公开(公告)号：US20140140655A1

公开(公告)日：2014-05-22

申请号：US14165554

申请日：2014-01-27

申请人： Swapnajit Chakravarty ,  Amir Hosseini ,  Ray T. Chen

发明人： Swapnajit Chakravarty ,  Amir Hosseini ,  Ray T. Chen

IPC分类号： G02B6/12

CPC分类号： G01N21/253 ,  B82Y20/00 ,  G01N21/7746 ,  G01N33/54373 ,  G01N2021/7789 ,  G02B6/1225 ,  G02B6/124 ,  G02B6/2813 ,  G02B6/30 ,  G02B6/34 ,  G02B2006/12154

摘要： Systems and methods for chip-integrated label-free detection and absorption spectroscopy with high throughput, sensitivity, and specificity are disclosed. The invention comprises packaged chips for multiplexing photonic crystal microcavity waveguide and photonic crystal slot waveguide devices. The packaged chips comprise crossing waveguides to prevent leakage of fluids from the microfluidic channels from the trenches or voids around the light guiding waveguides. Other embodiments are described and claimed.

摘要翻译： 公开了具有高通量，灵敏度和特异性的芯片集成的无标签检测和吸收光谱的系统和方法。 本发明包括用于复用光子晶体微腔波导和光子晶体槽波导器件的封装芯片。 封装的芯片包括交叉波导，以防止流体从微流体通道从导光波导周围的沟槽或空隙泄漏。 描述和要求保护其他实施例。

公开(公告)号：US20140084147A1

公开(公告)日：2014-03-27

申请号：US14089759

申请日：2013-11-26

申请人： Swapnajit Chakravarty ,  Ray T. Chen

发明人： Swapnajit Chakravarty ,  Ray T. Chen

IPC分类号： G01N21/35 ,  G01N21/33

CPC分类号： G01N21/3504 ,  B82Y20/00 ,  G01N21/33 ,  G02B6/1225 ,  G02B6/1228

摘要： Methods and systems for a label-free on-chip optical absorption spectrometer consisting of a photonic crystal slot waveguide are disclosed. The invention comprises an on-chip integrated optical absorption spectroscopy device that combines the slow light effect in photonic crystal waveguide and optical field enhancement in a slot waveguide and enables detection and identification of multiple analytes to be performed simultaneously using optical absorption techniques leading to a device for chemical and biological sensing, trace detection, and identification via unique analyte absorption spectral signatures. Other embodiments are described and claimed.

摘要翻译： 公开了一种由光子晶体槽波导组成的无标签片上光吸收光谱仪的方法和系统。 本发明包括片内集成光吸收光谱装置，其结合光子晶体波导中的慢光效应和时隙波导中的光场增强，并且能够使用导致器件的光吸收技术同时执行多个分析物的检测和识别 用于化学和生物感测，痕量检测和通过独特的分析物吸收光谱特征识别。 描述和要求保护其他实施例。

公开(公告)号：US20120328233A1

公开(公告)日：2012-12-27

申请号：US13607794

申请日：2012-09-09

申请人： Swapnajit Chakravarty ,  Ray T. Chen

发明人： Swapnajit Chakravarty ,  Ray T. Chen

IPC分类号： G01N21/25

CPC分类号： G01N21/3504 ,  B82Y20/00 ,  G01N21/33 ,  G02B6/1225 ,  G02B6/1228

摘要： Methods and systems for a label-free on-chip optical absorption spectrometer consisting of a photonic crystal slot waveguide are disclosed. The invention comprises an on-chip integrated optical absorption spectroscopy device that combines the slow light effect in photonic crystal waveguide and optical field enhancement in a slot waveguide and enables detection and identification of multiple analytes to be performed simultaneously using optical absorption techniques leading to a device for chemical and biological sensing, trace detection, and identification via unique analyte absorption spectral signatures. Other embodiments are described and claimed.

