细胞中钙离子浓度的增加可以通过至少一种选自ATP，UTP，4α-佛波醇12,13-十一酸酯的药剂及其药学上可接受的盐来刺激表皮细胞来实现。
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公开(公告)号：US20100130438A1
公开(公告)日：2010-05-27
申请号：US12616908
申请日：2009-11-12
申请人： Sumiko Denda , Mitsuhiro Denda , Kazuyuki Ikeyama
发明人： Sumiko Denda , Mitsuhiro Denda , Kazuyuki Ikeyama
IPC分类号： A61K31/7076 , A61K31/7072 , A61K31/23 , C07H19/20 , C07C69/33 , A61P43/00
CPC分类号： A61K31/23 , A61K31/7072 , A61K31/7076
摘要： A method for increasing oxytocin release through direct action on the epidermal keratinocytes is provided. The method for increasing oxytocin release in the epidermis includes increasing the calcium ion concentration in the epidermal cells. In the method of the present invention, the increase of the calcium ion concentration in the epidermal cells may be achieved by physically stimulating the skin. The physical stimulation may be achieved by applying a heat stimulus and/or a massage. The increase of the calcium ion concentration in the epidermal cells may be achieved by stimulating the epidermal cells by at least one agent selected from the group consisting of ATP, UTP, 4 alpha-phorbol 12,13-didecanoate, and pharmaceutically acceptable salts thereof.
摘要翻译： 提供了通过对表皮角质形成细胞的直接作用增加催产素释放的方法。 增加表皮中催产素释放的方法包括增加表皮细胞中的钙离子浓度。 在本发明的方法中，表皮细胞中钙离子浓度的增加可以通过物理刺激皮肤来实现。 物理刺激可以通过施加热刺激和/或按摩来实现。 表皮细胞中钙离子浓度的增加可以通过至少一种选自ATP，UTP，4α-佛波醇12,13-十一酸酯的药剂及其药学上可接受的盐来刺激表皮细胞来实现。
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公开(公告)号：US20070232595A1
公开(公告)日：2007-10-04
申请号：US11727436
申请日：2007-03-27
IPC分类号： A61K31/542 , A61K31/5383 , A61K31/498
CPC分类号： A61K31/498 , A61K31/5383 , A61K31/542
摘要： A method for accelerating cutaneous barrier recovery and a method for preventing epidermal hyperplasia by inhibiting production of Nitric Oxide by an epidermal cell are provided.
摘要翻译： 提供加速皮肤屏障恢复的方法和通过抑制表皮细胞产生一氧化氮来预防表皮增生的方法。
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公开(公告)号：US08894593B2
公开(公告)日：2014-11-25
申请号：US13517188
申请日：2010-12-15
申请人： Kazuyuki Ikeyama , Mieko Nasu , Hiroshi Fukui , Takuya Saiwaki
发明人： Kazuyuki Ikeyama , Mieko Nasu , Hiroshi Fukui , Takuya Saiwaki
CPC分类号： A61H23/0263 , A61H7/007 , A61H2015/0071 , A61H2023/0272 , A61H2201/1604 , A61H2201/165 , A61H2201/1661 , A61H2201/1692 , A61H2205/022 , A61H2230/00
摘要： A massaging device includes a base part, vibrators configured to be brought into contact with target parts of a user and to massage the target parts with vibration, and springs each including a first end fixed to the base part and a second end attached to the corresponding one of the vibrators. The spring constants of the springs are set based on skin stress of the target parts.
摘要翻译： 一种按摩装置，包括基部，构造成与使用者的目标部位接触并且振动地按压目标部位的振动器，以及各自包括固定到基部的第一端和附接到相应的第二端的弹簧 其中一个振动器。 基于目标部件的皮肤应力来设定弹簧的弹簧常数。
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公开(公告)号：US20120253243A1
公开(公告)日：2012-10-04
申请号：US13517188
申请日：2010-12-15
申请人： Kazuyuki Ikeyama , Mieko Nasu , Hiroshi Fukui , Takuya Saiwaki
发明人： Kazuyuki Ikeyama , Mieko Nasu , Hiroshi Fukui , Takuya Saiwaki
IPC分类号： A61H1/00
CPC分类号： A61H23/0263 , A61H7/007 , A61H2015/0071 , A61H2023/0272 , A61H2201/1604 , A61H2201/165 , A61H2201/1661 , A61H2201/1692 , A61H2205/022 , A61H2230/00
摘要： A massaging device includes a base part, vibrators configured to be brought into contact with target parts of a user and to massage the target parts with vibration, and springs each including a first end fixed to the base part and a second end attached to the corresponding one of the vibrators. The spring constants of the springs are set based on skin stress of the target parts.
摘要翻译： 一种按摩装置，包括基部，构造成与使用者的目标部位接触并且振动地按压目标部位的振动器，以及各自包括固定到基部的第一端和附接到相应的第二端的弹簧 其中一个振动器。 基于目标部件的皮肤应力来设定弹簧的弹簧常数。
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