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公开(公告)号：US20120270940A1
公开(公告)日：2012-10-25
申请号：US13504990
申请日：2010-11-02
申请人： Swantje Behnken , Hans-Martin Dahse , Christian Hertweck , Keishi Ishida , Thorger Lincke , Martin Roth , Florian Kloss
发明人： Swantje Behnken , Hans-Martin Dahse , Christian Hertweck , Keishi Ishida , Thorger Lincke , Martin Roth , Florian Kloss
IPC分类号： C07C327/48 , C07D475/04 , A61K31/166 , A61P35/00 , A61K31/277 , A61K31/197 , A61P31/04 , A61P31/10 , C07K16/00 , A61K31/222
CPC分类号： C07C327/48
摘要： This invention relates to the field of biologically active compounds and specifically to closthioamides, pharmaceutical compositions comprising these compounds, and their use as antibiotic, antifungal, and/or cytotoxic agent.
摘要翻译： 本发明涉及生物活性化合物领域，特别是涉及氯二甲酰胺，包含这些化合物的药物组合物及其作为抗生素，抗真菌剂和/或细胞毒性剂的用途。
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2.发明授权Closthioamides, compositions, and methods for treating bacterial or fungal infections or cancer 有权Closthioamides，组合物和治疗细菌或真菌感染或癌症的方法公开(公告)号：US08673980B2
公开(公告)日：2014-03-18
申请号：US13504990
申请日：2010-11-02
申请人： Swantje Behnken , Hans-Martin Dahse , Christian Hertweck , Keishi Ishida , Thorger Lincke , Martin Roth , Florian Kloss
发明人： Swantje Behnken , Hans-Martin Dahse , Christian Hertweck , Keishi Ishida , Thorger Lincke , Martin Roth , Florian Kloss
IPC分类号： A01N37/18 , A61K31/16 , C07C327/00 , C07C321/00 , C07C323/00 , C07C325/00 , C07C335/00 , C07C381/00 , C07C255/00
CPC分类号： C07C327/48
摘要： This invention relates to the field of biologically active compounds and specifically to closthioamides, pharmaceutical compositions comprising these compounds, and their use as antibiotic, antifungal, and/or cytotoxic agent.
摘要翻译： 本发明涉及生物活性化合物领域，特别是涉及氯二甲酰胺，包含这些化合物的药物组合物及其作为抗生素，抗真菌剂和/或细胞毒性剂的用途。
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3.发明授权Benzopyranobenzothiazinones and their use as fungicides, antibiotics and antitumor agents 有权苯并吡唑并噻嗪酮及其作为杀真菌剂，抗生素和抗肿瘤剂的用途公开(公告)号：US09062077B2
公开(公告)日：2015-06-23
申请号：US14128095
申请日：2012-06-15
申请人： Axel Brakhage , Hans-Martin Dahse , Christian Hertweck , Hans-Wilhelm Nuetzmann , Kirstin Scherlach
发明人： Axel Brakhage , Hans-Martin Dahse , Christian Hertweck , Hans-Wilhelm Nuetzmann , Kirstin Scherlach
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： This invention relates to the field of biologically active compounds and specifically to phaeofungins, of the general formula (I) or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof, pharmaceutical compositions comprising these compounds, methods for the production of the phaeofungins and their use as fungicide, antibiotic as well as antitumor agent.
摘要翻译： 本发明涉及通式（I）的生物活性化合物领域，特别涉及发酵蛋白，或其药学上可接受的盐，溶剂合物，水合物或其药理学上可接受的制剂，包含这些化合物的药物组合物， phaeofungins及其作为杀真菌剂，抗生素以及抗肿瘤剂的用途。
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4.发明申请BENZOPYRANOBENZOTHIAZINONES AND THEIR USE AS FUNGICIDES, ANTIBIOTICS AND ANTITUMOR AGENTS 有权苯并噻唑啉酮及其作为杀真菌剂，抗生素和抗菌剂的用途公开(公告)号：US20140315896A1
公开(公告)日：2014-10-23
申请号：US14128095
申请日：2012-06-15
申请人： Axel Brakhage , Hans-Martin Dahse , Christian Hertweck , Hans-Wilhelm Nuetzmann , Kirstin Scherlach
发明人： Axel Brakhage , Hans-Martin Dahse , Christian Hertweck , Hans-Wilhelm Nuetzmann , Kirstin Scherlach
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： This invention relates to the field of biologically active compounds and specifically to phaeofungins, of the general formula (I) or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof, pharmaceutical compositions comprising these compounds, methods for the production of the phaeofungins and their use as fungicide, antibiotic as well as antitumor agent.
