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公开(公告)号：US11821109B2
公开(公告)日：2023-11-21
申请号：US15922292
申请日：2018-03-15
IPC分类号： C12Q1/68 , G01N33/53 , C40B40/08 , B01J19/00 , B01L3/00 , B82Y10/00 , B82Y30/00 , C07K1/04 , C40B40/10 , B01F25/433 , B01F33/302 , B01F33/3031 , B01J13/02 , C40B40/06 , C40B50/08 , G01N35/10 , B01F23/41 , C12N15/10
CPC分类号： C40B40/08 , B01F25/433 , B01F25/4331 , B01F25/4338 , B01F33/3021 , B01F33/3031 , B01J13/025 , B01J19/0046 , B01L3/5025 , B01L3/5027 , B01L3/502761 , B01L3/502784 , B82Y10/00 , B82Y30/00 , C07K1/047 , C40B40/10 , H05K999/99 , B01F23/41 , B01J2219/005 , B01J2219/0086 , B01J2219/00497 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01J2219/00853 , B01J2219/00889 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2200/0673 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , C12N15/1096 , C12Q2563/159 , C12Q2600/16 , C40B40/06 , C40B50/08 , G01N2035/1034
摘要： The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.
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公开(公告)号：US09839890B2
公开(公告)日：2017-12-12
申请号：US11665099
申请日：2005-10-12
申请人： Andrew Griffiths , David Weitz , Darren Link , Keunho Ahn , Jerome Bibette
发明人： Andrew Griffiths , David Weitz , Darren Link , Keunho Ahn , Jerome Bibette
IPC分类号： C40B30/00 , C40B50/00 , B01F13/00 , B01F5/06 , B01J19/00 , B01L3/00 , B82Y10/00 , B82Y30/00 , C07K1/04 , C40B30/04 , B01F3/08 , C40B40/06 , C40B40/10 , C40B50/08 , G01N35/10
CPC分类号： B01F13/0071 , B01F3/0807 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0076 , B01J19/0046 , B01J2219/00497 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01J2219/00853 , B01J2219/0086 , B01J2219/00889 , B01L3/5025 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L2200/0605 , B01L2200/0673 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , B82Y10/00 , B82Y30/00 , C07K1/047 , C40B40/06 , C40B40/10 , C40B50/08 , G01N2035/1034
摘要： The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control, The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.
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公开(公告)号：US09310291B2
公开(公告)日：2016-04-12
申请号：US10892743
申请日：2004-07-16
申请人： Torsten Schulz , Eugen Ermantraut , Ralf Ehricht , Klaus-Peter Möbius , Gerd Wagner , Joachim Fischer , Thomas Ellinger
发明人： Torsten Schulz , Eugen Ermantraut , Ralf Ehricht , Klaus-Peter Möbius , Gerd Wagner , Joachim Fischer , Thomas Ellinger
CPC分类号： C12Q1/6837 , B01J2219/00283 , B01J2219/00529 , B01J2219/0054 , B01J2219/00585 , B01J2219/00596 , B01J2219/00707 , B01J2219/00722 , B01L3/50 , B01L3/5082 , B01L7/52 , B01L2300/0636 , B01L2300/0851 , C40B40/06 , C40B60/14 , C40B70/00 , G01N21/253 , G01N33/54366 , C12Q2547/101
摘要： The invention relates to a reaction vessel, a device and a method for detecting specific interactions between molecular target and probe molecules. The present invention especially relates to a reaction vessel which has a shape and size typical of a laboratory reaction vessel and in which a supporting element with probe molecules immobilized thereon on predetermined regions is arranged on its base surfaces.
