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    Compositions and methods for therapeutic use
    5.
    发明授权
    Compositions and methods for therapeutic use 失效
    用于治疗用途的组合物和方法

    公开(公告)号：US07002027B1

    公开(公告)日：2006-02-21

    申请号：US08889355

    申请日：1997-07-08

    申请人： Heidrun Engler ,  Tattanahalli L. Nagabhushan ,  Stephen Kenneth Youngster

    发明人： Heidrun Engler ,  Tattanahalli L. Nagabhushan ,  Stephen Kenneth Youngster

    IPC分类号： C07J9/00 ,  C07H1/00

    CPC分类号： A61K48/00

    摘要： The present invention is directed to compositions and methods of treating cancer by gene therapy using a therapeutic gene formulated in a buffer comprising a delivery-enhancing agent. The delivery-enhancing agents of the invention can be used to formulate therapeutic or diagnostic agents, such as proteins, nucleic acids, antisense RNA, small molecules, etc., for administration to any tissue or organ having an epithelial membrane. The delivery-enhancing agents include detergents, alcohols, surfactants and other molecules.

    摘要翻译： 本发明涉及通过使用配制在包含递送增强剂的缓冲液中的治疗基因进行基因治疗来治疗癌症的组合物和方法。 本发明的递送增强剂可用于配制治疗或诊断试剂，例如蛋白质，核酸，反义RNA，小分子等，用于给予具有上皮膜的任何组织或器官。 递送增强剂包括洗涤剂，醇，表面活性剂和其它分子。

    COMPOSITIONS AND METHODS FOR THERAPEUTIC USE
    7.
    发明申请
    COMPOSITIONS AND METHODS FOR THERAPEUTIC USE 有权
    用于治疗用途的组合物和方法

    公开(公告)号：US20100028431A1

    公开(公告)日：2010-02-04

    申请号：US12422807

    申请日：2009-04-13

    申请人： Heidrun Engler ,  Tattanahalli L. Nagabhushan ,  Stephen Kenneth Youngster

    发明人： Heidrun Engler ,  Tattanahalli L. Nagabhushan ,  Stephen Kenneth Youngster

    IPC分类号： A61K9/10 ,  A61K31/70 ,  A61K31/7016 ,  A61K38/16 ,  A61K31/7088 ,  C08B37/00 ,  A61P35/00

    CPC分类号： A61K48/00

    摘要： A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I: wherein: n is an integer from 2-8; X1 is a cholic acid group or deoxycholic acid group; and X2 and X3 are each independently selected from the group consisting of a cholic acid group, a deoxycholic acid group, and a saccharide group, wherein the saccharide group is selected from the group consisting of pentose monosaccharide groups, hexose monosaccharide groups, pentose-pentose disaccharide groups, hexose-hexose disaccharide groups, pentose-hexose disaccharide groups, and hexose-pentose disaccharide groups; and wherein at least one of X2 and X3 is a saccharide group.

    摘要翻译： 一种用于增强治疗剂转移至细胞的方法和药物组合物，其中所述治疗剂配制在包含式I化合物的缓冲液中：其中：n为2-8的整数; X1是胆酸基或脱氧胆酸基; X2和X3各自独立地选自胆酸基，脱氧胆酸基和糖基，其中所述糖基选自戊糖单糖基，己糖单糖基，戊糖 - 戊糖基 二糖基团，己糖 - 己糖二糖基团，戊糖 - 己糖二糖基团和己糖 - 六糖二糖基团; 并且其中X 2和X 3中的至少一个是糖基团。

    Methods and compositions for interferon therapy
    8.
    发明申请
    Methods and compositions for interferon therapy 审中-公开
    用于干扰素治疗的方法和组合物

    公开(公告)号：US20050025742A1

    公开(公告)日：2005-02-03

    申请号：US10861654

    申请日：2004-06-04

    申请人： Heidrun Engler ,  Tattanahalli Nagabhushan ,  Stephen Youngster ,  Robert Connor

