公开(公告)号：US20070227886A1

公开(公告)日：2007-10-04

申请号：US11691712

申请日：2007-03-27

申请人： Sunkam Vanaja ,  Mandapati Jayalakshmi ,  Sunkara Madhavendra ,  Kaki Rajgopal ,  Mannepalli Kantam ,  Sunkara Manorama ,  Vinod Khanna ,  Shamim Ahmad ,  Yogendra Jain ,  Chandra Shekhar

发明人： Sunkam Vanaja ,  Mandapati Jayalakshmi ,  Sunkara Madhavendra ,  Kaki Rajgopal ,  Mannepalli Kantam ,  Sunkara Manorama ,  Vinod Khanna ,  Shamim Ahmad ,  Yogendra Jain ,  Chandra Shekhar

IPC分类号： G01N27/26

CPC分类号： G01N33/84 ,  G01N33/521

摘要： The present invention relates to the development of a biosensor to determine potassium in human blood serum using dibenzo-18-crown-6 (DB18C6) as ionophore. Human blood serum contains potassium in ppm levels i.e. 137 to 200 mg/litre and sodium co exists with a 30 times higher concentration. Such a high concentration tends to interfere the selectivity towards potassium, but DB18C6 proves to have an excellent selectivity towards potassium and is highly sensitive to the lowest concentration of potassium levels present in the human blood serum. So the present invention reports the fabrication and characterization of ISFET (Ion Selective Field Effect transistor) coated with a monolayer of crown ether, dissolved in chloroform, on the gate of electrode.

摘要翻译： 本发明涉及使用二苯并-18-冠-6（DB18C6）作为离子载体来确定人血清中的钾的生物传感器的开发。 人血清中含有ppm水平的钾，即137至200mg /升，钠共存在30倍以上浓度。 这样高的浓度倾向于干扰对钾的选择性，但是DB18C6证明对钾具有优异的选择性，并且对人血清中存在的最低浓度的钾水平是高度敏感的。 因此，本发明报道了在电极栅极上涂覆有溶解在氯仿中的单层冠醚的ISFET（离子选择性场效应晶体管）的制造和表征。

公开(公告)号：US07790112B2

公开(公告)日：2010-09-07

申请号：US11691712

申请日：2007-03-27

申请人： Sunkam Vanaja ,  Mandapati Jayalakshmi ,  Sunkara Sakunthala Madhavendra ,  Kaki Rajgopal ,  Mannepalli Lakshmi Kantam ,  Sunkara Vardhireddy Manorama ,  Vinod Kumar Khanna ,  Shamim Ahmad ,  Yogendra Kumar Jain ,  Chandra Shekhar

发明人： Sunkam Vanaja ,  Mandapati Jayalakshmi ,  Sunkara Sakunthala Madhavendra ,  Kaki Rajgopal ,  Mannepalli Lakshmi Kantam ,  Sunkara Vardhireddy Manorama ,  Vinod Kumar Khanna ,  Shamim Ahmad ,  Yogendra Kumar Jain ,  Chandra Shekhar

IPC分类号： G01N27/26

CPC分类号： G01N33/84 ,  G01N33/521

摘要： The present invention relates to the development of a biosensor to determine potassium in human blood serum using dibenzo-18-crown-6 (DB18C6) as ionophore. Human blood serum contains potassium in ppm levels i.e 137 to 200 mg/litre and sodium co exists with a 30 times higher concentration. Such a high concentration tends to interfere the selectivity towards potassium, but DB18C6 proves to have an excellent selectivity towards potassium and is highly sensitive to the lowest concentration of potassium levels present in the human blood serum. So the present invention reports the fabrication and characterization of ISFET (Ion Selective Field Effect transistor) coated with a monolayer of crown ether, dissolved in chloroform, on the gate of electrode.

