公开(公告)号：US5047540A

公开(公告)日：1991-09-10

申请号：US284590

申请日：1988-11-29

申请人： Susumu Kamata ,  Tatsuo Tsuri ,  Nobuhiro Haga ,  Takeaki Matsui ,  Morio Kishi ,  Kimio Takahashi ,  Sanji Hagashita ,  Kaoru Seno

发明人： Susumu Kamata ,  Tatsuo Tsuri ,  Nobuhiro Haga ,  Takeaki Matsui ,  Morio Kishi ,  Kimio Takahashi ,  Sanji Hagashita ,  Kaoru Seno

IPC分类号： C07C311/32 ,  C07C311/46 ,  C07C323/49 ,  C07C391/00 ,  C07D213/20 ,  C07D215/10 ,  C07D217/10 ,  C07D241/12 ,  C07D249/14 ,  C07D261/12 ,  C07D277/22 ,  C07D277/62 ,  C07D295/088 ,  C07D413/12 ,  C07D521/00

CPC分类号： C07D213/20 ,  C07C311/32 ,  C07C311/46 ,  C07C323/49 ,  C07C391/00 ,  C07D215/10 ,  C07D217/10 ,  C07D231/12 ,  C07D233/56 ,  C07D241/12 ,  C07D249/08 ,  C07D261/12 ,  C07D277/22 ,  C07D277/62 ,  C07D295/088 ,  C07D413/12

摘要： Lipid derivatives represented by the formula: ##STR1## wherein R.sub.1 is alkyl or alkylcarbamoyl; R.sub.2 is lower alkyloxy, lower alkylcarbamoyloxy, lower alkylcarbonylamino, lower alkyloxycarbonylamino, lower alkylureido, lower alkyloxymethyl, lower alkylcarbonylmethyl, cyanomethyl, heterocyclic group, or he0 terocyclyloxy; R.sub.2 ' is hydrogen or R.sub.2 and R.sub.2 ' taken together form --O(CH.sub.2).sub.m -- wherein m is an integer of 1 to 5; R.sub.3, R.sub.4, and R.sub.5 each is hydrogen or lower alkyl or two or three of R.sub.3, R.sub.4, and R.sub.5 taken together with the adjacent nitrogen atom form cyclic ammonio; R.sub.6 is hydrogen or lower alkylcarbonyl; X.sup.- is a counter anion; Y is oxygen or sulfur; and n is an integer of 1 to 10, being useful as PAF antagonists, e.g., as antithrombotic, antivasoconstricting, antibronchoconstricting agent or antitumor agent.

公开(公告)号：US5138067A

公开(公告)日：1992-08-11

申请号：US707164

申请日：1991-05-29

申请人： Susumu Kamata ,  Tatsuo Tsuri ,  Nobuhiro Haga ,  Takeaki Matsui ,  Morio Kishi ,  Kimio Takahashi ,  Sanji Hagishita ,  Kaoru Seno

发明人： Susumu Kamata ,  Tatsuo Tsuri ,  Nobuhiro Haga ,  Takeaki Matsui ,  Morio Kishi ,  Kimio Takahashi ,  Sanji Hagishita ,  Kaoru Seno

IPC分类号： C07C311/32 ,  C07C311/46 ,  C07C323/49 ,  C07C391/00 ,  C07D213/20 ,  C07D215/10 ,  C07D217/10 ,  C07D241/12 ,  C07D261/12 ,  C07D277/22 ,  C07D277/62 ,  C07D295/088 ,  C07D413/12 ,  C07D521/00

CPC分类号： C07D213/20 ,  C07C311/32 ,  C07C311/46 ,  C07C323/49 ,  C07C391/00 ,  C07D215/10 ,  C07D217/10 ,  C07D231/12 ,  C07D233/56 ,  C07D241/12 ,  C07D249/08 ,  C07D261/12 ,  C07D277/22 ,  C07D277/62 ,  C07D295/088 ,  C07D413/10

