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    8-Alkoxy or cycloalkoxy-4-methyl-3,4-dihydro-quinazolin-2-ylamines
    7.
    发明申请
    8-Alkoxy or cycloalkoxy-4-methyl-3,4-dihydro-quinazolin-2-ylamines 失效
    8-烷氧基或环烷氧基-4-甲基-3,4-二氢 - 喹唑啉-2-基胺

    公开(公告)号：US20060293350A1

    公开(公告)日：2006-12-28

    申请号：US11472084

    申请日：2006-06-21

    申请人： Alexander Alanine ,  Luca Gobbi ,  Sabine Kolczewski ,  Thomas Luebbers ,  Jens-Uwe Peters ,  Lucinda Steward

    发明人： Alexander Alanine ,  Luca Gobbi ,  Sabine Kolczewski ,  Thomas Luebbers ,  Jens-Uwe Peters ,  Lucinda Steward

    IPC分类号： A61K31/517 ,  C07D239/84

    CPC分类号： C07D239/84

    摘要： The present invention relates to compounds of formula wherein R1, R2, R3, and n are as described in the specification and pharmaceutically acceptable acid addition salts thereof. The compounds of formula I can be used for the treatment of 5-HT5A receptor antagonists related diseases, which include depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, disorders of eating behaviors, sexual dysfunction, sleep disorders, withdrawal from abuse of drugs, motor disorders such as Parkinson's disease, dementia in Parkinson's disease, neuroleptic-induced Parkinsonism and tardive dyskinesias, as well as other psychiatric disorders and gastrointestinal disorders such as irritable bowel syndrome.

    摘要翻译： 本发明涉及下式的化合物，其中R 1，R 2，R 3和n如说明书和药学上可接受的那样 其酸加成盐。 式I化合物可用于治疗5-HT 5A受体拮抗剂相关疾病，其包括抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐惧症，社交恐惧症，强迫症，后期 创伤性应激障碍，疼痛，记忆障碍，饮食行为障碍，性功能障碍，睡眠障碍，戒除药物，运动障碍如帕金森病，帕金森病痴呆，精神分裂症引起的帕金森综合征和迟发性运动障碍，以及 其他精神疾病和胃肠道疾病如肠易激综合征。