摘要翻译： 本发明涉及一种用于检测分子靶和探针分子之间的特异性相互作用的反应容器，装置和方法。 本发明特别涉及一种反应容器，其具有典型的实验室反应容器的形状和尺寸，其中在预定区域上固定有探针分子的支撑元件布置在其基面上。
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公开(公告)号：US09304084B2
公开(公告)日：2016-04-05
申请号：US14608350
申请日：2015-01-29
发明人： Stephen Empedocles , Andrew Watson , Jian Jin
IPC分类号： G01N21/75 , G01N21/64 , G01N21/27 , B01L3/00 , G01N21/25 , G01N33/543 , G01N35/00 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N15/00 , G01N15/14
CPC分类号： G01N21/272 , B01J2219/00317 , B01J2219/00432 , B01J2219/005 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00743 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L3/545 , B01L2200/0668 , B01L2300/021 , B01L2300/0819 , B01L2300/0829 , B01L2400/0454 , B01L2400/0457 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/25 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/6489 , G01N33/54373 , G01N2015/0092 , G01N2015/1472 , G01N2015/1497 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00742 , G01N2035/00752 , G01N2201/04 , G01N2201/06113 , G01N2201/12
摘要： Devices, systems, kits, and methods for detecting and/or identifying a plurality of spectrally labeled bodies well-suited for performing multiplexed assays. By spectrally labeling the beads with materials which generate identifiable spectra, a plurality of beads may be identified within the fluid. Reading of the beads is facilitated by restraining the beads in arrays, and/or using a focused laser.
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5.发明授权Device and method for testing catalysts with variable process pressure adjustment 有权用于测试具有可变过程压力调节的催化剂的装置和方法公开(公告)号：US09228985B2
公开(公告)日：2016-01-05
申请号：US13880821
申请日：2011-10-17
CPC分类号： G01N31/10 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00389 , B01J2219/00391 , B01J2219/00423 , B01J2219/00477 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00601 , B01J2219/00689 , B01J2219/00707 , B01J2219/00747 , B01J2219/00792 , B01J2219/00835 , B01J2219/00869 , B01J2219/00873 , B01J2219/00963 , B01J2219/00986
摘要： The present invention relates to a catalysis apparatus for testing catalysts with variable process pressure adjustment over a pressure range from 0.01 millibar to 300 bar. The apparatus preferably has a plurality of reaction chambers (101, 102, . . . ) arranged in parallel, the reaction chamber outlet-side lines (211, 212, . . . ) of which are divided into two groups of sub-lines. One group of main lines (411, 412, . . . ) is operatively connected to a regulating valve (61), which is common to all of the main lines, and to an exhaust-air line (62), and the second group of secondary lines (311, 312, 313, . . . ) and switching valves (321, 322, . . . ) is operatively connected to an analysis unit (34). It is preferable for reaction chamber outlet-side lines (201, 202, . . . ) to be equipped in each case with a separate line for regulating fluid supply (211, 212, . . . ). In a preferred embodiment, the connecting points of the reaction chamber outlet-side lines (201, 202, . . . ) to the respective main lines (411, 412, . . . ) and secondary lines (311, 312, . . . ) have in each case one mixing vessel (301, 302, . . . ).
摘要翻译： 本发明涉及一种用于在0.01毫巴至300巴的压力范围内测试具有可变过程压力调节的催化剂的催化装置。 该装置优选地具有并排布置的多个反应室（101,102 ...），反应室出口侧管线（211,212 ...）被分成两组子管线。 一组主线路（411,412 ...）可操作地连接到所有主线路和排气管线（62）共同的调节阀（61），并且第二组 的二次管线（311,312,313 ......）和切换阀（321,322 ...）可操作地连接到分析单元（34）。 反应室出口侧管线（201,202 ...）最好在各种情况下配备一条用于调节流体供应（211,212 ...）的单独管线。 在一个优选实施例中，反应室出口侧线（201,202 ...）到相应主线（411,412 ...）和次级线（311,312 ...）的连接点。 ）在每种情况下都具有一个混合容器（301,302 ......）。
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公开(公告)号：US09228948B2
公开(公告)日：2016-01-05
申请号：US14700248
申请日：2015-04-30
发明人： Stephen Empedocles , Andrew Watson , Jian Jin
IPC分类号： G01N21/25 , G01N21/27 , G01N21/64 , B01L3/00 , G01N33/543 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N15/00 , G01N15/14 , G01N35/00
CPC分类号： G01N21/272 , B01J2219/00317 , B01J2219/00432 , B01J2219/005 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00743 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L3/545 , B01L2200/0668 , B01L2300/021 , B01L2300/0819 , B01L2300/0829 , B01L2400/0454 , B01L2400/0457 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/25 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/6489 , G01N33/54373 , G01N2015/0092 , G01N2015/1472 , G01N2015/1497 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00742 , G01N2035/00752 , G01N2201/04 , G01N2201/06113 , G01N2201/12
摘要： Devices, systems, kits, and methods for detecting and/or identifying a plurality of spectrally labeled bodies well-suited for performing multiplexed assays. By spectrally labeling the beads with materials which generate identifiable spectra, a plurality of beads may be identified within the fluid. Reading of the beads is facilitated by restraining the beads in arrays, and/or using a focused laser.
