公开(公告)号：US20180135029A1

公开(公告)日：2018-05-17

申请号：US15514120

申请日：2015-09-27

Applicant: Symrise AG

Inventor： Ludger Wessjohann ,  Anne-Kathrin Bauer ,  Jakob Ley ,  Torsten Geissier ,  Katrin Geissler

IPC: C12N9/10 ,  C12N9/02 ,  C12N15/64 ,  C12P17/06

CPC classification number: C12N9/1007 ,  C12N9/0071 ,  C12N15/64 ,  C12P17/06 ,  C12Y114/14001 ,  C12Y201/01

Abstract: A method is proposed for producing flavonoids, comprising the steps: (a) providing of a transgenic microorganism, containing (i) a first nucleic acid section (A), comprising or consisting of a gene coding for a CYP450 oxidase, (ii) a second nucleic acid section (B), comprising or consisting of a gene coding for a plant O-methyltransferase, and (b) adding of one or more flavanones to the transgenic microorganism, (c) the conversion of the substrate flavanones by the transgenic microorganism to the corresponding flavonoids, and optionally (d) isolating and purifying of the final products.