公开(公告)号：US07541025B2

公开(公告)日：2009-06-02

申请号：US10786094

申请日：2004-02-26

申请人： Susumu Ikehara ,  Yasushi Adachi ,  Yasuhiro Suzuki

发明人： Susumu Ikehara ,  Yasushi Adachi ,  Yasuhiro Suzuki

IPC分类号： A61K35/12 ,  A61K35/14 ,  C12N5/06 ,  C12N5/08 ,  A61N5/10

CPC分类号： A61K35/28 ,  A61K35/17

摘要： The invention provides a technology which utilizes donor lymphocyte infusion and by which malignant tumor can be treated without causing such an adverse effect as graft versus host disease. Thus, a method for the treatment of malignant tumor is provided which comprises performing, in a patient requiring such treatment, donor lymphocyte infusion for the graft versus tumor reaction-based treatment of tumor and then performing radiation treatment, infusion of lymphocytes derived from the host or a third party identical in HLA type to the host, and intra bone marrow-bone marrow transplantation using bone marrow cells derived from the host or a third party identical in HLA type to the host, for the prevention and treatment of the graft versus host disease induced by the donor lymphocyte infusion.

摘要翻译： 本发明提供一种利用供体淋巴细胞输注的技术，通过其可以治疗恶性肿瘤而不引起移植物抗宿主病的不利影响。 因此，提供了治疗恶性肿瘤的方法，其包括在需要这种治疗的患者中进行供体淋巴细胞输注用于基于肿瘤反应的移植物治疗，然后进行放射治疗，输入源自宿主的淋巴细胞 或HLA类型与宿主相同的第三方，以及使用衍生自宿主的骨髓细胞或HLA型与宿主相同的第三方进行骨髓 - 骨髓移植，用于预防和治疗移植物抗宿主 由供体淋巴细胞输注引起的疾病。

公开(公告)号：US20060247552A1

公开(公告)日：2006-11-02

申请号：US11487962

申请日：2006-06-27

申请人： Susumu Ikehara ,  Shuji Nakamura ,  Masato Aoki ,  Masaaki Numazawa ,  Masakazu Adachi

发明人： Susumu Ikehara ,  Shuji Nakamura ,  Masato Aoki ,  Masaaki Numazawa ,  Masakazu Adachi

IPC分类号： A61B10/00

CPC分类号： A61B10/025 ,  A61B10/0096 ,  A61B17/1637 ,  A61B2010/0258

摘要： The bone marrow harvesting set according to the invention includes: a centrifuge container used for harvesting bone marrow; a cap with a collection inlet; and a collection tube with connectors attached to both ends thereof, the set being constructed in such a manner as to put the cap on the centrifuge container, fit one of the connectors into the collection inlet of the cap, and fit the other connector into the mantle of the bone marrow harvesting needle so as to collect bone marrow. The bone marrow harvesting needle includes: a tubular mantle and an inner needle with its tip allowed to project from the mantle, the inner needle having a drilling edge formed at its tip and the mantle having a cutting edge formed at its tip.

摘要翻译： 根据本发明的骨髓采集装置包括：用于收获骨髓的离心容器; 带收集入口的帽子; 以及收纳管，其连接器连接到其两端，所述组件以将盖放置在离心机容器上的方式构造，将一个连接器装配到盖的收集入口中，并将另一个连接器装配到 骨髓采集针头，以收集骨髓。 骨髓采集针包括：管状地幔和内针，其顶端允许从地幔突出，内针具有形成在其顶端处的钻孔边缘，并且幔具有在其尖端处形成的切割边缘。

公开(公告)号：US08070690B2

公开(公告)日：2011-12-06

申请号：US12018337

申请日：2008-01-23

申请人： Susumu Ikehara ,  Hiroshi Shirafuji ,  Shuji Nakamura ,  Nobuo Shimoda ,  Katsuyuki Sado

发明人： Susumu Ikehara ,  Hiroshi Shirafuji ,  Shuji Nakamura ,  Nobuo Shimoda ,  Katsuyuki Sado

IPC分类号： A61B10/02

CPC分类号： A61B10/025 ,  A61B17/1617 ,  A61B17/1633 ,  A61B17/1635 ,  A61B17/17 ,  A61B2010/0258

摘要： The bone marrow harvesting drill of the invention includes an inner needle having a cutting edge at the tip thereof; a tubular mantle that receives the inner needle thereinto so that the inner needle and the tubular mantle are detachably attached; and a lock mechanism that prevents the axial rotation of the tubular mantle and the inner needle relative to each other; the inner needle having a groove formed at the tip thereof projecting from the tubular mantle for discharging bone scraps produced by the cutting edge at the tip of the inner needle; and the tubular mantle having a cutting edge formed at the tip edge thereof and a helical groove extending from the tip edge to at least part of the peripheral surface of the tubular mantle so as to be flush with the groove of the inner needle.

摘要翻译： 本发明的骨髓采集钻头包括在其顶端具有切割边缘的内针; 将内针容纳在其中的管状罩体，使得内针和管状罩可拆卸地安装; 以及防止管状罩和内针相对于彼此的轴向旋转的锁定机构; 所述内针具有形成在其尖端处的从所述管状罩突出的槽，用于排出由所述内针的尖端处的所述切割刃产生的骨屑; 并且所述管状壁具有形成在其前端缘处的切削刃，以及螺旋槽，其从所述前端边缘延伸到所述管状套管的周面的至少一部分，以与所述内针的槽齐平。

公开(公告)号：US06383481B1

公开(公告)日：2002-05-07

申请号：US09265418

申请日：1999-03-10

申请人： Susumu Ikehara ,  Muneo Inaba ,  Kenji Takeuchi ,  Taketoshi Kushida

发明人： Susumu Ikehara ,  Muneo Inaba ,  Kenji Takeuchi ,  Taketoshi Kushida

IPC分类号： A61K3528

CPC分类号： A61K41/00 ,  A61K2035/122

摘要： This invention relates to a method of transplanting hemopoietic stem cells which Comprises subjecting a recipient to a radiation treatment using an effective exposure dose for hemopoietic stem cell transplantation in advance and administering hemopoietic stem cells from a donor from the portal vein. By this method the graft failure/rejection of donor cells can be avoided to thereby maintain the transplant in satisfactory condition.

摘要翻译： 本发明涉及一种移植造血干细胞的方法，该方法包括使用预先造血干细胞移植的有效暴露剂量对接受者进行放射治疗并从门静脉施用来自供体的造血干细胞。 通过该方法，可以避免供体细胞的移植物衰竭/排斥，从而将移植保持在令人满意的状态。