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公开(公告)号：US10807987B2
公开(公告)日：2020-10-20
申请号：US16366710
申请日：2019-03-27
发明人： Yuya Oguro , Shigemitsu Matsumoto , Takeshi Wakabayashi , Norihito Tokunaga , Taku Kamei , Mitsuhiro Ito , Satoshi Mikami , Masaki Seto , Shinji Morimoto , Shinji Nakamura , Sachie Takashima , Masataka Murakami , Masaki Daini , Makoto Kamata , Minoru Nakamura , Yasufumi Wada , Hiroyuki Kakei , Kazuaki Takami , Taisuke Tawaraishi , Jumpei Aida , Kouichi Iwanaga , Satoshi Yamamoto
IPC分类号： C07D487/04 , A61K9/20 , A61K9/48 , C07D471/04 , A61P25/00
摘要： The present invention provides a heterocyclic compound having an antagonistic action on an NMDA receptor containing the NR2B subunit, and expected to be useful as an agent for the prophylaxis or treatment of major depression, bipolar disorder, migraine, pain, behavioral and psychological symptoms of dementia and the like.The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.
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公开(公告)号：US10548877B2
公开(公告)日：2020-02-04
申请号：US16083295
申请日：2017-03-09
发明人： Masaki Ogino , Eiji Kimura , Shinkichi Suzuki , Kouji Fuji , Tomohiro Ohashi , Makoto Fushimi , Kei Masuda , Tatsuki Koike , Takeshi Wakabayashi , Jinichi Yonemori , Masami Yamada
IPC分类号： A61K31/4192 , A61K31/415 , A61K31/4155 , A61K31/427 , A61K31/4406 , A61K31/4439 , A61P25/20 , A61P25/28 , A61P25/18 , A61P25/16 , C07D213/56 , C07D231/12 , C07D249/06 , C07D401/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要： Provided is a compound having a cholinergic muscarine M1 receptor positive allosteric modulator activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a cholinergic muscarine M1 receptor positive allosteric modulator activity, and is useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like.
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公开(公告)号：US11952344B2
公开(公告)日：2024-04-09
申请号：US17754118
申请日：2020-09-25
发明人： Yuya Oguro , Makoto Kamata , Shuhei Ikeda , Takeshi Wakabayashi , Norihito Tokunaga , Taku Kamei , Mitsuhiro Ito , Shigemitsu Matsumoto , Hirotaka Kamitani , Takaharu Hirayama , Toshio Tanaka , Hiroshi Banno , Nobuyuki Takakura , Jinichi Yonemori , Takuya Fujimoto
IPC分类号： C07D213/61 , A61K31/444 , A61K31/495 , A61P25/00 , A61P29/00 , C07D211/04 , C07D213/65 , C07D213/68 , C07D221/04 , C07D237/08 , C07D239/26 , C07D239/34 , C07D333/38 , C07D401/12 , C07D405/02
CPC分类号： C07D211/04 , C07D237/08 , C07D239/26 , C07D405/02
摘要： Provided is a heterocyclic compound that can have an antagonistic action on an NMD A receptor containing the NR2B subunit and that is expected to be useful as a prophylactic or therapeutic agent for depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I), wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20230399323A1
公开(公告)日：2023-12-14
申请号：US18022800
申请日：2021-08-24
申请人： NATIONAL INSTITUTES FOR QUANTUM SCIENCE AND TECHNOLOGY , Eisai R&D Management Co., Ltd. , Ono Pharmaceutical Co., Ltd. , TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人： Makoto Higuchi , Maiko Ono , Meiei Cho , Takeshi Yamamoto , Takeshi Wakabayashi
IPC分类号： C07D417/06 , A61K51/04 , A61K49/00
CPC分类号： C07D417/06 , A61K51/0459 , A61K49/0021
摘要： An embodiment of the present invention relates to a compound represented by formula (I) or (II), a pharmaceutically acceptable salt thereof, or a solvate thereof.