摘要： Lipid derivatives represented by the formula: ##STR1## wherein R.sub.1 is alkyl or alkylcarbamoyl; R.sub.2 is lower alkyloxy, lower alkylcarbamoyloxy, lower alkylcarbonylamino, lower alkyloxycarbonylamino, lower alkylureido, lower alkyloxymethyl, lower alkylcarbonylmethyl, cyanomethyl, heterocyclic group, or heterocyclyloxy; R.sub.2 ' is hydrogen or R.sub.2 and R.sub.2 ' taken together with R.sub.2 form --O(CH.sub.2).sub.m -- wherein m is an integer of 1 to 5; R.sub.3, R.sub.4, and R.sub.5 each is hydrogen or lower alkyl or two or three of R.sub.3, R.sub.4, and R.sub.5 taken together with the adjacent nitrogen atom form cyclic ammonio; R.sub.6 is hydrogen or lower alkylcarbonyl; X.sup.- is a counter anion; Y is oxygen or sulfur; and n is an integer of 1 to 10, being useful as PAF antagonists, e.g., as antithrombotic, antivasoconstricting, antibronchoconstricting agent or antitumor agent.

摘要翻译： 由下式表示的脂质衍生物：其中R1是烷基或烷基氨基甲酰基; 低级烷氧基羰基氨基，低级烷基脲基，低级烷氧基甲基，低级烷基羰基甲基，氰基甲基，杂环基或杂环氧基; R2'是氢或R2和R2'与R2一起形成-O（CH 2）m - ，其中m是1至5的整数; R 3，R 4和R 5各自为氢或低级烷基或R 3，R 4和R 5中的两个或三个与相邻的氮原子一起形成环状铵; R6是氢或低级烷基羰基; X-是抗衡阴离子; Y是氧或硫; n为1〜10的整数，可用作PAF拮抗剂，例如作为抗血栓形成，抗收缩性抗静电收缩剂或抗肿瘤剂。

公开(公告)号：US5585501A

公开(公告)日：1996-12-17

申请号：US453773

申请日：1995-05-30

申请人： Mitsuaki Ohtani ,  Takaharu Matsuura ,  Yoshinori Hamada ,  Isamu Yamada ,  Teruo Sakata ,  Kimio Takahashi ,  Morio Kishi

发明人： Mitsuaki Ohtani ,  Takaharu Matsuura ,  Yoshinori Hamada ,  Isamu Yamada ,  Teruo Sakata ,  Kimio Takahashi ,  Morio Kishi

IPC分类号： C07D307/935 ,  C07D307/83

CPC分类号： C07D307/935

摘要： A method for reduction of an allyl alcohol-type compound, specific to its allylic hydroxyl group, being carried out without any side reactions such as reduction of other portions of the compound or allylic rearrangement, which comprises treating the compound with trialkylsilane in the presence of AlX.sub.3, wherein X refers to a halogen atom.

摘要翻译： 一种还原其烯丙基羟基特异性烯丙醇型化合物的方法进行而无任何副反应，例如化合物其它部分的还原或烯丙基重排，其包括在三烷基硅烷存在下处理该化合物 AlX3，其中X表示卤素原子。

公开(公告)号：US5292754A

公开(公告)日：1994-03-08

申请号：US948179

申请日：1992-09-21

申请人： Morio Kishi ,  Kimio Takahashi ,  Kenji Kawada ,  Yasumasa Goh

发明人： Morio Kishi ,  Kimio Takahashi ,  Kenji Kawada ,  Yasumasa Goh

IPC分类号： C07C405/00 ,  A61K31/557

CPC分类号： C07C405/00 ,  Y10S206/828 ,  Y10S514/913

摘要： The present invention relates to a method for treating hypertension or glaucoma in the eye comprising contacting the surface of the eye with a therapeutic amount of a 15-deoxyprostaglandin derivative of the formula (I): ##STR1## in which ##STR2## is a 5 membered ring which is selected from a group consisting of ##STR3## R.sup.1 is hydrogen or lower alkyl; R.sup.2 is C.sub.6 -C.sub.12 alkyl, C.sub.6 -C.sub.12 alkenyl or C.sub.6 -C.sub.12 alkadienyl or a pharmaceutically acceptable salt thereof. The invention also relates to a kit for delivery of a topical solution for treatment of glaucoma which comprises (a) container having a solution including a compound of the formula (I), and (b) means for topical delivery of said solution to the eye in a controlled dosage.

