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    Method of making PNA oligomers
    4.
    发明申请
    Method of making PNA oligomers 有权
    制备PNA低聚物的方法

    公开(公告)号：US20060003374A1

    公开(公告)日：2006-01-05

    申请号：US11182936

    申请日：2005-07-15

    申请人： Sung Kim ,  Hyunil Lee ,  Jong Lim ,  Hoon Choi ,  Jae Jeon ,  Sang Ahn ,  Sung Lee ,  Won Yoon

    发明人： Sung Kim ,  Hyunil Lee ,  Jong Lim ,  Hoon Choi ,  Jae Jeon ,  Sang Ahn ,  Sung Lee ,  Won Yoon

    IPC分类号： C12Q1/68 ,  C07D473/02 ,  C07D473/14 ,  C07D43/14

    CPC分类号： C07D417/04 ,  C07B2200/11 ,  C07D277/80 ,  C07D417/12 ,  C07D417/14 ,  Y02P20/55

    摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

    摘要翻译： 本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为氮或C-R' ; J为硫或氧; R'，R 1，R 2，R 3，R 4独立地是H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，R 5是H或被保护或未被保护的天然或非天然α- 氨基酸; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

    PNA monomer and precursor
    6.
    发明申请
    PNA monomer and precursor 有权
    PNA单体和前体

    公开(公告)号：US20050250786A1

    公开(公告)日：2005-11-10

    申请号：US11183025

    申请日：2005-07-15

    申请人： Sung Kim ,  Hyunil Lee ,  Jong Lim ,  Hoon Choi ,  Jae Jeon ,  Sahn Ahn ,  Sung Lee ,  Won Yoon

    发明人： Sung Kim ,  Hyunil Lee ,  Jong Lim ,  Hoon Choi ,  Jae Jeon ,  Sahn Ahn ,  Sung Lee ,  Won Yoon

    IPC分类号： C12N15/09 ,  A61K31/513 ,  A61K31/52 ,  C07D277/80 ,  C07D405/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D473/02 ,  C07D473/18 ,  C07D473/32 ,  C07D473/34 ,  C07D43/14

    CPC分类号： C07D417/04 ,  C07B2200/11 ,  C07D277/80 ,  C07D417/12 ,  C07D417/14 ,  Y02P20/55

    摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrite, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

    摘要翻译： 本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为氮或C-R' ; J为硫或氧; R'，R 1，R 2，R 3，R 4独立地为H，卤素，烷基，硝基，亚硝酸根，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，R 5为H或保护或未保护的天然或非天然α- 氨基酸; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

    PNA monomer and precursor
    7.
    发明申请
    PNA monomer and precursor 有权
    PNA单体和前体

    公开(公告)号：US20050026930A1

    公开(公告)日：2005-02-03

    申请号：US10819769

    申请日：2004-04-06

    申请人： Sung Kim ,  Hyunil Lee ,  Jong Lim ,  Sung Lee

    发明人： Sung Kim ,  Hyunil Lee ,  Jong Lim ,  Sung Lee

    IPC分类号： A61K31/496 ,  C07D263/46 ,  C07D271/10 ,  C07D271/113 ,  C07D413/12 ,  C07D417/02 ,  C07D417/12

    CPC分类号： C07D271/113 ,  C07D263/46 ,  C07D413/12 ,  C07D417/12 ,  Y02P20/55

    摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is sulfur or oxygen; J is nitrogen or C—R′; R1, R′ is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy or a functional group having one of following general formulae: wherein A1, A2, A3, A4, A5, is independently selected from H, halogen such as F, Cl, Br or I, CF3, alkyl, preferably C1-C4 alkyl, nitro, nitrile, alkoxy, preferably C1-C4 alkoxy, halogenated (such as F, Cl, Br and I) alkyl, preferably halogenated C1-C4 alkyl, halogenated (such as F, Cl, Br and I) alkoxy, preferably halogenated C1-C4 alkoxy, phenyl, and halogenated (such as F, Cl, Br and I phenyl; R2 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

    摘要翻译： 本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为硫或氧; J为氮或C-R'; R1，R'独立地为H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基或具有以下通式之一的官能团：其中A1，A2，A3，A4，A5独立地选自H ，卤素如F，Cl，Br或I，CF 3，烷基，优选C 1 -C 4烷基，硝基，腈，烷氧基，优选C 1 -C 4烷氧基，卤代（如F，Cl，Br和I）烷基， C 1 -C 4烷基，卤代（如F，Cl，Br和I）烷氧基，优选卤代C 1 -C 4烷氧基，苯基和卤代（如F，Cl，Br和I苯基; R2是H或被保护或未被保护的一侧 天然或非天然α-氨基酸的链; B是天然或非天然核碱基，其中当所述核碱基具有外来氨基功能时，所述功能受到对酸不稳定的保护基保护，但在弱碱性至中等碱基中稳定 存在硫醇。

    Method for separately executing software, apparatus, and computer-readable recording medium
    9.
    发明授权
    Method for separately executing software, apparatus, and computer-readable recording medium 有权
    用于分别执行软件，装置和计算机可读记录介质的方法

    公开(公告)号：US09454456B2

    公开(公告)日：2016-09-27

    申请号：US13142601

    申请日：2009-12-21

    申请人： Oin Kwon ,  Giseon Nam ,  Minseok Kim ,  Sung Kim

    发明人： Oin Kwon ,  Giseon Nam ,  Minseok Kim ,  Sung Kim

    IPC分类号： G06F9/44 ,  G06F11/36 ,  G06F21/12 ,  G06F11/34

    CPC分类号： G06F11/3604 ,  G06F11/3466 ,  G06F11/3476 ,  G06F11/3612 ,  G06F21/121 ,  G06F21/123

    摘要： The present disclosure provides method, system, and computer readable medium for shared execution of software. The present disclosure relates to method, system, and computer readable recording medium for shared execution of software involving identifying the main modules of a specific software by analyzing its control flow, data flow, and modular structure through a static binary analysis and a runtime profiling, i.e. dynamic analysis, separating the modules from the main software body to store them in a secure environment of a smart card, and storing the main body in a user terminal with the identified modules removed and replaced by an interface code, whereby a co-processing the software at the user's end by the smart card in engagement with the user terminal exclusively enables an execution of the software.

    摘要翻译： 本公开提供了用于共享软件的执行的方法，系统和计算机可读介质。 本公开涉及用于共享软件的方法，系统和计算机可读记录介质，其涉及通过静态二进制分析和运行时分析来分析其控制流，数据流和模块化结构来识别特定软件的主模块， 即动态分析，将模块与主软件体分离，将其存储在智能卡的安全环境中，并将主体存储在用户终端中，并将所识别的模块移除并由接口代码替换，从而进行协同处理 智能卡与用户终端的用户端的软件专门用于执行软件。