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公开(公告)号:US06849446B2
公开(公告)日:2005-02-01
申请号:US09871212
申请日:2001-05-31
申请人: Suresh K. Tikoo , Lorne A. Babiuk , Linong Zhang , Qiaohua Wu
发明人: Suresh K. Tikoo , Lorne A. Babiuk , Linong Zhang , Qiaohua Wu
IPC分类号: C12N15/09 , A61K35/76 , A61K39/00 , A61K48/00 , A61P31/00 , A61P37/02 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/04 , C12N15/861 , C12N15/00
CPC分类号: C12N15/86 , A61K48/00 , A61K2039/5256 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/10362 , C12N2810/6018
摘要: The present invention provides modified bovine adenoviruses comprising a modification in a capsid protein wherein said protein is associated with adenovirus tropism and wherein said modification is associated with altered tropism. The present invention provides adenovirus vectors and host cells comprising such vectors. The present invention also provides methods of making and using such adenoviruses.
摘要翻译: 本发明提供了修饰的牛腺病毒,其包含衣壳蛋白中的修饰,其中所述蛋白质与腺病毒向性相关,并且其中所述修饰与改变的嗜性相关。 本发明提供了腺病毒载体和包含这种载体的宿主细胞。 本发明还提供了制备和使用这种腺病毒的方法。