公开(公告)号：US20030218467A1

公开(公告)日：2003-11-27

申请号：US10155207

申请日：2002-05-24

Applicant: Symyx Technologies, Inc.

Inventor： Eric D. Carlson ,  Oleg Kolosov ,  Leonid Matsiev ,  Laura T. Mazzola ,  Mikhail Spitkovsky ,  John Gallipeo

IPC: G01R027/04 ,  G01R027/32

CPC classification number: G01N29/036 ,  B01J2219/00689 ,  B01J2219/00707 ,  G01G3/13 ,  G01N5/045 ,  G01N33/15 ,  G01N2291/0257

Abstract: A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate monitoring the response of a resonator holding a sample and correlating the response with mass change in the samples.

Abstract translation: 用于测量小样品量的质量的方法和装置。 该方法和装置特别适于提供固体材料的微量天平测量作为组合研究程序的一部分。 该方法和装置考虑监测保持样品的谐振器的响应并将响应与样本中的质量变化相关联。

公开(公告)号：US20030108879A1

公开(公告)日：2003-06-12

申请号：US10043394

申请日：2002-01-10

Applicant: Symyx Technologies, Inc.

Inventor： Gerrit Klaerner ,  Didier Benoit ,  Dominique Charmot ,  Srinivas Nomula ,  Marcelo Eduardo Piotti ,  Laura T. Mazzola

IPC: C12Q001/68 ,  C12M001/34

CPC classification number: G01N33/54353 ,  C08F293/005

Abstract: Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

Abstract translation: 用于确定生物样品中生物分子的存在和浓度的传感器以聚合物刷的形式提供，所述聚合物刷包括具有用疏水性聚合物链段修饰的表面的基底，其附着有水分散性或水溶性聚合物链段 具有结合探针的官能团。 合成这种传感器的方法优选包括使用受控的自由基聚合技术，其允许可控结构聚合物改性底物的表面，以及使用具有在探针附着之前不需要活化的官能团的单体。 以这种方式，从表面去除聚合物链中的官能团，这允许溶液化学更具体地再现，具有固体结合探针的优点。