摘要翻译： 本发明涉及使用二苯并-18-冠-6（DB18C6）作为离子载体来确定人血清中的钾的生物传感器的开发。 人血清中含有ppm，即137至200 mg / L，钠含量高达30倍。 这样高的浓度倾向于干扰对钾的选择性，但是DB18C6证明对钾具有优异的选择性，并且对人血清中存在的最低浓度的钾水平是高度敏感的。 因此，本发明报道了在电极栅极上涂覆有溶解在氯仿中的单层冠醚的ISFET（离子选择性场效应晶体管）的制造和表征。

公开(公告)号：US08357275B2

公开(公告)日：2013-01-22

申请号：US12528758

申请日：2008-02-20

申请人： Sunkam Vanaja ,  Mandapati Jayalakshmi ,  Sunkara Sakunthala Madhavendra ,  Mandapati Mohan Rao ,  Mannepalli Lakshmi Kantam ,  Isukapally Margaret ,  Vinod Kumar Khanna ,  Shamim Ahmad ,  Yogendra Kumar Jain ,  Chandra Sekhar

发明人： Sunkam Vanaja ,  Mandapati Jayalakshmi ,  Sunkara Sakunthala Madhavendra ,  Mandapati Mohan Rao ,  Mannepalli Lakshmi Kantam ,  Isukapally Margaret ,  Vinod Kumar Khanna ,  Shamim Ahmad ,  Yogendra Kumar Jain ,  Chandra Sekhar

IPC分类号： G01N27/26 ,  G01N33/92 ,  G01N33/543 ,  H01L21/30

CPC分类号： G01N33/92 ,  G01N33/5438 ,  G01N2600/00

摘要： The present invention provides a novel sensor for the estimation of total cholesterol in human blood serum using molecular imprint of cholesterol. Human blood serum contains 150-250 mg/dl cholesterol. The present invention provides a sensor device and a process for the fabrication of ISFET (Ion Selective Field Effect Transister) coated with molecular imprint of cholesterol on the SiO2+Si3N4 dielectric gate of the said electrode. The molecular imprint of cholesterol (MIPC) anchored in to a silica matrix sensing material is identified as a sensing material which has specific selectivity towards the cholesterol in presence of other organic constituents in human blood serum.

摘要翻译： 本发明提供了一种用于使用胆固醇分子印记估计人血清中总胆固醇的新型传感器。 人血清含有150-250 mg / dl胆固醇。 本发明提供一种用于制造在所述电极的SiO 2 + Si 3 N 4电介质栅极上涂覆有胆固醇分子印迹的ISFET（离子选择性场效应转移）的传感器装置和方法。 锚定在二氧化硅基质感测材料中的胆固醇（MIPC）的分子印记被鉴定为在人血清中存在其它有机成分时对胆固醇具有特异性选择性的感测材料。

公开(公告)号：US20100147683A1

公开(公告)日：2010-06-17

申请号：US12528758

申请日：2008-02-20

申请人： Sunkam Vanaja ,  Mandapati Jayalakshmi ,  Sunkara Sakunthala Madhavendra ,  Mandapati Mohan Rao ,  Mannepalli Lakshmi Kantam ,  Isukapally Margaret ,  Vinod Kumar Khanna ,  Shamim Ahmad ,  Yogendra Kumar Jain ,  Chandra Sekhar

发明人： Sunkam Vanaja ,  Mandapati Jayalakshmi ,  Sunkara Sakunthala Madhavendra ,  Mandapati Mohan Rao ,  Mannepalli Lakshmi Kantam ,  Isukapally Margaret ,  Vinod Kumar Khanna ,  Shamim Ahmad ,  Yogendra Kumar Jain ,  Chandra Sekhar

IPC分类号： G01N33/92 ,  G01N27/26 ,  G01N33/543 ,  H01L21/30

CPC分类号： G01N33/92 ,  G01N33/5438 ,  G01N2600/00

摘要： The present invention provides a novel sensor for the estimation of total cholesterol in human blood serum using molecular imprint of cholesterol. Human blood serum contains 150-250 mg/dl cholesterol. The present invention provides a sensor device and a process for the fabrication of ISFET (Ion Selective Field Effect Transister) coated with molecular imprint of cholesterol on the SiO2+Si3N4 dielectric gate of the said electrode. The molecular imprint of cholesterol (MIPC) anchored in to a silica matrix sensing material is identified as a sensing material which has specific selectivity towards the cholesterol in presence of other organic constituents in human blood serum.

摘要翻译： 本发明提供了一种用于使用胆固醇分子印记估计人血清中总胆固醇的新型传感器。 人血清含有150-250 mg / dl胆固醇。 本发明提供一种用于制造在所述电极的SiO 2 + Si 3 N 4电介质栅极上涂覆有胆固醇分子印迹的ISFET（离子选择性场效应转移）的传感器装置和方法。 锚定在二氧化硅基质感测材料中的胆固醇（MIPC）的分子印记被鉴定为在人血清中存在其它有机成分时对胆固醇具有特异性选择性的感测材料。