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公开(公告)号：US20150355079A1
公开(公告)日：2015-12-10
申请号：US14827545
申请日：2015-08-17
发明人： Stephen Empedocles , Andrew Watson , Jian Jin
CPC分类号： G01N21/272 , B01J2219/00317 , B01J2219/00432 , B01J2219/005 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00743 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L3/545 , B01L2200/0668 , B01L2300/021 , B01L2300/0819 , B01L2300/0829 , B01L2400/0454 , B01L2400/0457 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/25 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/6489 , G01N33/54373 , G01N2015/0092 , G01N2015/1472 , G01N2015/1497 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00742 , G01N2035/00752 , G01N2201/04 , G01N2201/06113 , G01N2201/12
摘要： Devices, systems, kits, and methods for detecting and/or identifying a plurality of spectrally labeled bodies well-suited for performing multiplexed assays. By spectrally labeling the beads with materials which generate identifiable spectra, a plurality of beads may be identified within the fluid. Reading of the beads is facilitated by restraining the beads in arrays, and/or using a focused laser.
摘要翻译： 用于检测和/或识别非常适合于进行多重测定的多个光谱标记物质的装置，系统，试剂盒和方法。 通过用产生可识别光谱的材料对珠粒进行光谱标记，可以在流体内识别多个珠粒。 通过将阵列中的珠抑制和/或使用聚焦激光来促进珠的读取。
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公开(公告)号：US20140347953A1
公开(公告)日：2014-11-27
申请号：US14262424
申请日：2014-04-25
CPC分类号： C30B7/14 , B01F5/00 , B01F13/0093 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/502738 , B01L3/502746 , B01L3/502769 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B81B1/00 , C30B29/02 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0017 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0086 , Y10T117/1004 , Y10T117/1008 , Y10T117/1012 , Y10T137/0318 , Y10T137/0324 , Y10T137/2224 , Y10T436/25
摘要： A static fluid and a second fluid are placed into contact along a microfluidic free interface and allowed to mix by diffusion without convective flow across the interface. In accordance with one embodiment of the present invention, the fluids are static and initially positioned on either side of a closed valve structure in a microfluidic channel having a width that is tightly constrained in at least one dimension. The valve is then opened, and no-slip layers at the sides of the microfluidic channel suppress convective mixing between the two fluids along the resulting interface. Applications for microfluidic free interfaces in accordance with embodiments of the present invention include, but are not limited to, protein crystallization studies, protein solubility studies, determination of properties of fluidics systems, and a variety of biological assays such as diffusive immunoassays, substrate turnover assays, and competitive binding assays.