摘要翻译： 本发明涉及通式（I）的生物活性化合物领域，特别涉及赋形剂，其药理学上可接受的盐，溶剂合物，水合物或其药理学上可接受的制剂，包含这些化合物的药物组合物， phaeofungins及其作为杀真菌剂，抗生素以及抗肿瘤剂的用途。
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5.发明申请4-Amino-3-Arylamino-6-Arylpyrazolo[3,4-D) Pyrimidine Derivatives, Methods for their Preparation and their Use as Antiviral Agents 有权4-氨基-3-芳基氨基-6-芳基吡唑并[3,4-D]嘧啶衍生物，其制备方法及其作为抗病毒剂的用途公开(公告)号：US20100010018A1
公开(公告)日：2010-01-14
申请号：US12308729
申请日：2007-06-20
IPC分类号： A61K31/519 , C07D487/04 , A61P31/12
CPC分类号： C07D487/04
摘要： 4-amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidine derivatives of general formula (I), pharmaceutically acceptable salts thereof, method for preparation of the aforesaid compounds and their use as antiviral agents.
摘要翻译： 通式（I）的4-氨基-3-芳氨基-6-芳基吡唑并[3,4-d]嘧啶衍生物，其药学上可接受的盐，上述化合物的制备方法及其作为抗病毒剂的用途。
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公开(公告)号：US20050054609A1
公开(公告)日：2005-03-10
申请号：US10500807
申请日：2003-01-10
申请人： Vera Haack , Thomas Heinze , Michaela Schmidtke , Ute Mollmann , Hans-Martin Dahse , Albert Hartl
发明人： Vera Haack , Thomas Heinze , Michaela Schmidtke , Ute Mollmann , Hans-Martin Dahse , Albert Hartl
IPC分类号： A61K8/72 , A01N33/12 , A01N63/00 , A61K8/73 , A61K31/715 , A61K31/716 , A61K31/717 , A61K31/718 , A61K31/719 , A61K31/721 , A61P31/04 , A61P31/12 , C08B31/12
CPC分类号： A61K31/717 , A61K31/715 , A61K31/716 , A61K31/718 , A61K31/719 , A61K31/721
摘要： The present invention relates to a method of treating infectious diseases, that involves: (a) providing an alpha-glycosidically linked starch polysaccharide derivative; and (b) inhibiting the growth of an infectious disease by administering a composition comprising the alpha-glycosidically linked starch polysaccharide derivative. The alpha-glycosidically linked starch polysaccharide derivative represented by the following general formula I, in which: the alpha-glycosidically linked starch polysaccharide derivative has a degree of quaternary ammonium group substitution of from 0.4 to 2.0; n is 2-4; R1 is selected from the group consisting of C1-4 alkyl, benzyl and benzyl substituted with a member selected from the group consisting of C1-3 alkyl, halogen, alcoxy, carbamoyl, alkoxycarbonyl, cyano, dialkylamino and hydrogen; R2 and R3 are each independently selected from the group consisting of C1-4 alkyl, benzyl and benzyl substituted with a member selected from the group consisting of C1-3 alkyl, halogen, alcoxy, carbamoyl, alkoxycarbonyl, cyano and dialkylamino; and X is an anion selected from the group consisting of halide, hydroxide, sulfate, hydrogen sulfate and carboxylate.
