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1.发明申请INSULINOTROPIC PEPTIDE DERIVATIVE WHEREIN ITS N-TERMINAL AMINO ACID IS MODIFIED 有权胰岛素衍生物其N-末端氨基酸被修饰公开(公告)号：US20100204451A1
公开(公告)日：2010-08-12
申请号：US12669372
申请日：2008-07-16
申请人： Sung Youb Jung , Chang Ki Lim , Dae Hae Song , Sung Min Bae , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee
发明人： Sung Youb Jung , Chang Ki Lim , Dae Hae Song , Sung Min Bae , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee
IPC分类号： C07K14/00
CPC分类号： C07K14/46 , A61K38/26 , C07K14/57563 , C07K14/605
摘要： The present invention relates to an N-terminal amino acid-modified insulinotropic peptide having a high activity, and to a pharmaceutical composition comprising the same. The insulinotropic peptide derivatives according to the present invention exhibit therapeutic effects, which are not observed in native and other insulinotropic peptide analogs. Therefore, the insulinotropic peptide derivatives and the pharmaceutical composition comprising the same according to the present invention can be effectively provided for the treatment of the diseases.
摘要翻译： 本发明涉及具有高活性的N-末端氨基酸修饰的促胰岛素肽以及包含其的药物组合物。 根据本发明的促胰岛素肽衍生物显示出在天然和其他促胰岛素肽类似物中未观察到的治疗效果。 因此，可以有效地提供促胰岛素肽衍生物和包含其的本发明的药物组合物用于治疗疾病。
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公开(公告)号：US09422349B2
公开(公告)日：2016-08-23
申请号：US12669372
申请日：2008-07-16
申请人： Sung Youb Jung , Chang Ki Lim , Dae Hae Song , Sung Min Bae , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee
发明人： Sung Youb Jung , Chang Ki Lim , Dae Hae Song , Sung Min Bae , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee
IPC分类号： C07K14/605 , A61K38/26 , C07K14/46 , C07K14/575
CPC分类号： C07K14/46 , A61K38/26 , C07K14/57563 , C07K14/605
摘要： The present invention relates to an N-terminal amino acid-modified insulinotropic peptide having a high activity, and to a pharmaceutical composition comprising the same. The insulinotropic peptide derivatives according to the present invention exhibit therapeutic effects, which are not observed in native and other insulinotropic peptide analogs. Therefore, the insulinotropic peptide derivatives and the pharmaceutical composition comprising the same according to the present invention can be effectively provided for the treatment of the diseases.
摘要翻译： 本发明涉及具有高活性的N-末端氨基酸修饰的促胰岛素肽以及包含其的药物组合物。 根据本发明的促胰岛素肽衍生物显示出在天然和其他促胰岛素肽类似物中未观察到的治疗效果。 因此，可以有效地提供促胰岛素肽衍生物和包含其的本发明的药物组合物用于治疗疾病。
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公开(公告)号：US08476230B2
公开(公告)日：2013-07-02
申请号：US12523050
申请日：2008-01-04
申请人： Dae Hae Song , Chang Ki Lim , Tae Hun Song , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee , Sung Youb Jung , In Young Choi
发明人： Dae Hae Song , Chang Ki Lim , Tae Hun Song , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee , Sung Youb Jung , In Young Choi
IPC分类号： A61K38/00 , A61K39/395 , A61P5/50
CPC分类号： C07K14/57563 , A61K38/00 , A61K47/6835 , C07K14/605
摘要： The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and an immunoglobulin Fc region, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.
摘要翻译： 本发明涉及具有改善的功效和稳定性的体内持续时间的促胰岛素肽缀合物，其包含彼此共价连接的促胰岛素肽，非肽聚合物和免疫球蛋白Fc区，并且使用它们 。 本发明的促胰岛素肽缀合物具有保持较高的体内活性，并且血液半衰期显着增加，因此可以理想地用于开发各种肽药物的长效制剂。
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公开(公告)号：US20100105877A1
公开(公告)日：2010-04-29
申请号：US12523050
申请日：2008-01-04
申请人： Dae Hae Song , Chang Ki Lim , Tae Hun Song , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee , Sung Youb Jung , In Young Choi
发明人： Dae Hae Song , Chang Ki Lim , Tae Hun Song , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee , Sung Youb Jung , In Young Choi
IPC分类号： C07K16/00
CPC分类号： C07K14/57563 , A61K38/00 , A61K47/6835 , C07K14/605
摘要： The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and an immunoglobulin Fc region, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.
