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1.发明申请Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors 失效苯甲酰哌啶衍生物作为5-HT2A和D3受体的双重调节剂公开(公告)号：US20070197531A1
公开(公告)日：2007-08-23
申请号：US11705635
申请日：2007-02-13
申请人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Rodriguez Sarmiento , Lucinda Steward
发明人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Rodriguez Sarmiento , Lucinda Steward
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4709 , A61K31/4545 , C07D401/02 , C07D413/02
CPC分类号： C07D401/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r are as defined in the specification.
摘要翻译： 本发明涉及通用作为可用于中枢神经系统疾病的5-HT 2a和D 3 N受体的双重调节剂的化合物，其中A，R 1 ，R 2，n，p，q和r如说明书中所定义。
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公开(公告)号：US20080103174A1
公开(公告)日：2008-05-01
申请号：US11876007
申请日：2007-10-22
IPC分类号： A61K31/47 , A61K31/454 , C07D215/14 , C07D401/02
CPC分类号： C07D401/12 , C07D211/46 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to ether derivatives according to general formula I, and to their pharmaceutically-acceptable salts, which may be used in treating or preventing cognitive disorders, drug addiction, depression, anxiety, drug dependence, dementias, memory impairment, psychotic disorders comprising schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, or psychoses comprising paranoia and delusions.
摘要翻译： 本发明涉及根据通式I的醚衍生物及其药学上可接受的盐，其可用于治疗或预防认知障碍，药物成瘾，抑郁，焦虑，药物依赖，痴呆，记忆障碍，精神病，包括 精神分裂症，分裂情感障碍，双相性精神障碍，躁狂症，精神病性抑郁症或精神病，包括偏执狂和妄想。
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公开(公告)号：US20090029977A1
公开(公告)日：2009-01-29
申请号：US12175476
申请日：2008-07-18
IPC分类号： A61K31/454 , C07D261/20 , C07D413/14 , A61K31/541 , A61P25/18 , A61K31/5377 , C07D279/12
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to compounds of the formula (I) wherein R1, R2, X and n are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，X和n如说明书中所定义，作为5-羟色胺5-HT2a和多巴胺D3受体的双重调节剂，其制备方法，含有它们的药物组合物及其用途 用于治疗精神病，以及其他疾病如抑郁和焦虑，药物依赖，痴呆和记忆障碍。
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公开(公告)号：US20120040972A1
公开(公告)日：2012-02-16
申请号：US13280523
申请日：2011-10-25
IPC分类号： A61K31/454 , C07D413/14 , A61P25/18 , C07D417/14 , A61K31/541 , A61K31/4545 , C07D413/04 , A61K31/5377
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to compounds of the formula (I) wherein R1, R2, X and n are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，X和n如说明书中所定义，作为5-羟色胺5-HT2a和多巴胺D3受体的双重调节剂，其制备方法，含有它们的药物组合物及其用途 用于治疗精神病，以及其他疾病如抑郁和焦虑，药物依赖，痴呆和记忆障碍。
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5.发明申请BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS 失效作为5-HT2A和D3受体双重调节剂的苯甲酰哌啶衍生物公开(公告)号：US20120004208A1
公开(公告)日：2012-01-05
申请号：US13233056
申请日：2011-09-15
申请人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Lucinda Steward
发明人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Lucinda Steward
IPC分类号： A61K31/451 , C07D413/08 , A61K31/454 , C07D215/48 , A61K31/4709 , A61P25/18 , A61K31/4545 , C07D409/08 , A61K31/496 , A61K31/5377 , C07D417/08 , C07D211/26 , C07D401/08
CPC分类号： C07D401/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r are as defined in the specification.
摘要翻译： 本发明涉及通式的化合物作为可用于CNS障碍的5-HT2a和D3受体的双重调节剂，其中A，R1，R2，n，p，q和r如说明书中所定义。
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6.发明授权Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors 失效苯甲酰哌啶衍生物作为5-HT2A和D3受体的双重调节剂公开(公告)号：US08415350B2
公开(公告)日：2013-04-09
申请号：US13233056
申请日：2011-09-15
申请人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Lucinda Steward
发明人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Lucinda Steward
IPC分类号： A61K31/496 , A61K31/5377 , C07D401/08 , C07D417/08
CPC分类号： C07D401/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r are as defined in the specification.
