Patent search ap:("Symyx Technologies Page Inc.") AND inv:"Eric D. Carlson"

1.

发明申请
High throughput mechanical property testing of materials libraries using capacitance 审中-公开
Title translation: 使用电容的材料库的高通量机械性能测试

公开(公告)号：US20040155668A1

公开(公告)日：2004-08-12

申请号：US10772522

申请日：2004-02-05

Applicant: Symyx Technologies, Inc.

Inventor： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev

IPC: G01R027/26

CPC classification number: G01N3/10 , B01J2219/00274 , B01J2219/00315 , B01J2219/00364 , B01J2219/00373 , B01J2219/00477 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00653 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00707 , B01J2219/00716 , B01J2219/00722 , B01J2219/00745 , B01J2219/0075 , B01J2219/00754 , B82Y30/00 , C40B40/14 , C40B40/18 , C40B50/14 , C40B60/14 , G01N3/18 , G01N2203/0016 , G01N2203/0252 , G01N2203/0254 , G01N2203/0258 , G01N2203/0617 , G01N2203/0623 , G01N2203/0641

Abstract: A method for high throughput mechanical property testing of materials libraries using capacitance. The method monitors the responses of a plurality of samples on a substrate to a force induced by a capacitor.

Abstract translation: 一种使用电容的材料库的高通量力学性能测试方法。该方法将衬底上的多个样品的响应监测为由电容器引起的力。

2.

发明申请
High throughput microbalance and methods of using same 有权
Title translation: 高通量微量天平及其使用方法

公开(公告)号：US20030218467A1

公开(公告)日：2003-11-27

申请号：US10155207

申请日：2002-05-24

Applicant: Symyx Technologies, Inc.

Inventor： Eric D. Carlson , Oleg Kolosov , Leonid Matsiev , Laura T. Mazzola , Mikhail Spitkovsky , John Gallipeo

IPC: G01R027/04 , G01R027/32

CPC classification number: G01N29/036 , B01J2219/00689 , B01J2219/00707 , G01G3/13 , G01N5/045 , G01N33/15 , G01N2291/0257

Abstract: A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate monitoring the response of a resonator holding a sample and correlating the response with mass change in the samples.

Abstract translation: 用于测量小样品量的质量的方法和装置。该方法和装置特别适于提供固体材料的微量天平测量作为组合研究程序的一部分。该方法和装置考虑监测保持样品的谐振器的响应并将响应与样本中的质量变化相关联。

3.

发明申请
High throughput mechanical property and bulge testing of materials libraries 失效
Title translation: 材料库的高通量机械性能和凸起试验

公开(公告)号：US20030041672A1

公开(公告)日：2003-03-06

申请号：US09939404

申请日：2001-08-24

Applicant: Symyx Technologies , Inc.

Inventor： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev

IPC: G01L001/24

CPC classification number: G01N3/18 , B01J2219/00274 , G01N3/10 , G01N2203/0016 , G01N2203/0051 , G01N2203/0252 , G01N2203/0254 , G01N2203/0258 , G01N2203/0617 , G01N2203/0623 , G01N2203/0641

Abstract: A method for high throughput mechanical property and bulge testing of materials libraries. A plurality of samples on a substrate are monitored for their response to a force from a fluid.

Abstract translation: 一种材料库高通量机械性能和凸起试验方法。监测基板上的多个样品对来自流体的力的响应。

4.

发明申请
Evaluating effects of exposure conditions on drug samples over time 审中-公开
Title translation: 评估暴露条件对药物样品随时间的影响

公开(公告)号：US20040219602A1

公开(公告)日：2004-11-04

申请号：US10790956

申请日：2004-03-01

Applicant: Symyx Technologies, Inc.

Inventor： Eric D. Carlson , Peter J. Desrosiers , Li Song

IPC: G01N033/53 , G01N033/543

CPC classification number: G01N33/15 , B01J2219/00599 , B01J2219/00686 , B01J2219/00702 , B01J2219/00756 , C40B60/12

Abstract: The present invention relates to the field of research for drug formulations. More particularly, this invention is directed toward an apparatus and method of performing parallel synthesis and screening of multiple drug compositions for stability and compatibility when exposed to various conditions over time, including various environmental and/or chemical conditions. In one aspect, the invention includes a method of testing for effects of a condition on a drug sample. The method includes providing an array of drug samples, simultaneously exposing a first plurality of the drug samples in the array to a first controlled condition for a period of time within an exposure period, and evaluating a plurality of the exposed drug samples at a first time and a second time using a non-destructive test in order to determine whether the condition has an affect on one or more of the drug samples over time. At least a portion of the exposure period between said first and second time, and the non-destructive test is the same each time.

Abstract translation: 本发明涉及药物制剂的研究领域。更具体地说，本发明涉及当暴露于包括各种环境和/或化学条件在内的各种条件时，在稳定性和相容性方面进行多种药物组合物的平行合成和筛选的装置和方法。一方面，本发明包括测试病症对药物样品的影响的方法。该方法包括提供药物样品阵列，同时将阵列内的第一组多个药物样品暴露于暴露期内的第一受控状态一段时间，以及在第一次评估多个暴露的药物样品并且第二次使用非破坏性测试来确定条件对一种或多种药物样品随时间的影响。所述第一次和第二次之间的曝光期间的至少一部分与无损检测每次相同。

5.