摘要翻译： 本发明涉及一种用于治疗眼睛中的高血压或青光眼的方法，包括使眼表面与治疗量的式（I）的15-脱氧前列腺素衍生物接触：（*化学结构*）（I），其中 （*化学结构*）是选自（*化学结构*）R 1为氢或低级烷基的5元环; R2是C6-C12烷基，C6-C12链烯基或C6-C12链二烯基或其药学上可接受的盐。 本发明还涉及一种用于递送用于治疗青光眼的局部用溶液的试剂盒，其包含（a）具有包含式（I）化合物的溶液的容器，和（b）将所述溶液局部递送至眼睛的装置 以受控剂量。

公开(公告)号：US5599837A

公开(公告)日：1997-02-04

申请号：US395642

申请日：1995-02-28

申请人： Morio Kishi ,  Kimio Takahashi ,  Kenji Kawada ,  Yasumasa Goh

发明人： Morio Kishi ,  Kimio Takahashi ,  Kenji Kawada ,  Yasumasa Goh

IPC分类号： A61K31/557 ,  A61P27/06 ,  C07C405/00

CPC分类号： C07C405/00

摘要： The present invention relates to a 15-deoxyprostaglandin derivative of the formula (I): ##STR1## in which ##STR2## is a 5 membered ring which is selected from a group consisting of ##STR3## R.sup.1 is hydrogen or lower alkyl; R.sup.2 is C.sub.6 -C.sub.12 alkyl, C.sub.6 -C.sub.12 alkenyl or C.sub.6 -C.sub.12 alkadienyl;provided that the compound of the following formula is excluded: ##STR4## wherein R' is hydrogen or methyl; or pharmaceutically acceptable salts thereof. The invention also relates to a pharmaceutical formulation comprising a 15-deoxyprostaglandin derivative as an active ingredient, which is useful as an intraocular pressure reducing agent.

摘要翻译： 本发明涉及式（I）的15-脱氧前列腺素衍生物：其中是一种5元环，其选自由下列组成的组：R1是氢 或低级烷基; R2是C6-C12烷基，C6-C12链烯基或C6-C12链二烯基; 条件是排除下列化学式的化合物：其中R'是氢或甲基; 或其药学上可接受的盐。 本发明还涉及含有作为活性成分的15-脱氧前列腺素衍生物的药物制剂，其可用作眼内压降低剂。

公开(公告)号：US07395903B2

公开(公告)日：2008-07-08

申请号：US11396626

申请日：2006-04-04

申请人： Kimio Takahashi ,  Kazuhiro Sekiguchi ,  Hideaki Takahashi

发明人： Kimio Takahashi ,  Kazuhiro Sekiguchi ,  Hideaki Takahashi

IPC分类号： F16D55/08

CPC分类号： F16D65/18 ,  F16D65/22 ,  F16D2121/28

摘要： An actuator 23d for pushing a plurality of friction plates 44, 44 to a plurality of plates 37, 37 to be braked is composed of members including electroactive polymer, the shape of the elastomer of which is changed by electric energy.

摘要翻译： 用于将多个摩擦板44,44推压到制动的多个板37,37的致动器23d由包含电活性聚合物的构件组成，弹性体的形状由电能改变。

公开(公告)号：US07303829B2

公开(公告)日：2007-12-04

申请号：US10839511

申请日：2004-05-05

申请人： Kimio Takahashi ,  Sachie Shoji

发明人： Kimio Takahashi ,  Sachie Shoji

IPC分类号： G11B5/66 ,  G11B5/70

CPC分类号： G11B5/738

摘要： There is provided a magnetic recording medium having an extremely thin magnetic layer, in which, not only corrosion of the magnetic layer is suppressed, but also the storage properties and the electromagnetic conversion properties are improved. The magnetic recording medium comprises: an elongated nonmagnetic substrate; a first shielding layer comprised of a metal or an alloy; a second shielding layer comprised of a material which is more hardly oxidized than the first shielding layer, and a magnetic layer, formed by a vacuum thin film formation technique, having a thickness of 55 nm or less. A total thickness of the first shielding layer and the second shielding layer is 2 to 50 nm.