摘要翻译： 本发明涉及通式的化合物作为可用于CNS障碍的5-HT2a和D3受体的双重调节剂，其中A，R1，R2，n，p，q和r如说明书中所定义。
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7.发明授权Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors 失效苯甲酰哌啶衍生物作为5-HT2A和D3受体的双重调节剂公开(公告)号：US08039490B2
公开(公告)日：2011-10-18
申请号：US11705635
申请日：2007-02-13
申请人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Maria Rodriguez Sarmiento , Lucinda Steward
发明人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Maria Rodriguez Sarmiento , Lucinda Steward
IPC分类号： A61K31/445 , C07D211/32
CPC分类号： C07D401/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r are as defined in the specification.
摘要翻译： 本发明涉及通式的化合物作为可用于CNS障碍的5-HT2a和D3受体的双重调节剂，其中A，R1，R2，n，p，q和r如说明书中所定义。
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8.发明授权Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors 失效苯甲酰哌啶衍生物作为5-HT2A和D3受体的双重调节剂公开(公告)号：US08097637B2
公开(公告)日：2012-01-17
申请号：US12184272
申请日：2008-08-01
IPC分类号： A61K31/445 , C07D211/32
CPC分类号： C07D211/32 , C07D405/12
摘要： The present invention relates to compounds of formula (I) wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D3 and serotonin (5-Hydroxytryptamine; 5-HT) 5-HT2A receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.
摘要翻译： 本发明涉及式（I）化合物，其中R 1和A如说明书中定义为5-羟色胺5-HT2a和多巴胺D3受体的双重调节剂，其制备方法，含有它们的药物组合物及其作为药物的用途。 通式（I）的化合物对多巴胺D3和5-羟色胺（5-羟色胺，5-HT）5-HT 2A受体具有高亲和力，并且有效治疗精神病，以及其它疾病如抑郁和焦虑， 药物依赖，痴呆和记忆障碍。
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![Benzo[D]isoxazol-3-yl-piperazin derivatives useful as modulators of dopamine D3 receptors](/abs-image/US/2011/05/10/US07939535B2/abs.jpg.150x150.jpg)
9.发明授权Benzo[D]isoxazol-3-yl-piperazin derivatives useful as modulators of dopamine D3 receptors 失效苯并[D]异恶唑-3-基 - 哌嗪衍生物，可用作多巴胺D3受体的调节剂公开(公告)号：US07939535B2
公开(公告)日：2011-05-10
申请号：US12560471
申请日：2009-09-16
IPC分类号： A61K31/497 , C07D419/04
CPC分类号： C07D413/04
摘要： The present invention provides compounds of the general formula (I), having affinity and selectivity for the dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the therapeutic and/or prophylactic treatment of cognitive disorders.
摘要翻译： 本发明提供对多巴胺D3受体具有亲和性和选择性的通式（I）化合物，其制备方法，含有它们的药物组合物及其用于认知障碍治疗和/或预防性治疗的用途。
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10.发明申请PYRIDINYLPIPERAZIN DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS 审中-公开作为DOPAMINE D3受体的调节剂有用的吡啶并吡啶衍生物公开(公告)号：US20100075979A1
公开(公告)日：2010-03-25
申请号：US12560463
申请日：2009-09-16
IPC分类号： A61K31/496 , C07D401/04
CPC分类号： C07D213/74
摘要： The present invention provides compounds of provides formula I, having affinity and selectivity for the dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the therapeutic and/or prophylactic treatment of cognitive disorders.
摘要翻译： 本发明提供了提供式I的化合物，其具有对多巴胺D3受体的亲和力和选择性，其制备，含有它们的药物组合物及其用于认知障碍的治疗和/或预防性治疗的用途。
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