摘要翻译： 本发明涉及具有改善的功效和稳定性的体内持续时间的促胰岛素肽缀合物，其包含彼此共价连接的促胰岛素肽，非肽聚合物和免疫球蛋白Fc区，并且使用它们 。 本发明的促胰岛素肽缀合物具有保持较高的体内活性，并且血液半衰期显着增加，因此可以理想地用于开发各种肽药物的长效制剂。
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公开(公告)号：US20090238838A1
公开(公告)日：2009-09-24
申请号：US11947697
申请日：2007-11-29
申请人： Dae Jin Kim , Sung Min Bae , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee , Dae Hae Song , Young Hoon Kim
发明人： Dae Jin Kim , Sung Min Bae , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee , Dae Hae Song , Young Hoon Kim
CPC分类号： C07K19/00 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K2319/30
摘要： The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and a carrier substance, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.
摘要翻译： 本发明涉及具有改善的功效和稳定性的体内持续时间的促胰岛素肽缀合物，其包含彼此共价连接的促胰岛素肽，非肽聚合物和载体物质及其用途。 本发明的促胰岛素肽缀合物具有保持较高的体内活性，并且血液半衰期显着增加，因此可以理想地用于开发各种肽药物的长效制剂。
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公开(公告)号：US20080124347A1
公开(公告)日：2008-05-29
申请号：US11747153
申请日：2007-05-10
申请人： Young Min Kim , Dae Jin Kim , Sung Min Bae , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee , Dae Hae Song , Young Hoon Kim
发明人： Young Min Kim , Dae Jin Kim , Sung Min Bae , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee , Dae Hae Song , Young Hoon Kim
CPC分类号： A61K47/68 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and a carrier substance, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.
摘要翻译： 本发明涉及具有改善的功效和稳定性的体内持续时间的促胰岛素肽缀合物，其包含彼此共价连接的促胰岛素肽，非肽聚合物和载体物质及其用途。 本发明的促胰岛素肽缀合物具有保持较高的体内活性，并且血液半衰期显着增加，因此可以理想地用于开发各种肽药物的长效制剂。
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7.发明授权Immunoglobulin Fc fragment modified by non-peptide polymer and pharmaceutical composition comprising the same 有权通过非肽聚合物修饰的免疫球蛋白Fc片段和包含其的药物组合物公开(公告)号：US08124094B2
公开(公告)日：2012-02-28
申请号：US11910962
申请日：2005-04-28
申请人： Young Min Kim , Sung Min Bae , Dae Jin Kim , Dae Hae Song , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee
发明人： Young Min Kim , Sung Min Bae , Dae Jin Kim , Dae Hae Song , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee
IPC分类号： A61K39/00
CPC分类号： A61K47/6835 , A61K47/6811 , A61K47/6813 , C07K2317/52 , C07K2319/30
摘要： Disclosed are an Fc fragment modified by a non-peptide polymer, a pharmaceutical composition comprising the Fc fragment modified by the non-peptide polymer as a carrier, a complex of the Fc fragment and a drug via a linker and a pharmaceutical composition comprising such a complex. The Fc fragment modified by a non-peptide peptide according to the present invention lacks immunogenicity and effector functions. Due to these properties, the Fc fragment maintains the in vivo activity of a drug conjugated thereto in high levels, remarkably increases the serum half-life of the drug, and remarkably reduces the risk of inducing immune responses.
摘要翻译： 公开了由非肽聚合物修饰的Fc片段，包含由作为载体的非肽聚合物修饰的Fc片段的药物组合物，Fc片段的复合物和通过接头的药物和包含这样的 复杂。 由本发明的非肽肽修饰的Fc片段缺乏免疫原性和效应子功能。 由于这些性质，Fc片段以高水平维持与其结合的药物的体内活性，显着增加了药物的血清半衰期，并显着降低了诱导免疫应答的风险。
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8.发明申请IMMUNOGLOBULIN FC FRAGMENT MODIFIED BY NON-PEPTIDE POLYMER AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权非肽聚合物修饰的免疫球蛋白FC片段和包含其的药物组合物公开(公告)号：US20090053246A1
公开(公告)日：2009-02-26
申请号：US11910962
申请日：2005-04-28
申请人： Young Min Kim , Sung Min Bae , Dae Jin Kim , Dae Hae Song , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee
发明人： Young Min Kim , Sung Min Bae , Dae Jin Kim , Dae Hae Song , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee
CPC分类号： A61K47/6835 , A61K47/6811 , A61K47/6813 , C07K2317/52 , C07K2319/30
摘要： Disclosed are an Fc fragment modified by a non-peptide polymer, a pharmaceutical composition comprising the Fc fragment modified by the non-peptide polymer as a carrier, a complex of the Fc fragment and a drug via a linker and a pharmaceutical composition comprising such a complex. The Fc fragment modified by a non-peptide peptide according to the present invention lacks immunogenicity and effector functions. Due to these properties, the Fc fragment maintains the in vivo activity of a drug conjugated thereto in high levels, remarkably increases the serum half-life of the drug, and remarkably reduces the risk of inducing immune responses.
