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公开(公告)号：US08191501B2
公开(公告)日：2012-06-05
申请号：US12616651
申请日：2009-11-11
申请人： Syed F. A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
发明人： Syed F. A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
IPC分类号： B05B5/00
CPC分类号： B05D1/32 , B05B12/20 , B05B13/0442 , B05D1/02 , Y10T428/13
摘要： A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article.
摘要翻译： 用于在涂覆过程中遮蔽支架的掩模可以包括掩模体，其具有由掩模体遮蔽的支架图案的负图案或近似负图案。 用于选择性地涂覆医疗用品的预定部分的设备可以包括涂料组合物的分配器，掩模，用于在面罩和医疗制品之间产生相对运动的装置。
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公开(公告)号：US07638156B1
公开(公告)日：2009-12-29
申请号：US11312149
申请日：2005-12-19
申请人： Syed F. A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
发明人： Syed F. A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
IPC分类号： A61L33/00
CPC分类号： B05D1/32 , B05B12/20 , B05B13/0442 , B05D1/02 , Y10T428/13
摘要： Masking apparatus and methods of masking a medical article, such as stent, for selective application of a coating composition on the article are disclosed.
摘要翻译： 公开了掩模设备和掩蔽诸如支架之类的医疗用品的选择性施用涂料组合物的方法。
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公开(公告)号：US20100055295A1
公开(公告)日：2010-03-04
申请号：US12616651
申请日：2009-11-11
申请人： Syed F.A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
发明人： Syed F.A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
CPC分类号： B05D1/32 , B05B12/20 , B05B13/0442 , B05D1/02 , Y10T428/13
摘要： A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article.
摘要翻译： 用于在涂覆过程中遮蔽支架的掩模可以包括掩模体，其具有由掩模体遮蔽的支架图案的负图案或近似负图案。 用于选择性地涂覆医疗用品的预定部分的设备可以包括涂料组合物的分配器，掩模，用于在面罩和医疗制品之间产生相对运动的装置。
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公开(公告)号：US20080305141A1
公开(公告)日：2008-12-11
申请号：US11472760
申请日：2006-06-21
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2300/608 , A61L2420/02
摘要： Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.
摘要翻译： 公开了用于控制活性剂从包含聚合物基质和一种或多种活性剂的医疗装置的涂层的形态和释放速率的方法。 所述方法包括将湿或干涂层暴露于冻融循环。 涂层可用于控制递送活性剂或活性剂的组合。
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公开(公告)号：US08246973B2
公开(公告)日：2012-08-21
申请号：US11472760
申请日：2006-06-21
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2300/608 , A61L2420/02
摘要： Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.
摘要翻译： 公开了用于控制活性剂从包含聚合物基质和一种或多种活性剂的医疗装置的涂层的形态和释放速率的方法。 所述方法包括将湿或干涂层暴露于冻融循环。 涂层可用于控制递送活性剂或活性剂的组合。
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6.发明授权公开(公告)号：US08435550B2
公开(公告)日：2013-05-07
申请号：US12191209
申请日：2008-08-13
申请人： Jin Cheng , Stephen Dugan , Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Christopher Feezor , Gene Park , Wouter Roorda , Syed F. A. Hossainy
发明人： Jin Cheng , Stephen Dugan , Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Christopher Feezor , Gene Park , Wouter Roorda , Syed F. A. Hossainy
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0067 , A61F2250/0068 , A61K31/4745 , A61K31/56 , A61K31/573 , A61L31/10 , A61L31/148 , A61L2300/222 , A61L2300/416 , A61L2300/45 , A61K2300/00
摘要： A drug-delivery system is provided including at least 100 μg of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 μg, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).