摘要翻译： 公开了一种由光子晶体槽波导组成的无标签片上光吸收光谱仪的方法和系统。 本发明包括片内集成光吸收光谱装置，其结合光子晶体波导中的慢光效应和时隙波导中的光场增强，并且能够使用导致器件的光吸收技术同时执行多个分析物的检测和识别 用于化学和生物感测，痕量检测和通过独特的分析物吸收光谱特征识别。 描述和要求保护其他实施例。

公开(公告)号：US20140378328A1

公开(公告)日：2014-12-25

申请号：US14308671

申请日：2014-06-18

申请人： Swapnajit Chakravarty ,  Yunbo Guo ,  Ray T. Chen

发明人： Swapnajit Chakravarty ,  Yunbo Guo ,  Ray T. Chen

IPC分类号： G01N21/27 ,  B01J19/00

CPC分类号： B01J19/0046 ,  G01N21/7743

摘要： Methods and systems for highly-sensitive label-free multiple analyte sensing, biosensing, and diagnostic assay are disclosed. The systems comprise an on-chip integrated two-dimensional photonic crystal sensor chip. The invention provides modulation methods, wavelength modulation and intensity modulation, to monitor the resonance mode shift of the photonic crystal microarray device and further provides methods and systems that enable detection and identification of multiple species to be performed simultaneously with one two-dimensional photonic crystal sensor chip device for high throughput chemical sensing, biosensing, and medical diagnostics. Other embodiments are described and claimed.

摘要翻译： 公开了用于高灵敏度无标记多分析物感测，生物传感和诊断测定的方法和系统。 该系统包括片上集成的二维光子晶体传感器芯片。 本发明提供调制方法，波长调制和强度调制，以监测光子晶体微阵列装置的共振模式偏移，并进一步提供方法和系统，使得能够与一个二维光子晶体传感器同时进行多个物种的检测和识别 用于高通量化学感测，生物传感和医疗诊断的芯片器件。 描述和要求保护其他实施例。

公开(公告)号：US20140141999A1

公开(公告)日：2014-05-22

申请号：US14163137

申请日：2014-01-24

申请人： Swapnajit Chakravarty ,  Amir Hosseini ,  Ray T. Chen

发明人： Swapnajit Chakravarty ,  Amir Hosseini ,  Ray T. Chen

IPC分类号： G01N33/543 ,  G01N21/25

CPC分类号： G01N33/54373 ,  G01N21/253 ,  G01N21/255 ,  G01N21/7746 ,  G01N2021/7789 ,  G02B6/1225

摘要： Systems and methods for chip-integrated label-free detection and absorption spectroscopy with high throughput, sensitivity, and specificity are disclosed. The invention comprises packaged chips for multiplexing photonic crystal waveguide and photonic crystal slot waveguide devices. Other embodiments are described and claimed.

摘要翻译： 公开了具有高通量，灵敏度和特异性的芯片集成的无标签检测和吸收光谱的系统和方法。 本发明包括用于复用光子晶体波导和光子晶体槽波导器件的封装芯片。 描述和要求保护其他实施例。

公开(公告)号：US08617471B2

公开(公告)日：2013-12-31

申请号：US13607794

申请日：2012-09-09

申请人： Swapnajit Chakravarty ,  Ray T. Chen

发明人： Swapnajit Chakravarty ,  Ray T. Chen

IPC分类号： G01N21/00

CPC分类号： G01N21/3504 ,  B82Y20/00 ,  G01N21/33 ,  G02B6/1225 ,  G02B6/1228

摘要： Methods and systems for a label-free on-chip optical absorption spectrometer consisting of a photonic crystal slot waveguide are disclosed. The invention comprises an on-chip integrated optical absorption spectroscopy device that combines the slow light effect in photonic crystal waveguide and optical field enhancement in a slot waveguide and enables detection and identification of multiple analytes to be performed simultaneously using optical absorption techniques leading to a device for chemical and biological sensing, trace detection, and identification via unique analyte absorption spectral signatures. Other embodiments are described and claimed.

摘要翻译： 公开了一种由光子晶体槽波导组成的无标签片上光吸收光谱仪的方法和系统。 本发明包括片内集成光吸收光谱装置，其结合光子晶体波导中的慢光效应和时隙波导中的光场增强，并且能够使用导致器件的光吸收技术同时执行多个分析物的检测和识别 用于化学和生物感测，痕量检测和通过独特的分析物吸收光谱特征识别。 描述和要求保护其他实施例。

公开(公告)号：US09157850B2

公开(公告)日：2015-10-13

申请号：US14089759

申请日：2013-11-26

申请人： Swapnajit Chakravarty ,  Ray T. Chen

发明人： Swapnajit Chakravarty ,  Ray T. Chen

IPC分类号： G01N21/00 ,  G01N21/3504 ,  B82Y20/00 ,  G02B6/122 ,  G01N21/33

CPC分类号： G01N21/3504 ,  B82Y20/00 ,  G01N21/33 ,  G02B6/1225 ,  G02B6/1228

摘要： Methods and systems for a label-free on-chip optical absorption spectrometer consisting of a photonic crystal slot waveguide are disclosed. The invention comprises an on-chip integrated optical absorption spectroscopy device that combines the slow light effect in photonic crystal waveguide and optical field enhancement in a slot waveguide and enables detection and identification of multiple analytes to be performed simultaneously using optical absorption techniques leading to a device for chemical and biological sensing, trace detection, and identification via unique analyte absorption spectral signatures. Other embodiments are described and claimed.

