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1.发明授权公开(公告)号：US09504761B2
公开(公告)日：2016-11-29
申请号：US13090732
申请日：2011-04-20
CPC分类号： A61K47/48923 , A61K47/551 , A61K47/6935 , A61K47/6939 , C08B37/003 , C08J3/16 , C08J2305/08 , C08L5/08 , C08L77/04
摘要： A stabilized chitosan-based nanoparticle is provided having a chitosan polymer and a hydrophilic dispersing agent. In the stabilized nanoparticle, chains of the chitosan polymer electrostatically interact with chains of the hydrophilic dispersing agent to form an entangled network between the chitosan polymer and the hydrophilic dispersing agent. The stabilized chitosan-based nanoparticle has optimal particle integrity and stability properties under physiological conditions.
摘要翻译： 提供了具有壳聚糖聚合物和亲水性分散剂的稳定的壳聚糖基纳米颗粒。 在稳定的纳米颗粒中，壳聚糖聚合物的链与亲水分散剂的链静电相互作用以在壳聚糖聚合物和亲水性分散剂之间形成缠结网络。 稳定的壳聚糖基纳米颗粒在生理条件下具有最佳的颗粒完整性和稳定性。
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2.发明申请公开(公告)号：US20120269729A1
公开(公告)日：2012-10-25
申请号：US13090732
申请日：2011-04-20
CPC分类号： A61K47/48923 , A61K47/551 , A61K47/6935 , A61K47/6939 , C08B37/003 , C08J3/16 , C08J2305/08 , C08L5/08 , C08L77/04
摘要： A stabilized chitosan-based nanoparticle is provided having a chitosan polymer and a hydrophilic dispersing agent. In the stabilized nanoparticle, chains of the chitosan polymer electrostatically interact with chains of the hydrophilic dispersing agent to form an entangled network between the chitosan polymer and the hydrophilic dispersing agent. The stabilized chitosan-based nanoparticle has optimal particle integrity and stability properties under physiological conditions.
摘要翻译： 提供了具有壳聚糖聚合物和亲水性分散剂的稳定的壳聚糖基纳米颗粒。 在稳定的纳米颗粒中，壳聚糖聚合物的链与亲水分散剂的链静电相互作用以在壳聚糖聚合物和亲水性分散剂之间形成缠结网络。 稳定的壳聚糖基纳米颗粒在生理条件下具有最佳的颗粒完整性和稳定性。
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3.发明申请ULTRA-SMALL CHITOSAN NANOPARTICLES USEFUL AS BIOIMAGING AGENTS AND METHODS OF MAKING SAME 审中-公开用作生物转化剂的超细小壳聚糖纳米颗粒及其制备方法公开(公告)号：US20110021745A1
公开(公告)日：2011-01-27
申请号：US12667711
申请日：2008-07-07
CPC分类号： A61K49/0093 , A61K9/5161 , A61K47/61 , A61K49/0002 , A61K49/0054 , A61K49/0442 , A61K49/0485 , A61K49/085 , A61K49/126 , A61K49/1824 , B82Y5/00
摘要： A method of making ultra-small chitosan nanoparticles having a size range of approximately 10-20 nm, includes preparing a first microemulsion containing effective amounts of cyclohexane, n-hexanol, chitosan polymer and a nonionic surfactant. A second microemulsion is prepared containing effective amounts of cyclohexane, n-hexanol, tartaric acid, EDC, n-hydroxysuccinimide, and a nonionic surfactant. The method continues by reacting the first and second microemulsions for a time sufficient to form the ultra-small chitosan nanoparticles and recovering the nanoparticles from the reacted microemulsion. The chitosan polymer may be crosslinked and may also be tagged with a fluorescent compound, a radio-opaque compound, a paramagnetic ion, a ligand specific for a predetermined biologic target, a drug, and combinations thereof.
摘要翻译： 制备尺寸范围为约10-20nm的超小型壳聚糖纳米颗粒的方法包括制备含有有效量的环己烷，正己醇，壳聚糖聚合物和非离子表面活性剂的第一微乳液。 制备含有有效量的环己烷，正己醇，酒石酸，EDC，正羟基琥珀酰亚胺和非离子表面活性剂的第二微乳液。 该方法继续通过使第一和第二微乳液反应足以形成超小壳聚糖纳米颗粒并从反应的微乳液回收纳米颗粒的时间。 壳聚糖聚合物可以是交联的，并且还可以用荧光化合物，不透射线的化合物，顺磁离子，对于预定生物靶标特异的配体，药物及其组合进行标记。
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