公开(公告)号：US07790112B2

公开(公告)日：2010-09-07

申请号：US11691712

申请日：2007-03-27

申请人： Sunkam Vanaja ,  Mandapati Jayalakshmi ,  Sunkara Sakunthala Madhavendra ,  Kaki Rajgopal ,  Mannepalli Lakshmi Kantam ,  Sunkara Vardhireddy Manorama ,  Vinod Kumar Khanna ,  Shamim Ahmad ,  Yogendra Kumar Jain ,  Chandra Shekhar

发明人： Sunkam Vanaja ,  Mandapati Jayalakshmi ,  Sunkara Sakunthala Madhavendra ,  Kaki Rajgopal ,  Mannepalli Lakshmi Kantam ,  Sunkara Vardhireddy Manorama ,  Vinod Kumar Khanna ,  Shamim Ahmad ,  Yogendra Kumar Jain ,  Chandra Shekhar

IPC分类号： G01N27/26

CPC分类号： G01N33/84 ,  G01N33/521

摘要： The present invention relates to the development of a biosensor to determine potassium in human blood serum using dibenzo-18-crown-6 (DB18C6) as ionophore. Human blood serum contains potassium in ppm levels i.e 137 to 200 mg/litre and sodium co exists with a 30 times higher concentration. Such a high concentration tends to interfere the selectivity towards potassium, but DB18C6 proves to have an excellent selectivity towards potassium and is highly sensitive to the lowest concentration of potassium levels present in the human blood serum. So the present invention reports the fabrication and characterization of ISFET (Ion Selective Field Effect transistor) coated with a monolayer of crown ether, dissolved in chloroform, on the gate of electrode.

摘要翻译： 本发明涉及使用二苯并-18-冠-6（DB18C6）作为离子载体来确定人血清中的钾的生物传感器的开发。 人血清中含有ppm，即137至200 mg / L，钠含量高达30倍。 这样高的浓度倾向于干扰对钾的选择性，但是DB18C6证明对钾具有优异的选择性，并且对人血清中存在的最低浓度的钾水平是高度敏感的。 因此，本发明报道了在电极栅极上涂覆有溶解在氯仿中的单层冠醚的ISFET（离子选择性场效应晶体管）的制造和表征。

公开(公告)号：US20070227886A1

公开(公告)日：2007-10-04

申请号：US11691712

申请日：2007-03-27

申请人： Sunkam Vanaja ,  Mandapati Jayalakshmi ,  Sunkara Madhavendra ,  Kaki Rajgopal ,  Mannepalli Kantam ,  Sunkara Manorama ,  Vinod Khanna ,  Shamim Ahmad ,  Yogendra Jain ,  Chandra Shekhar

发明人： Sunkam Vanaja ,  Mandapati Jayalakshmi ,  Sunkara Madhavendra ,  Kaki Rajgopal ,  Mannepalli Kantam ,  Sunkara Manorama ,  Vinod Khanna ,  Shamim Ahmad ,  Yogendra Jain ,  Chandra Shekhar

IPC分类号： G01N27/26

CPC分类号： G01N33/84 ,  G01N33/521

摘要： The present invention relates to the development of a biosensor to determine potassium in human blood serum using dibenzo-18-crown-6 (DB18C6) as ionophore. Human blood serum contains potassium in ppm levels i.e. 137 to 200 mg/litre and sodium co exists with a 30 times higher concentration. Such a high concentration tends to interfere the selectivity towards potassium, but DB18C6 proves to have an excellent selectivity towards potassium and is highly sensitive to the lowest concentration of potassium levels present in the human blood serum. So the present invention reports the fabrication and characterization of ISFET (Ion Selective Field Effect transistor) coated with a monolayer of crown ether, dissolved in chloroform, on the gate of electrode.

摘要翻译： 本发明涉及使用二苯并-18-冠-6（DB18C6）作为离子载体来确定人血清中的钾的生物传感器的开发。 人血清中含有ppm水平的钾，即137至200mg /升，钠共存在30倍以上浓度。 这样高的浓度倾向于干扰对钾的选择性，但是DB18C6证明对钾具有优异的选择性，并且对人血清中存在的最低浓度的钾水平是高度敏感的。 因此，本发明报道了在电极栅极上涂覆有溶解在氯仿中的单层冠醚的ISFET（离子选择性场效应晶体管）的制造和表征。