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公开(公告)号：US07462351B2
公开(公告)日：2008-12-09
申请号：US11442653
申请日：2006-05-25
IPC分类号： A61K48/00 , C12N15/861
CPC分类号： C12N15/87 , A61K31/715 , A61K31/724 , A61K35/761 , A61K38/1758 , A61K48/00 , A61K48/0008 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , Y10S435/932 , A61K2300/00
摘要： The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced delivery of nucleic acids, particularly eucaryotic expression vectors, demonstrate enhanced delivery of nucleic acids to cells in vivo. The present invention also provides methods of treatment in combination with such formulations.
摘要翻译： 本发明提供了增强核酸向细胞递送的制剂和方法。 包含与糖组合的糊精聚合物的制剂提供增强的核酸递送，特别是真核表达载体，证明核酸在体内增强的细胞递送至细胞。 本发明还提供了与这些制剂组合的治疗方法。
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公开(公告)号：US20110104118A1
公开(公告)日：2011-05-05
申请号：US12912496
申请日：2010-10-26
CPC分类号： A61K47/186 , A61K9/0019 , A61K38/1709 , A61K47/10 , A61K48/00 , C07K14/4736 , C07K14/4746 , C12N15/87 , C12N2799/022
摘要： A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene such as p53 or a retinoblastoma tumor suppressor gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol or a detergent.
摘要翻译： 一种用于使用基因递送系统（例如病毒载体递送系统）治疗癌症的方法和药物组合物，其包含治疗性基因如p53或成视网膜细胞瘤肿瘤抑制基因，其中所述基因递送系统配制在包含递送 - 增强剂如乙醇或洗涤剂。
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公开(公告)号：US07094583B2
公开(公告)日：2006-08-22
申请号：US10913567
申请日：2004-08-06
IPC分类号： A61K48/00 , C12N15/866
CPC分类号： C12N15/87 , A61K31/715 , A61K31/724 , A61K35/761 , A61K38/1758 , A61K48/00 , A61K48/0008 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , Y10S435/932 , A61K2300/00
摘要： The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced delivery of nucleic acids, particularly eucaryotic expression vectors, demonstrate enhanced delivery of nucleic acids to cells in vivo. The present invention also provides methods of treatment in combination with such formulations.
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公开(公告)号：US6165779A
公开(公告)日：2000-12-26
申请号：US779627
申请日：1997-01-07
IPC分类号： A61K38/17 , A61K47/10 , A61K47/18 , A61K48/00 , C07K14/47 , C12N15/87 , C12N15/63 , A61K38/00 , C12N7/00
CPC分类号： A61K47/186 , A61K9/0019 , A61K38/1709 , A61K47/10 , A61K48/00 , C07K14/4736 , C07K14/4746 , C12N15/87 , C12N2799/022
摘要： A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene such as p53 or a retinoblastoma tumor suppressor gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol or a detergent.
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公开(公告)号：US20090048148A1
公开(公告)日：2009-02-19
申请号：US12058447
申请日：2008-03-28
IPC分类号： A61K48/00 , A61K38/02 , A61K31/7088 , A61P35/00
CPC分类号： A61K47/186 , A61K9/0019 , A61K38/1709 , A61K47/10 , A61K48/00 , C07K14/4736 , C07K14/4746 , C12N15/87 , C12N2799/022
摘要： A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene such as p53 or a retinoblastoma tumor suppressor gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol or a detergent.
摘要翻译： 一种用于使用基因递送系统（例如病毒载体递送系统）治疗癌症的方法和药物组合物，其包含治疗性基因如p53或成视网膜细胞瘤肿瘤抑制基因，其中所述基因递送系统配制在包含递送 - 增强剂如乙醇或洗涤剂。
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公开(公告)号：US20130302400A1
公开(公告)日：2013-11-14
申请号：US13815804
申请日：2013-03-15
IPC分类号： A61K47/48 , A61K31/56 , A61K31/7068
CPC分类号： A61K31/337 , A61K9/0019 , A61K31/37 , A61K31/42 , A61K31/56 , A61K31/573 , A61K31/706 , A61K31/7068 , A61K31/7076 , A61K31/7088 , A61K38/47 , A61K45/06 , A61K47/48215 , A61K47/48284 , A61K47/56 , A61K47/60 , A61K47/643 , C12N9/003 , C12N9/2474 , C12Y105/01003 , C12Y302/01035 , A61K2300/00
摘要： Provided herein is combination therapy containing an anti-hyaluronan agent, such as a polymer-conjugated hyaluronan-degrading enzyme, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.
摘要翻译： 本文提供了含有抗透明质酸药物如聚合物缀合的透明质酸降解酶和肿瘤靶向紫杉烷的组合疗法，以及任选的另外的化学治疗剂如核苷类似物。 联合治疗可用于治疗癌症，特别是实体瘤癌症的方法。
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公开(公告)号：US20090082289A1
公开(公告)日：2009-03-26
申请号：US11800036
申请日：2007-05-02
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10332 , C12N2710/10343 , C12N2830/008 , C12N2830/85
摘要： This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant proteins and gene therapy also are included within the scope of this invention.Thus, for example, the adenoviral vector of this invention- can contain a foreign gene for the expression of a protein effective in regulating the cell cycle, such as p53, Rb, or mitosin, or in inducing cell death, such as the conditional suicide gene thymidine kinase. (The latter must be used in conjunction with a thymidine kinase metabolite in order to be effective).