摘要翻译： 提供了一种药物递送系统，其包括至少100杯依维莫司和氯倍他索，使得依维莫司与氯倍他索的比例至少为10：1（w / w），依维莫司的重量比为至少10倍 氯倍他索 该系统可以是支架。 还提供了治疗血管的再狭窄或易损斑块的方法，所述方法包括向患者局部施用选自雷帕霉素（西罗莫司），Biolimus A9，deforolimus，AP23572，他克莫司，替西罗莫司，吡美莫司， 40-（2-羟基）乙基雷帕霉素（依维莫司），40-O-（3-羟基）丙基雷帕霉素，40-O- [2-（2-羟基）乙氧基]乙基雷帕霉素，40- O-四唑基雷帕霉素和40-表 - （N1-四唑基）雷帕霉素，并且对患者局部施用由氯倍他索组成的第二药物，其中局部施用的第一药物的最小量为100杯，其中 第二种药物的第一种药物例如为10：1〜100：1（w / w）。
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公开(公告)号：US08173199B2
公开(公告)日：2012-05-08
申请号：US11527893
申请日：2006-09-26
申请人： Syed F. A. Hossainy , Gordon Stewart , Mark A. Williams , Jeff Royal , Paul M. Consigny , Dorrie M. Happ , Kurt Scheinpflug , Ty Hu
发明人： Syed F. A. Hossainy , Gordon Stewart , Mark A. Williams , Jeff Royal , Paul M. Consigny , Dorrie M. Happ , Kurt Scheinpflug , Ty Hu
CPC分类号： A61F2/844 , A61F2250/0067 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606
摘要： A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.
摘要翻译： 公开了一种用于降低活性剂从可植入装置（例如支架）的释放速率的方法和涂层。
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8.发明授权Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin 有权用40-O-（2-羟基）乙基雷帕霉素的释放聚合物涂覆支架的方法公开(公告)号：US08961588B2
公开(公告)日：2015-02-24
申请号：US11527971
申请日：2006-09-26
申请人： Syed F. A. Hossainy , Gordon Stewart , Mark A. Williams , Jeff Royal , Paul M. Consigny , Dorie M. Happ , Kurt Scheinpflug , Ty Hu
发明人： Syed F. A. Hossainy , Gordon Stewart , Mark A. Williams , Jeff Royal , Paul M. Consigny , Dorie M. Happ , Kurt Scheinpflug , Ty Hu
CPC分类号： A61F2/844 , A61F2250/0067 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606
摘要： A method of coating a stent is presented such that less than 50% of the total amount of 40-O-(2-hydroxyl)ethyl-rapamycin, or an analog or derivative thereof, is released in vivo in a 24 hour period, wherein the method comprises exposing the coating to sufficient temperature to modify the structure of the polymer.
摘要翻译： 提出了一种涂覆支架的方法，使得在24小时内体内释放40-O-（2-羟基）乙基雷帕霉素或其类似物或衍生物的总量的少于50％，其中 该方法包括将涂层暴露于足够的温度以改变聚合物的结构。
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9.发明授权Poly(ester amides) for the control of agent-release from polymeric compositions 有权用于控制聚合物组合物释放试剂的聚（酯酰胺）公开(公告)号：US08815274B2
公开(公告)日：2014-08-26
申请号：US12478693
申请日：2009-06-04
申请人： Jessica R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F. A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
发明人： Jessica R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F. A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
IPC分类号： A61F13/00
CPC分类号： A61L31/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , C08L77/12
摘要： The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
摘要翻译： 本发明通常包括医疗制品，例如包含试剂或试剂组合的医疗装置或涂层，其中所述试剂分布在整个聚合物基质中。 聚合物基质包含试剂和聚（酯酰胺），该聚（酯酰胺）具有预先设计以提供来自医药制品的试剂组合的预定释放速率的设计。
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公开(公告)号：US07396539B1
公开(公告)日：2008-07-08
申请号：US10177154
申请日：2002-06-21
申请人： Syed F A. Hossainy , Gordon Stewart
发明人： Syed F A. Hossainy , Gordon Stewart
IPC分类号： A61F2/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2420/08 , C08L33/10
摘要： Coatings and methods of forming coatings for implantable medical devices, such as stents, are described. The coatings are used for the sustained release of a therapeutic agent or drug.
摘要翻译： 描述了用于可植入医疗装置（例如支架）的成膜涂层和方法。 涂层用于治疗剂或药物的持续释放。
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