    发明人： Heidrun Engler ,  Tattanahalli Nagabhushan ,  Stephen Youngster ,  Robert Connor

    IPC分类号： A61K20060101 ,  A61K9/00 ,  A61K38/21 ,  A61K48/00

    CPC分类号： A61K9/0034 ,  A61K38/21

    摘要： Methods and pharmaceutical compositions for administering protein or gene therapy to tissues or organs having an epithelial cell layer are provided. A protein or nucleic acid encoding the protein is administered to the target tissue or organ in combination with treatment with a delivery enhancing agent which increases the delivery of the interferon or nucleic acid to the cells of the target tissues or organs. The methods and combinations are particularly useful in the treatment of cancers and other conditions responsive to interferon therapy. An exemplary method comprises the transurethral intravesical administration to the bladder of a therapeutically effective amount of a pharmaceutical composition comprising an alpha-interferon or a gene delivery system encoding the interferon and SYN3 or a SYN3 homolog or analog. In the urinary bladder, as much as a 10 to 1000 fold increased in interferon levels and activity may be observed with the use of a SYN3 formulation as opposed to a PBS formulation of the same interferon protein or interferon gene delivery system.

    摘要翻译： 提供了用于对具有上皮细胞层的组织或器官进行蛋白质或基因治疗的方法和药物组合物。 将编码蛋白质的蛋白质或核酸与目标组织或器官联合施用递送增强剂的组合施用，所述递送增强剂增加干扰素或核酸向靶组织或器官的细胞递送。 所述方法和组合在治疗癌症和其它对干扰素治疗有反应的病症方面特别有用。 示例性方法包括向膀胱经尿道膀胱内施用治疗有效量的药物组合物，其包含α-干扰素或编码干扰素和SYN3或SYN3同源物或类似物的基因递送系统。 在膀胱中，与使用相同干扰素蛋白或干扰素基因递送系统的PBS制剂相比，使用SYN3制剂可以观察到高达10至1000倍的干扰素水平和活性。

    Compositions and methods for therapeutic use
    10.
    发明授权
    Compositions and methods for therapeutic use 失效
    用于治疗用途的组合物和方法

    公开(公告)号：US07538093B2

    公开(公告)日：2009-05-26

    申请号：US11359997

    申请日：2006-02-21

    申请人： Heidrun Engler ,  Tattanahalli L. Nagabhushan ,  Stephen Kenneth Youngster

    发明人： Heidrun Engler ,  Tattanahalli L. Nagabhushan ,  Stephen Kenneth Youngster

    IPC分类号： A61K31/70 ,  C07J41/00

    CPC分类号： A61K48/00

    摘要： A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I: wherein: n is an integer from 2-8; X1 is a cholic acid group or deoxycholic acid group; and X2 and X3 are each independently selected from the group consisting of a cholic acid group, a deoxycholic acid group, and a saccharide group, wherein the saccharide group is selected from the group consisting of pentose monosaccharide groups, hexose monosaccharide groups, pentose-pentose disaccharide groups, hexose-hexose disaccharide groups, pentose-hexose disaccharide groups, and hexose-pentose disaccharide groups; and wherein at least one of X2 and X3 is a saccharide group.

    摘要翻译： 一种用于增强治疗剂转移至细胞的方法和药物组合物，其中所述治疗剂配制在包含式I化合物的缓冲液中：其中：n为2-8的整数; X1是胆酸基或脱氧胆酸基; X2和X3各自独立地选自胆酸基，脱氧胆酸基和糖基，其中所述糖基选自戊糖单糖基，己糖单糖基，戊糖 - 戊糖基 二糖基团，己糖 - 己糖二糖基团，戊糖 - 己糖二糖基团和己糖 - 六糖二糖基团; 并且其中X 2和X 3中的至少一个是糖基团。