摘要翻译： 本发明提供一种重组腺病毒表达载体，其特征在于部分或完全缺失腺病毒蛋白IX DNA并具有编码外来蛋白或其功能片段或突变体的基因。 转化的宿主细胞和生产重组蛋白和基因治疗的方法也包括在本发明的范围内。 因此，例如，本发明的腺病毒载体可以含有外源基因，用于表达有效调节细胞周期的蛋白质，例如p53，Rb或mitosin，或诱导细胞死亡，例如有条件的自杀 基因胸苷激酶。 （后者必须与胸苷激酶代谢物结合使用才能有效）。
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公开(公告)号：US20080182807A1
公开(公告)日：2008-07-31
申请号：US11603279
申请日：2006-11-20
IPC分类号： A61K31/7052 , A61P35/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10332 , C12N2710/10343 , C12N2830/008 , C12N2830/85
摘要： This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant proteins and gene therapy also are included within the scope of this invention.Thus, for example, the adenoviral vector of this invention can contain a foreign gene for the expression of a protein effective in regulating the cell cycle, such as p53, Rb, or mitosin, or in inducing cell death, such as the conditional suicide gene thymidine kinase. (The latter must be used in conjunction with a thymidine kinase metabolite in order to be effective).
摘要翻译： 本发明提供一种重组腺病毒表达载体，其特征在于部分或完全缺失腺病毒蛋白IX DNA并具有编码外来蛋白或其功能片段或突变体的基因。 转化的宿主细胞和生产重组蛋白和基因治疗的方法也包括在本发明的范围内。 因此，例如，本发明的腺病毒载体可以含有外源基因，用于表达有效调节细胞周期的蛋白质，如p53，Rb或mitosin，或诱导细胞死亡，如条件性自杀基因 胸苷激酶。 （后者必须与胸苷激酶代谢物结合使用才能有效）。
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公开(公告)号：US20080175818A1
公开(公告)日：2008-07-24
申请号：US11739963
申请日：2007-04-25
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10332 , C12N2710/10343 , C12N2830/008 , C12N2830/85
摘要： This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant proteins and gene therapy also are included within the scope of this invention.Thus, for example, the adenoviral vector of this invention can contain a foreign gene for the expression of a protein effective in regulating the cell cycle, such as p53, Rb, or mitosin, or in inducing cell death, such as the conditional suicide gene thymidine kinase. (The latter must be used in conjunction with a thymidine kinase metabolite in order to be effective).
摘要翻译： 本发明提供一种重组腺病毒表达载体，其特征在于部分或完全缺失腺病毒蛋白IX DNA并具有编码外来蛋白或其功能片段或突变体的基因。 转化的宿主细胞和生产重组蛋白和基因治疗的方法也包括在本发明的范围内。 因此，例如，本发明的腺病毒载体可以含有外源基因，用于表达有效调节细胞周期的蛋白质，如p53，Rb或mitosin，或诱导细胞死亡，如条件性自杀基因 胸苷激酶。 （后者必须与胸苷激酶代谢物结合使用才能有效）。
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10.发明授权Method of using an adenoviral vector encoding a retinoblastoma protein to treat hyperproliferating cells 失效使用编码视网膜母细胞瘤蛋白质的腺病毒载体来治疗过度增殖细胞的方法公开(公告)号：US07105156B1
公开(公告)日：2006-09-12
申请号：US08472760
申请日：1995-06-07
申请人： Wen-Hwa Lee , H. Michael Shepard , Richard J. Gregory , Ken N. Wills , Daniel C. Maneval , Eva Lee , David Goodrich , Nan-Ping Wang
发明人： Wen-Hwa Lee , H. Michael Shepard , Richard J. Gregory , Ken N. Wills , Daniel C. Maneval , Eva Lee , David Goodrich , Nan-Ping Wang
CPC分类号： A61K38/1709 , A61K48/005 , C07K14/4736 , C12N2710/10043
摘要： Disclosed are methods of controlling cell cycle progression by introducing into a cell to be controlled a composition selected from the group consisting of p56RB protein, a fragment of the p56RB protein, and the gene encoding p56RB protein to alter the cell cycle progression while maintaining the viability of the cell. The p56RB protein has been found to have the unexpected and surprising characteristic of being soluble in low concentrations of glycerol, thereby enhancing its value in pharmaceutical applications and the gene encoding p56RB when delivered to the hyperproliferating cell inhibits cellular proliferation.
摘要翻译： 公开了通过将细胞引入被控制的细胞中来控制细胞周期进程的方法，所述细胞选自由p56Rb蛋白质组成的组，p56RB蛋白质的片段， 和编码p56PN蛋白的基因，以改变细胞周期进程，同时保持细胞的活力。 已经发现p56RBP蛋白具有可溶于低浓度甘油的意想不到的令人惊奇的特征，从而提高了其在药物应用中的价值，并且编码p56Rb / 当递送到过度增殖细胞时抑制细胞增殖。
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