摘要翻译： 公开了由非肽聚合物修饰的Fc片段，包含由作为载体的非肽聚合物修饰的Fc片段的药物组合物，Fc片段的复合物和通过接头的药物和包含这样的 复杂。 由本发明的非肽肽修饰的Fc片段缺乏免疫原性和效应子功能。 由于这些性质，Fc片段以高水平维持与其结合的药物的体内活性，显着增加了药物的血清半衰期，并显着降低了诱导免疫应答的风险。
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9.发明申请PHARMACEUTICAL COMPOSITION FOR TREATING OBESITY-RELATED DISEASE COMPRISING INSULINOTROPIC PEPTIDE CONJUGATE 有权用于治疗包含胰岛素相关疾病的相关疾病的药物组合物公开(公告)号：US20100330108A1
公开(公告)日：2010-12-30
申请号：US12744660
申请日：2008-11-28
申请人： Dae Hae Song , Min Young Kim , Young Jin Park , Eun Hee Kang , Sung Youb Jung , Se Chang Kwon , Gwan Sun Lee
发明人： Dae Hae Song , Min Young Kim , Young Jin Park , Eun Hee Kang , Sung Youb Jung , Se Chang Kwon , Gwan Sun Lee
CPC分类号： C07K19/00 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K2319/30
摘要： The present invention relates to a composition for treating obesity-related diseases comprising an insulinotropic peptide conjugate, more particularly, to a composition for treating obesity-related diseases comprising a conjugate prepared by covalently linking the insulinotropic peptide with a carrier substance via a non-peptidyl linker, and a method for treating obesity-related diseases by using the same. In particular, the composition for treating obesity-related diseases according to the present invention remarkably improves the efficacy of suppressing food intake and its duration to reduce body weight and body fat, thereby being useful for the treatment of obesity-related diseases.
摘要翻译： 本发明涉及一种用于治疗肥胖相关疾病的组合物，其包括促胰岛素肽缀合物，更具体地，涉及用于治疗肥胖相关疾病的组合物，其包含通过非肽基共价连接促胰岛素肽与载体物质而制备的缀合物 接头，以及通过使用它们来治疗肥胖相关疾病的方法。 特别地，本发明的治疗肥胖相关疾病的组合物显着地提高了抑制食物摄取的效果及其减轻体重和体脂的持续时间，从而可用于治疗肥胖相关疾病。
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10.发明申请Pharmaceutical Composition Comprising An Immunoglobulin FC Region as a Carrier 有权包含免疫球蛋白FC区域作为载体的药物组合物公开(公告)号：US20100261248A1
公开(公告)日：2010-10-14
申请号：US12759801
申请日：2010-04-14
申请人： Young Min KIM , Dae Hae Song , Sung Youb Jung , Chang Hwan Kim , In Young Choi , Se Chang Kwon , Gwan Sun Lee
发明人： Young Min KIM , Dae Hae Song , Sung Youb Jung , Chang Hwan Kim , In Young Choi , Se Chang Kwon , Gwan Sun Lee
IPC分类号： C07K16/00 , C07K14/76 , C07K14/775 , C07K14/805 , C07K14/555 , C07K14/54 , C07K14/56 , C12N9/00 , C07K14/755
CPC分类号： C07K19/00 , A61K47/6811 , A61K47/6813 , A61K47/6835 , A61K2039/505 , C07K16/241 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/76 , C07K2319/30
摘要： Disclosed is a novel use of an immunoglobulin Fc fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier. The pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier remarkably extends the serum half-life of a drug while maintaining the in vivo activity of the drug at relatively high levels. Also, when the drug is a polypeptide drug, the pharmaceutical composition has less risk of inducing immune responses compared to a fusion protein of the immunoglobulin Fc fragment and a target protein, and is thus useful for developing long-acting formulations of various polypeptide drugs.
摘要翻译： 公开了免疫球蛋白Fc片段的新用途，更具体地，涉及包含免疫球蛋白Fc片段作为载体的药物组合物。 包含作为载体的免疫球蛋白Fc片段的药物组合物显着延长了药物的血清半衰期，同时保持药物的体内活性在相对高的水平。 此外，当药物是多肽药物时，与免疫球蛋白Fc片段和靶蛋白质的融合蛋白相比，药物组合物诱导免疫应答的风险较小，因此可用于开发各种多肽药物的长效制剂。
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