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    Aminoalkylpyrrolidinylthiocarbapenem derivatives
    9.
    发明授权
    Aminoalkylpyrrolidinylthiocarbapenem derivatives 失效
    氨基烷基吡咯烷基硫代碳青霉烯衍生物

    公开(公告)号：US5550121A

    公开(公告)日：1996-08-27

    申请号：US312619

    申请日：1994-09-27

    申请人： Susumu Nakagawa ,  Shinji Kato ,  Satoshi Murase ,  Osamu Okamoto ,  Ryuji Mitomo ,  Katsumi Yamamoto ,  Koji Yamada ,  Hiroshi Fukatsu

    发明人： Susumu Nakagawa ,  Shinji Kato ,  Satoshi Murase ,  Osamu Okamoto ,  Ryuji Mitomo ,  Katsumi Yamamoto ,  Koji Yamada ,  Hiroshi Fukatsu

    IPC分类号： C07D207/12 ,  C07D477/20 ,  C07D487/04 ,  A61K31/40

    CPC分类号： C07D477/20 ,  C07D207/12

    摘要： A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a methyl group, R.sup.2 is a hydrogen atom or a negative charge, R.sup.3 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkoxy group, a lower alkanoyloxy group, an amino group, an N-lower alkylamino group, an N,N-di-lower alkylamino group, a lower alkanoylamino group, an aroylamino group, a (lower alkylsulfonyl)amino group, a sulfamoylamino group, a cyano group, a nitro group, a group of --COOR.sup.4 (wherein R.sup.4 is a hydrogen atom or a lower alkyl group) or a group of --CON(R.sup.5)R.sup.6 (wherein each of R.sup.5 and R.sup.6 which may be the same or different, is a hydrogen atom or a lower alkyl group, or R.sup.5 and R.sup.6 form together with the adjacent nitrogen atom a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidyl group, a piperazinyl group, a 4-lower alkyl piperazinyl group and a morpholino group), A is a linear or branched lower alkylene group, X is a group of --N(R.sup.7)R.sup.8 (wherein each of R.sup.7 and R.sup.8 which may be the same or different, is a hydrogen atom or a lower alkyl group) or a group of --N.sup.+ (R.sup.9)(R.sup.10)R.sup.11 (wherein each of R.sup.9, R.sup.10 and R.sup.11 which may be the same or different, is a lower alkyl group), provided that when A is a linear lower alkylene group, R.sup.3 is other than a hydrogen atom; or a pharmaceutically acceptable salt or ester thereof.

    摘要翻译： 下式的化合物：其中R1是氢原子或甲基，R2是氢原子或负电荷，R3是氢原子，卤素原子，羟基，低级烷氧基 低级烷酰氧基，氨基，N-低级烷基氨基，N，N-二低级烷基氨基，低级烷酰基氨基，芳酰氨基，（低级烷基磺酰基）氨基，氨磺酰氨基， 氰基，硝基，-COOR 4（其中R 4是氢原子或低级烷基）或-CON（R 5）R 6（其中R 5和R 6可以相同或不同）的基团 是氢原子或低级烷基，或者R 5和R 6与相邻的氮原子一起形成选自氮丙啶基，氮杂环丁烷基，吡咯烷基，哌啶基，哌嗪基的杂环基 ，4-低级烷基哌嗪基和吗啉代基），A为直链或支链低级亚烷基，X为杂环 -N（R 7）R 8（其中可以相同或不同的R7和R8各自为氢原子或低级烷基）或-N +（R 9）（R 10）R 11（其中每个 R 9，R 10和R 11可以相同或不同，为低级烷基），条件是当A为直链低级亚烷基时，R 3不是氢原子; 或其药学上可接受的盐或酯。