摘要翻译： 提供了具有极薄的磁性层的磁记录介质，其中不仅抑制了磁性层的腐蚀，而且提高了存储性能和电磁转换性能。 磁记录介质包括：细长非磁性基片; 由金属或合金构成的第一屏蔽层; 由比第一屏蔽层更难以氧化的材料构成的第二屏蔽层和厚度为55nm以下的由真空薄膜形成技术形成的磁性层。 第一屏蔽层和第二屏蔽层的总厚度为2〜50nm。

公开(公告)号：US20070062764A1

公开(公告)日：2007-03-22

申请号：US11523500

申请日：2006-09-20

申请人： Hideaki Takahashi ,  Kimio Takahashi

发明人： Hideaki Takahashi ,  Kimio Takahashi

IPC分类号： F16D66/00

CPC分类号： F16D65/18 ,  B60T13/746 ,  F16D2066/003 ,  F16D2066/006 ,  F16D2121/24

摘要： Pistons 3 and 7 are pressed to a friction member 11 at two points that are positioned at a rotating-in side and a rotating-out side in a rotating direction of a brake rotor 10. An axial force control is performed for the piston 3 on the rotating-out side, and a position control based on the position of the piston 3 on the rotating-out side is performed for the piston 7 on the rotating-in side.

摘要翻译： 活塞3和7在制动转子10的旋转方向上位于旋转侧和转出侧的两个点处被按压到摩擦构件11。 对旋转一侧的活塞3进行轴向力控制，对活塞7在旋转侧进行基于活塞3在旋转侧的位置的位置控制。

公开(公告)号：US20060284202A1

公开(公告)日：2006-12-21

申请号：US11443192

申请日：2006-05-31

申请人： Naohiro Nakane ,  Kimio Takahashi

发明人： Naohiro Nakane ,  Kimio Takahashi

IPC分类号： H01L33/00

CPC分类号： H01L25/046 ,  H01L27/1214 ,  H01L27/3276 ,  H01L27/3293 ,  H01L2251/566 ,  H01L2924/0002 ,  H01L2924/00

摘要： There are provided an electronic component production method and an electronic component by which the number of scribing processes can be reduced and the productivity can be made higher while surely preventing short circuiting during the production. An electronic component including a short ring residue portion and a method of producing the electronic component are provided.

摘要翻译： 提供了电子部件制造方法和电子部件，通过该电子部件的制造方法可以减少划线处理的数量，并且可以在确保防止生产中的短路的同时，提高生产率。 提供了包括短环残留部分的电子部件和制造电子部件的方法。

公开(公告)号：US20050196647A1

公开(公告)日：2005-09-08

申请号：US11118247

申请日：2005-04-29

申请人： Kimio Takahashi

发明人： Kimio Takahashi

IPC分类号： G11B5/738 ,  G11B5/65 ,  G11B5/73 ,  G11B5/735 ,  G11B5/147

CPC分类号： G11B5/7325

摘要： A magnetic recording medium having good corrosion resistance, electromagnetic conversion characteristics and storability is obtained. In a magnetic recording medium including a foundation layer and a magnetic layer having a thickness of 55 nm or less, which is formed by a vacuum thin film forming technique, on one principal surface of an elongate non-magnetic substrate, the foundation layer is made of a silicon nitride film having a thickness of 2 nm to 50 nm. A magneto-resistive magnetic head or a giant magneto-resistive magnetic head is slid on the magnetic recording medium so as to record and reproduce signals.