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公开(公告)号：US20050107360A1
公开(公告)日：2005-05-19
申请号：US10967567
申请日：2004-10-18
IPC分类号： C07D223/16 , A61K31/55
CPC分类号： C07D223/16
摘要： The present invention relates to novel benzazepine derivatives of the following formula: wherein R1, R2, R3, R4 and R5, X, X′, Y and Y′ are as defined in the description and claims, processes for their preparation, pharmaceutical compositions containing said derivatives and their use for the preparation of medicaments useful for the prevention and treatment of diseases in which selective inhibition of monoamine oxidase B activity plays a role or is implicated.
摘要翻译： 本发明涉及下式的新型苯并氮杂衍生物：其中R 1，R 2，R 3，R 4， / SUP>和R 5，X，X'，Y和Y'如说明书和权利要求书中所定义，其制备方法，含有所述衍生物的药物组合物及其用于制备药物的用途 可用于预防和治疗单胺氧化酶B活性的选择性抑制发挥作用或牵连的疾病。
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公开(公告)号：US20070117791A1
公开(公告)日：2007-05-24
申请号：US11652970
申请日：2007-01-12
IPC分类号： A61K31/55
CPC分类号： C07D223/16
摘要： The present invention relates to methods for making and using novel benzazepine derivatives of the following formula: wherein R1, R2, R3, R4 and R5, X, X′, Y and Y′ are as defined in the description and claims, processes for their preparation, pharmaceutical compositions containing said derivatives and their use for the preparation of medicaments useful for the prevention and treatment of diseases in which selective inhibition of monoamine oxidase B activity plays a role or is implicated.
摘要翻译： 本发明涉及制备和使用下式的新型苯并氮杂衍生物的方法：其中R 1，R 2，R 3，R 3， 其中，X，X'，Y和Y'如说明书和权利要求书中所定义，其制备方法，含有所述衍生物的药物组合物及其用途 用于制备可用于预防和治疗单胺氧化酶B活性的选择性抑制发挥作用或牵连的疾病的药物。
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公开(公告)号：US20050283019A1
公开(公告)日：2005-12-22
申请号：US11213052
申请日：2005-08-26
IPC分类号： A61P3/00 , A61K31/15 , A61K31/167 , A61K31/216 , A61K31/275 , A61P3/04 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P29/00 , A61P43/00 , C07C231/02 , C07C233/15 , C07C233/25 , C07C233/33 , C07C233/60 , C07C235/16 , C07C237/04 , C07C237/22 , C07C243/14 , C07C243/28 , C07C255/19 , C07C255/23 , C07C255/25 , C07C255/58 , C07C259/06 , C07C323/41
CPC分类号： C07C259/06 , C07C233/15 , C07C233/25 , C07C233/33 , C07C233/60 , C07C235/16 , C07C237/04 , C07C237/22 , C07C243/14 , C07C243/28 , C07C255/19 , C07C255/23 , C07C255/25 , C07C323/41 , C07C2601/02
摘要： This invention relates to N-acylamino aryl derivatives of the formula where R1R21, R22, R23, R24, R3, R4, R5, R6, R7, R8, R, and n are as defined herein and where X is —CHRO, —OCHR—, —CH2S—, —SCH2—, —CH2CH2—, —CH═CH— or —C≡C—. The compounds of the invention are selective monoamine oxidase B inhibitors, and they are therefore useful in the treatment of diseases mediated by monoamine oxidase B, for example, for the treatment of Alzheimer's disease or senile dementia.
摘要翻译： 本发明涉及下式的N-酰基氨基芳基衍生物：其中R 1，R 2，R 22，R 23， >，R 24，R 3，R 4，R 5，R 6， R 7，R 8，R 8和n如本文所定义，并且其中X是-CHRO，-OCHR - ， - CH 2 ，-SCH 2 - ， - CH 2 CH 2 - ， - CH-CH-或-C≡C-。 本发明的化合物是选择性单胺氧化酶B抑制剂，因此它们可用于治疗由单胺氧化酶B介导的疾病，例如用于治疗阿尔茨海默氏病或老年痴呆症。
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4.发明申请Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors 失效苯甲酰哌啶衍生物作为5-HT2A和D3受体的双重调节剂公开(公告)号：US20070197531A1
公开(公告)日：2007-08-23
申请号：US11705635
申请日：2007-02-13
申请人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Rodriguez Sarmiento , Lucinda Steward
发明人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Rodriguez Sarmiento , Lucinda Steward
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4709 , A61K31/4545 , C07D401/02 , C07D413/02
CPC分类号： C07D401/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r are as defined in the specification.
摘要翻译： 本发明涉及通用作为可用于中枢神经系统疾病的5-HT 2a和D 3 N受体的双重调节剂的化合物，其中A，R 1 ，R 2，n，p，q和r如说明书中所定义。
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公开(公告)号：US20080103174A1
公开(公告)日：2008-05-01
申请号：US11876007
申请日：2007-10-22
IPC分类号： A61K31/47 , A61K31/454 , C07D215/14 , C07D401/02
CPC分类号： C07D401/12 , C07D211/46 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to ether derivatives according to general formula I, and to their pharmaceutically-acceptable salts, which may be used in treating or preventing cognitive disorders, drug addiction, depression, anxiety, drug dependence, dementias, memory impairment, psychotic disorders comprising schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, or psychoses comprising paranoia and delusions.
摘要翻译： 本发明涉及根据通式I的醚衍生物及其药学上可接受的盐，其可用于治疗或预防认知障碍，药物成瘾，抑郁，焦虑，药物依赖，痴呆，记忆障碍，精神病，包括 精神分裂症，分裂情感障碍，双相性精神障碍，躁狂症，精神病性抑郁症或精神病，包括偏执狂和妄想。
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公开(公告)号：US20070123526A1
公开(公告)日：2007-05-31
申请号：US11605005
申请日：2006-11-28
申请人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Rosa Rodriguez Sarmiento , Sven Taylor
发明人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Rosa Rodriguez Sarmiento , Sven Taylor
IPC分类号： A61K31/541 , C07D417/14
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compounds of formula I wherein R1, R2 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和G如说明书和权利要求及其药学上可接受的盐所定义。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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