发明申请
High throughput mechanical property testing of materials libraries using a piezoelectric 审中-公开
Title translation: 使用压电材料库的高通量力学性能测试

公开(公告)号：US20040113602A1

公开(公告)日：2004-06-17

申请号：US10715159

申请日：2003-11-17

Applicant: Symyx Technologies, Inc.

Inventor： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev

IPC: G01N027/00

CPC classification number: B01J19/0046 , B01J2219/00315 , B01J2219/00364 , B01J2219/00369 , B01J2219/00376 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00698 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00756 , G01N3/10 , G01N3/18 , G01N2203/0016 , G01N2203/0051 , G01N2203/0252 , G01N2203/0254 , G01N2203/0258 , G01N2203/0617 , G01N2203/0623 , G01N2203/0641

Abstract: The present invention provides instruments and methods for screening combinatorial libraries that addresses many of the problems encountered when using conventional instruments. For example, the disclosed instruments can measure mechanical properties of library members in rapid serial or parallel test format, and can perform tests on small amounts of material, which are easily prepared or dispensed using art-disclosed liquid or solid handling techniques. Compared to conventional instruments, the disclosed instruments afford faster sample loading and unloading, for example, through the use of disposable libraries of material samples.

Abstract translation: 本发明提供了用于筛选组合文库的仪器和方法，其解决了使用常规仪器时遇到的许多问题。例如，所公开的仪器可以以快速的串联或并行测试方式测量文库成员的机械性能，并且可以使用本领域公开的液体或固体处理技术容易地制备或分配的少量材料进行测试。与常规仪器相比，所公开的仪器例如通过使用材料样品的一次性库来提供更快的样品加载和卸载。

6.

发明申请
High throughput preparation and analysis of materials 有权
Title translation: 高通量准备和材料分析

公开(公告)号：US20030127776A1

公开(公告)日：2003-07-10

申请号：US10291108

申请日：2002-11-08

Applicant: Symyx Technologies, Inc.

Inventor： Eric D. Carlson , Damian A. Hajduk , Leonid Matsiev , Adam Safir , Paul Mansky

IPC: G01B015/00 , B07B001/00 , B03B001/00

CPC classification number: B01L3/5085 , B01F5/104 , B01F7/00341 , B01F7/00416 , B01F7/082 , B01F13/1013 , B01F13/1022 , B01J19/0046 , B01J2219/00274 , B01J2219/00756 , B01L2200/12 , B01L2300/0812 , B01L2300/0829 , G01N1/286 , G01N35/00 , G01N35/00009 , G01N35/021 , G01N2001/2866 , G01N2035/00495 , G01N2035/00534

Abstract: A rapid throughput method for the preparation, analysis or both of libraries of material samples is provided. According to the method, a plurality of samples is provided. Providing the plurality of samples can include a variety of sample formation techniques including, but not limited to, extruding, milling, compression preparation, rotary mixing, microcentrifugation, molding and casting. Preferably, the samples are solidified into a near net shape configuration appropriate for testing of properties or characteristics of the samples.

Abstract translation: 提供了用于材料样品库的制备，分析或两者的快速通量方法。根据该方法，提供多个样品。提供多个样品可以包括各种样品形成技术，包括但不限于挤出，研磨，压缩制备，旋转混合，微量离心，模塑和铸造。优选地，样品被固化成适合于测试样品的性质或特性的近净形状构型。

7.

发明申请
High throughput testing of fluid samples using an electric field 审中-公开
Title translation: 使用电场对流体样品进行高通量测试

公开(公告)号：US20030203500A1

公开(公告)日：2003-10-30

申请号：US10133938

申请日：2002-04-26

Applicant: Symyx Technologies, Inc.

Inventor： Eric D. Carlson , Oleg Kolosov

IPC: G01N027/416

CPC classification number: G01N35/028 , B01J2219/00317 , B01J2219/00367 , B01J2219/00371 , B01J2219/00704 , B01J2219/00756 , G01N27/221

Abstract: A method for high throughput characterization of samples is disclosed. According to the method, a library of samples is exposed to one or more electric fields to determine properties of the samples.

Abstract translation: 公开了用于样品的高通量表征的方法。根据该方法，将样品库暴露于一个或多个电场以确定样品的性质。

8.

发明申请
High throughput crystallographic screening of materials 审中-公开
Title translation: 材料的高通量晶体筛选

公开(公告)号：US20030068829A1

公开(公告)日：2003-04-10

申请号：US10177185

申请日：2002-06-21

Applicant: Symyx Technologies, Inc.

Inventor： Daniel M. Giaquinta , Eric D. Carlson

IPC: G01N033/00

CPC classification number: G01N23/20 , Y10T436/24

Abstract: A method for characterization of a solid material sample, including the steps of providing a liquid medium for delivering a solid material sample to a porous substrate. Solid sample is separated from the liquid medium by filtering through the porous substrate. Analysis such as x-ray analysis of the solid sample is conducted while the sample resides on the porous substrate.

Abstract translation: 一种用于表征固体材料样品的方法，包括以下步骤：提供用于将固体材料样品输送到多孔基材的液体介质。通过过滤多孔基质将固体样品与液体介质分离。当样品驻留在多孔基材上时，进行诸如固体样品的X射线分析的分析。