摘要翻译： 本发明涉及一种治疗感染性疾病的方法，其涉及：（a）提供α-糖苷连接的淀粉多糖衍生物; 和（b）通过施用包含α-糖苷连接的淀粉多糖衍生物的组合物来抑制感染性疾病的生长。 由以下通式I表示的α-糖苷连接的淀粉多糖衍生物，其中：α-糖苷连接的淀粉多糖衍生物的季铵基取代度为0.4〜2.0; n为2-4; R1选自C1-4烷基，苄基和被选自C1-3烷基，卤素，烷氧基，氨基甲酰基，烷氧基羰基，氰基，二烷基氨基和氢的成员取代的苄基; R2和R3各自独立地选自C1-4烷基，苄基和被选自C1-3烷基，卤素，烷氧基，氨基甲酰基，烷氧基羰基，氰基和二烷基氨基的成员取代的苄基; X是选自卤化物，氢氧化物，硫酸盐，硫酸氢盐和羧酸盐的阴离子。
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7.发明授权4-amino-3-arylamino-6-arylpyrazolo[3,4-d) pyrimidine derivatives, methods for their preparation and their use as antiviral agents 有权4-氨基-3-芳基氨基-6-芳基吡唑并[3,4-d]嘧啶衍生物，其制备方法及其作为抗病毒剂的用途公开(公告)号：US08962634B2
公开(公告)日：2015-02-24
申请号：US12308729
申请日：2007-06-20
IPC分类号： A61K31/519 , C07D487/00 , C07D487/04
CPC分类号： C07D487/04
摘要： 4-amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidine derivatives of general formula (I), pharmaceutically acceptable salts thereof, method for preparation of the aforesaid compounds and their use as antiviral agents.
摘要翻译： 通式（I）的4-氨基-3-芳氨基-6-芳基吡唑并[3,4-d]嘧啶衍生物，其药学上可接受的盐，上述化合物的制备方法及其作为抗病毒剂的用途。
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公开(公告)号：US07297687B2
公开(公告)日：2007-11-20
申请号：US10500807
申请日：2003-01-10
申请人： Vera Haack , Thomas Heinze , Michaela Schmidtke , Ute Möllmann , Hans-Martin Dahse , Albert Härtl
发明人： Vera Haack , Thomas Heinze , Michaela Schmidtke , Ute Möllmann , Hans-Martin Dahse , Albert Härtl
IPC分类号： A61K31/718 , A61K31/715 , C08B31/00
CPC分类号： A61K31/717 , A61K31/715 , A61K31/716 , A61K31/718 , A61K31/719 , A61K31/721
摘要： The present invention relates to a method of treating infectious diseases, that involves: (a) providing an alpha-glycosidically linked starch polysaccharide derivative; and (b) inhibiting the growth of an infectious disease by administering a composition comprising the alpha-glycosidically linked starch polysaccharide derivative. The alpha-glycosidically linked starch polysaccharide derivative represented by the following general formula I, in which: the alpha-glycosidically linked starch polysaccharide derivative has a degree of quaternary ammonium group substitution of from 0.4 to 2.0; n is 2-4; R1 is selected from the group consisting of C1-4 alkyl, benzyl and benzyl substituted with a member selected from the group consisting of C1-3 alkyl, halogen, alcoxy, carbamoyl, alkoxycarbonyl, cyano, dialkylamino and hydrogen; R2 and R3 are each independently selected from the group consisting of C1-4 alkyl, benzyl and benzyl substituted with a member selected from the group consisting of C1-3 alkyl, halogen, alcoxy, carbamoyl, alkoxycarbonyl, cyano and dialkylamino; and X is an anion selected from the group consisting of halide, hydroxide, sulfate, hydrogen sulfate and carboxylate.
摘要翻译： 本发明涉及一种治疗感染性疾病的方法，其涉及：（a）提供α-糖苷连接的淀粉多糖衍生物; 和（b）通过施用包含α-糖苷连接的淀粉多糖衍生物的组合物来抑制感染性疾病的生长。 由以下通式I表示的α-糖苷连接的淀粉多糖衍生物，其中：α-糖苷连接的淀粉多糖衍生物的季铵基取代度为0.4〜2.0; n为2-4; R 1选自C 1-4烷基，苄基和被选自C 1-3烷基的成员取代的苄基， 烷基，卤素，烷氧基，氨基甲酰基，烷氧基羰基，氰基，二烷基氨基和氢; R 2和R 3各自独立地选自C 1-4烷基，苄基和被选自以下的成员取代的苄基： 由C 1-3烷基，卤素，烷氧基，氨基甲酰基，烷氧基羰基，氰基和二烷基氨基组成的组; X是选自卤化物，氢氧化物，硫酸盐，硫酸氢盐和羧酸盐的阴离子。
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