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11 条记录 (耗时 0.045 秒)

    AZA-benzothiophenyl compounds and methods of use
    4.
    发明申请
    AZA-benzothiophenyl compounds and methods of use 有权
    AZA-苯并噻吩基化合物及其使用方法

    公开(公告)号：US20080081821A1

    公开(公告)日：2008-04-03

    申请号：US11894345

    申请日：2007-08-20

    申请人： Pascal Savy ,  Stephen Price ,  Hazel Dyke ,  John Montana ,  Karen Williams ,  Mark Stanley ,  Liang Bao

    发明人： Pascal Savy ,  Stephen Price ,  Hazel Dyke ,  John Montana ,  Karen Williams ,  Mark Stanley ,  Liang Bao

    IPC分类号： A61K31/44 ,  A61P43/00 ,  C07D471/02

    CPC分类号： C07D495/04

    摘要： The invention relates to azabenzothiophenyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

    摘要翻译： 本发明涉及具有抗癌和/或抗炎活性的式I的氮杂苯并噻吩基化合物，更具体地涉及抑制MEK激酶活性的氮杂苯并噻吩基化合物。 本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。 本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

    Aza-benzofuranyl compounds and methods of use
    5.
    发明申请
    Aza-benzofuranyl compounds and methods of use 审中-公开
    氮杂 - 苯并呋喃基化合物及其使用方法

    公开(公告)号：US20080085886A1

    公开(公告)日：2008-04-10

    申请号：US11894506

    申请日：2007-08-20

    申请人： Pascal Savy ,  Stephen Price ,  Hazel Dyke ,  John Montana ,  Karen Williams ,  Mark Stanley ,  Liang Bao

    发明人： Pascal Savy ,  Stephen Price ,  Hazel Dyke ,  John Montana ,  Karen Williams ,  Mark Stanley ,  Liang Bao

    IPC分类号： A61K31/44 ,  A61K31/00 ,  A61K31/535 ,  A61P43/00 ,  C07D413/00 ,  C07D471/02

    CPC分类号： C07D491/048

    摘要： The invention relates to azabenzofuranyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

    摘要翻译： 本发明涉及具有抗癌和/或抗炎活性的式I的氮杂苯并呋喃基化合物，更具体地涉及抑制MEK激酶活性的氮杂苯并呋喃基化合物。 本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。 本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

    Hydroxamate sulfonamides as cd23 shedding inhibitors
    8.
    发明申请
    Hydroxamate sulfonamides as cd23 shedding inhibitors 审中-公开
    羟肟酸磺酰胺作为cd23脱落抑制剂

    公开(公告)号：US20060241118A1

    公开(公告)日：2006-10-26

    申请号：US10560119

    申请日：2004-06-18

    申请人： David Owen ,  Robert Watson ,  Daniel Allen ,  Andrew Sharpe ,  Hazel Dyke

    发明人： David Owen ,  Robert Watson ,  Daniel Allen ,  Andrew Sharpe ,  Hazel Dyke

    IPC分类号： A61K31/496 ,  A61K31/495 ,  C07D403/02 ,  C07D241/04

    CPC分类号： C07D295/26 ,  C07D211/34 ,  C07D309/04

    摘要： A class of piperazine and related heterocyclic derivatives, substituted at the 4-position by a substituted aryl or heteroaryl moiety, and at the 1-position by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

    摘要翻译： 一类哌嗪和相关的杂环衍生物，其在4-位被取代的芳基或杂芳基部分取代，在1-位被乙基磺酰基取代，乙基磺酰基又被异羟肟酸部分在2位上取代， 通过一系列替代取代基，作为CD23脱落的有效抑制剂，可用于治疗和/或预防过敏性，炎性和肿瘤性疾病。

    Hydroxamate sulfonamides as cd23 shedding inhibitors
    10.
    发明申请
    Hydroxamate sulfonamides as cd23 shedding inhibitors 审中-公开
    羟肟酸磺酰胺作为cd23脱落抑制剂

    公开(公告)号：US20060276507A1

    公开(公告)日：2006-12-07

    申请号：US10560327

    申请日：2004-06-18

    申请人： David Owen ,  Robert Watson ,  Daniel Allen ,  Andrew Sharpe ,  Hazel Dyke

    发明人： David Owen ,  Robert Watson ,  Daniel Allen ,  Andrew Sharpe ,  Hazel Dyke

    IPC分类号： C07D211/54 ,  A61K31/445

    CPC分类号： C07D211/96

    摘要： A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

    摘要翻译： 一类哌啶和相关的杂环衍生物，被取代的芳基或杂芳基部分C取代，并被乙基磺酰基取代，其又被异羟肟酸部分在2位上被取代，并且还被一系列替代物 作为CD23脱落的有效抑制剂的取代基可用于治疗和/或预防过敏性，炎性和肿瘤性疾病。