摘要翻译： 公开了一种由光子晶体槽波导组成的无标签片上光吸收光谱仪的方法和系统。 本发明包括片内集成光吸收光谱装置，其结合光子晶体波导中的慢光效应和时隙波导中的光场增强，并且能够使用导致器件的光吸收技术同时执行多个分析物的检测和识别 用于化学和生物感测，痕量检测和通过独特的分析物吸收光谱特征识别。 描述和要求保护其他实施例。

公开(公告)号：US08623284B2

公开(公告)日：2014-01-07

申请号：US13607793

申请日：2012-09-09

申请人： Swapnajit Chakravarty ,  Ray T. Chen

发明人： Swapnajit Chakravarty ,  Ray T. Chen

IPC分类号： G01N21/00

CPC分类号： B01J19/0046 ,  G01N21/7746 ,  G01N33/54373 ,  G01N2021/7789 ,  G02B6/1225

摘要： Methods and systems for label-free multiple analyte sensing, biosensing and diagnostic assay chips consisting of an array of photonic crystal microcavities along a single photonic crystal waveguide are disclosed. The invention comprises an on-chip integrated microarray device that enables detection and identification of multiple species to be performed simultaneously using optical techniques leading to a high throughput device for chemical sensing, biosensing and medical diagnostics. Other embodiments are described and claimed.

摘要翻译： 公开了用于无标记的多分析物感测，生物传感和诊断测定芯片的方法和系统，其由沿着单个光子晶体波导的光子晶体微腔阵列组成。 本发明包括片上集成微阵列装置，其能够使用导致用于化学感测，生物传感和医学诊断的高通量装置的光学技术同时进行多种物种的检测和鉴定。 描述和要求保护其他实施例。

公开(公告)号：US08580200B2

公开(公告)日：2013-11-12

申请号：US13607791

申请日：2012-09-09

申请人： Swapnajit Chakravarty ,  Ray T. Chen

发明人： Swapnajit Chakravarty ,  Ray T. Chen

IPC分类号： G01N21/00

CPC分类号： G01N33/54373 ,  G01N21/253

摘要： Methods and systems for label-free multiple analyte sensing, biosensing and diagnostic assay chips consisting of an array of photonic crystal microcavities along a single photonic crystal waveguide are disclosed. The invention comprises an on-chip integrated microarray device that enables detection and identification of multiple species to be performed simultaneously using optical techniques leading to a high throughput device for chemical sensing, biosensing and medical diagnostics. Other embodiments are described and claimed.

摘要翻译： 公开了用于无标记的多分析物感测，生物传感和诊断测定芯片的方法和系统，其由沿着单个光子晶体波导的光子晶体微腔阵列组成。 本发明包括片上集成微阵列装置，其能够使用导致用于化学感测，生物传感和医学诊断的高通量装置的光学技术同时进行多种物种的检测和鉴定。 描述和要求保护其他实施例。

公开(公告)号：US20130005605A1

公开(公告)日：2013-01-03

申请号：US13607793

申请日：2012-09-09

申请人： Swapnajit Chakravarty ,  Ray T. Chen

发明人： Swapnajit Chakravarty ,  Ray T. Chen

IPC分类号： C40B30/04 ,  C40B60/12

CPC分类号： B01J19/0046 ,  G01N21/7746 ,  G01N33/54373 ,  G01N2021/7789 ,  G02B6/1225

摘要： Methods and systems for label-free multiple analyte sensing, biosensing and diagnostic assay chips consisting of an array of photonic crystal microcavities along a single photonic crystal waveguide are disclosed. The invention comprises an on-chip integrated microarray device that enables detection and identification of multiple species to be performed simultaneously using optical techniques leading to a high throughput device for chemical sensing, biosensing and medical diagnostics. Other embodiments are described and claimed.

摘要翻译： 公开了用于无标记的多分析物感测，生物传感和诊断测定芯片的方法和系统，其由沿着单个光子晶体波导的光子晶体微腔阵列组成。 本发明包括片上集成微阵列装置，其能够使用导致用于化学感测，生物传感和医学诊断的高通量装置的光学技术同时进行多种物种的检测和鉴定。 描述和要求保护其他实施例。