摘要翻译： 将静态流体和第二流体沿微流体界面放置接触，并允许通过扩散混合而不对流流过该界面。 根据本发明的一个实施例，流体是静态的，并且最初位于微流体通道中的封闭阀结构的任一侧上，该微流体通道的宽度被紧紧地约束在至少一个维度上。 然后打开阀门，并且微流体通道两侧的防滑层抑制沿着所得界面的两种流体之间的对流混合。 根据本发明的实施方案的用于微流体自由界面的应用包括但不限于蛋白质结晶研究，蛋白质溶解度研究，流体系统的性质的确定以及各种生物测定如扩散免疫测定，底物转换测定 和竞争性结合测定。
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公开(公告)号：US20140174987A1
公开(公告)日：2014-06-26
申请号：US14236994
申请日：2012-07-30
申请人： Josef Find , Alfred Haas , Armin Brenner
发明人： Josef Find , Alfred Haas , Armin Brenner
CPC分类号： C10G65/14 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00495 , B01J2219/00585 , B01J2219/00698 , B01J2219/00707 , B01J2219/0072 , B01J2219/00747 , C10G29/02 , C10G45/22 , C40B30/08 , C40B60/12
摘要： The present invention relates to a process for handling product fluid streams which are obtained in the catalytic hydrogenation of liquid feeds in laboratory catalysis apparatuses. The liquid feeds are preferably hydrocarbons comprising sulfur- and nitrogen-comprising compounds as impurities. The hydrogenation serves to convert the impurities into hydrogen sulfide and ammonia which in this form can be readily separated off from the other constituents of the liquid feed. The product fluid streams are contacted with an inert gas stream, with the flow rate of the inert gas being a multiple of the flow rate of the product fluid stream. The formation of deposits in lines of the region on the outlet side of the reaction space can be effectively prevented by means of the process of the invention.
摘要翻译： 本发明涉及在实验室催化装置中在液体进料的催化氢化中获得的产物流体流的处理方法。 液体进料优选为包含含硫和氮的化合物作为杂质的烃。 氢化用于将杂质转化成硫化氢和氨，以这种形式可以容易地从液体进料的其它成分中分离。 产物流体流与惰性气体流接触，惰性气体的流速是产物流体流的流速的倍数。 通过本发明的方法可以有效地防止反应空间出口侧的区域中的沉积物的形成。
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公开(公告)号：US08709152B2
公开(公告)日：2014-04-29
申请号：US13213990
申请日：2011-08-19
IPC分类号： C30B7/14
CPC分类号： C30B7/14 , B01F5/00 , B01F13/0093 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/502738 , B01L3/502746 , B01L3/502769 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B81B1/00 , C30B29/02 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0017 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0086 , Y10T117/1004 , Y10T117/1008 , Y10T117/1012 , Y10T137/0318 , Y10T137/0324 , Y10T137/2224 , Y10T436/25
摘要： A static fluid and a second fluid are placed into contact along a microfluidic free interface and allowed to mix by diffusion without convective flow across the interface. In accordance with one embodiment of the present invention, the fluids are static and initially positioned on either side of a closed valve structure in a microfluidic channel having a width that is tightly constrained in at least one dimension. The valve is then opened, and no-slip layers at the sides of the microfluidic channel suppress convective mixing between the two fluids along the resulting interface. Applications for microfluidic free interfaces in accordance with embodiments of the present invention include, but are not limited to, protein crystallization studies, protein solubility studies, determination of properties of fluidics systems, and a variety of biological assays such as diffusive immunoassays, substrate turnover assays, and competitive binding assays.
摘要翻译： 将静态流体和第二流体沿微流体界面放置接触，并允许通过扩散混合而不对流流过该界面。 根据本发明的一个实施例，流体是静态的，并且最初位于微流体通道中的封闭阀结构的任一侧上，该微流体通道的宽度被紧紧地约束在至少一个维度上。 然后打开阀门，并且微流体通道两侧的防滑层抑制沿着所得界面的两种流体之间的对流混合。 根据本发明的实施方案的用于微流体自由界面的应用包括但不限于蛋白质结晶研究，蛋白质溶解度研究，流体系统的性质的确定以及各种生物测定如扩散免疫测定，底物转换测定 和竞争性结合测定。
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