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公开(公告)号：US20220017530A1
公开(公告)日：2022-01-20
申请号：US17475733
申请日：2021-09-15
发明人： Kazuaki Takami , Masaki Seto , Shinobu Sasaki , Haruhi Ando , Masaki Ogino , Tomoko Ohashi , Toshihiro Imaeda , Ikuo Fujimori , Yasuhiro Tsukimi , Masami Yamada , Kenichiro Shimokawa , Takeshi Wakabayashi , Masataka Murakami , Makoto Fushimi , Tomohiro Okawa , Jinichi Yonemori , Tomohiro Ohashi , Hideo Suzuki , Hironobu Maezaki , Ayumu Sato , Yasutomi Asano , Steve Swann
IPC分类号： C07D491/048 , A61P1/10 , A61K31/4355
摘要： The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US11236099B2
公开(公告)日：2022-02-01
申请号：US16622632
申请日：2018-06-19
发明人： Kazuaki Takami , Masaki Seto , Shinobu Sasaki , Haruhi Ando , Masaki Ogino , Tomoko Ohashi , Toshihiro Imaeda , Ikuo Fujimori , Yasuhiro Tsukimi , Masami Yamada , Kenichiro Shimokawa , Takeshi Wakabayashi , Masataka Murakami , Makoto Fushimi , Tomohiro Okawa , Jinichi Yonemori , Tomohiro Ohashi , Hideo Suzuki , Hironobu Maezaki , Ayumu Sato , Yasutomi Asano , Steve Swann
IPC分类号： C07D491/048 , A61K31/4355 , A61P1/10
摘要： The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US11230541B2
公开(公告)日：2022-01-25
申请号：US16634402
申请日：2018-07-26
发明人： Eiji Kimura , Masaki Ogino , Yasuhisa Kohara , Tomoko Ohashi , Tomohiro Kaku , Yuya Oguro , Shigemitsu Matsumoto , Takeshi Wakabayashi , Norihito Tokunaga , Taku Kamei , Mitsuhiro Ito
IPC分类号： C07D409/12 , C07D401/12 , C07D249/18 , A61P25/28 , A61P25/24 , A61P25/06 , A61K9/20 , A61K9/48 , C07D231/56 , C07D235/06
摘要： Provided is a heterocyclic compound that can have an antagonistic action on an NMDA receptor containing the NR2B subunit, and is expected to be useful as a prophylactic or therapeutic agent for major depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US11713311B2
公开(公告)日：2023-08-01
申请号：US17550173
申请日：2021-12-14
发明人： Eiji Kimura , Masaki Ogino , Yasuhisa Kohara , Tomoko Ohashi , Tomohiro Kaku , Yuya Oguro , Shigemitsu Matsumoto , Takeshi Wakabayashi , Norihito Tokunaga , Taku Kamei , Mitsuhiro Ito
IPC分类号： C07D409/12 , C07D401/12 , A61P25/28 , A61P25/24 , A61P25/06 , A61K9/20 , A61K9/48 , C07D231/56 , C07D235/06 , C07D249/18
CPC分类号： C07D409/12 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K9/2095 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61P25/06 , A61P25/24 , A61P25/28 , C07D231/56 , C07D235/06 , C07D249/18 , C07D401/12
摘要： Provided is a heterocyclic compound that can have an antagonistic action on an NMDA receptor containing the NR2B subunit, and is expected to be useful as a prophylactic or therapeutic agent for major depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I):
wherein each symbol is as described in the DESCRIPTION, or a salt thereof.-
公开(公告)号：US11702419B2
公开(公告)日：2023-07-18
申请号：US17201878
申请日：2021-03-15
发明人： Yuya Oguro , Shigemitsu Matsumoto , Takeshi Wakabayashi , Norihito Tokunaga , Taku Kamei , Mitsuhiro Ito , Satoshi Mikami , Masaki Seto , Shinji Morimoto , Shinji Nakamura , Sachie Takashima , Masataka Murakami , Masaki Daini , Makoto Kamata , Minoru Nakamura , Yasufumi Wada , Hiroyuki Kakei , Kazuaki Takami , Taisuke Tawaraishi , Jumpei Aida , Kouichi Iwanaga , Satoshi Yamamoto
IPC分类号： C07D487/04 , A61K9/20 , A61K9/48 , C07D471/04 , A61P25/00
CPC分类号： C07D487/04 , A61K9/2095 , A61K9/4833 , A61P25/00 , C07D471/04
摘要： The present invention provides a heterocyclic compound having an antagonistic action on an NMDA receptor containing the NR2B subunit, and expected to be useful as an agent for the prophylaxis or treatment of major depression, bipolar disorder, migraine, pain, behavioral and psychological symptoms of dementia and the like.
The present invention relates to a compound represented by the formula (I):
wherein each symbol is as described in the description, or a salt thereof.
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