公开(公告)号：US20170313675A1

公开(公告)日：2017-11-02

申请号：US15517473

申请日：2015-10-02

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Simone Bigi ,  Walter Keung ,  Steve Swann ,  Phong H. Vu ,  Steven John Woodhead ,  Anthony R. Gangloff

IPC: C07D401/04 ,  C07D413/14 ,  A61K31/497 ,  C07D401/14 ,  C07D241/20 ,  C07D491/10 ,  C07D403/12 ,  C07D401/00

CPC classification number: C07D401/04 ,  A61K31/497 ,  C07D241/20 ,  C07D401/00 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D491/10

Abstract: Disclosed are compounds of formula 1: which are useful as inhibitors of TBK1. Also disclosed are pharmaceutical compositions which contain the compounds, methods for treatment of conditions associated with TBK1, and processes for making the compounds and intermediates thereof.

公开(公告)号：US11236099B2

公开(公告)日：2022-02-01

申请号：US16622632

申请日：2018-06-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Kazuaki Takami ,  Masaki Seto ,  Shinobu Sasaki ,  Haruhi Ando ,  Masaki Ogino ,  Tomoko Ohashi ,  Toshihiro Imaeda ,  Ikuo Fujimori ,  Yasuhiro Tsukimi ,  Masami Yamada ,  Kenichiro Shimokawa ,  Takeshi Wakabayashi ,  Masataka Murakami ,  Makoto Fushimi ,  Tomohiro Okawa ,  Jinichi Yonemori ,  Tomohiro Ohashi ,  Hideo Suzuki ,  Hironobu Maezaki ,  Ayumu Sato ,  Yasutomi Asano ,  Steve Swann

IPC: C07D491/048 ,  A61K31/4355 ,  A61P1/10

Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US20220017530A1

公开(公告)日：2022-01-20

申请号：US17475733

申请日：2021-09-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Kazuaki Takami ,  Masaki Seto ,  Shinobu Sasaki ,  Haruhi Ando ,  Masaki Ogino ,  Tomoko Ohashi ,  Toshihiro Imaeda ,  Ikuo Fujimori ,  Yasuhiro Tsukimi ,  Masami Yamada ,  Kenichiro Shimokawa ,  Takeshi Wakabayashi ,  Masataka Murakami ,  Makoto Fushimi ,  Tomohiro Okawa ,  Jinichi Yonemori ,  Tomohiro Ohashi ,  Hideo Suzuki ,  Hironobu Maezaki ,  Ayumu Sato ,  Yasutomi Asano ,  Steve Swann

IPC: C07D491/048 ,  A61P1/10 ,  A61K31/4355

Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US09994547B2

公开(公告)日：2018-06-12

申请号：US15517473

申请日：2015-10-02

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Simone Bigi ,  Walter Keung ,  Steve Swann ,  Phong H. Vu ,  Steven John Woodhead ,  Anthony R. Gangloff

IPC: A61K31/497 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D491/10 ,  C07D401/04 ,  C07D241/20 ,  C07D401/00

CPC classification number: C07D401/04 ,  A61K31/497 ,  C07D241/20 ,  C07D401/00 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D491/10

Abstract: Disclosed are compounds of formula 1: which are useful as inhibitors of TBK1. Also disclosed are pharmaceutical compositions which contain the compounds, methods for treatment of conditions associated with TBK1, and processes for making the compounds and intermediates thereof.