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公开(公告)号：US20150045349A1
公开(公告)日：2015-02-12
申请号：US14379343
申请日：2013-02-19
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Hiroyuki Nagamiya , Masato Yoshida , Masaki Seto , Shogo Marui , Tsuneo Oda , Yuji Ishichi , Hideo Suzuki , Tomokazu Kusumoto , Takatoshi Yogo , Chul Yun Rhim , Cheolhwan Yoon , Gil Nam Lee , Hyun Bin Kang , Kwang Ok Kim , Hye Sun Jeon
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D519/00
Abstract: The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US11034700B2
公开(公告)日：2021-06-15
申请号：US16491794
申请日：2018-03-07
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Satoshi Mikami , Masaki Daini , Yuhei Miyanohana , Hideo Suzuki , Kenichiro Shimokawa , Yuichi Kajita , Masaki Ogino , Tatsuki Koike , Kohei Takeuchi
IPC: A61K31/40 , C07D491/107 , C07D207/12 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/10 , C07D409/06 , C07D409/12 , C07D413/10 , C07D413/12
Abstract: The present invention provides a substituted pyrrolidine compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US09382188B2
公开(公告)日：2016-07-05
申请号：US14377953
申请日：2013-02-12
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata , Akito Shibuya
IPC: C07C59/135 , C07D405/14 , C07C255/46 , C07D309/06 , C07D231/12 , C07D333/38 , C07D401/12 , C07D239/26 , C07D239/34 , C07C317/44 , C07C229/34 , C07C233/47 , C07D271/10 , C07D277/24 , C07C255/37 , C07D285/12 , C07D213/30 , C07D213/55 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07C59/68 , C07C59/70 , C07C59/72 , C07D213/12 , C07C309/65 , C07C309/66 , C07C311/21 , C07C323/56 , C07C235/34 , C07C255/41
CPC classification number: C07C59/135 , C07C59/68 , C07C59/70 , C07C59/72 , C07C229/34 , C07C233/47 , C07C235/34 , C07C255/37 , C07C255/41 , C07C255/46 , C07C309/65 , C07C309/66 , C07C311/21 , C07C317/44 , C07C323/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/12 , C07D213/30 , C07D213/55 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D231/12 , C07D239/26 , C07D239/34 , C07D271/10 , C07D277/24 , C07D285/12 , C07D309/06 , C07D333/38 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14
Abstract: Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
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公开(公告)号：US20150045378A1
公开(公告)日：2015-02-12
申请号：US14377951
申请日：2013-02-12
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata
IPC: C07D213/64 , C07D403/12 , C07D405/14 , C07D401/12 , C07D213/55
CPC classification number: C07D213/64 , C07D213/30 , C07D213/55 , C07D213/68 , C07D213/69 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/14
Abstract: Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
Abstract translation: 提供具有GPR40激动剂活性的芳环化合物。 由式（I）表示的化合物：其中每个符号如说明书所述，或其盐具有GPR40激动剂活性，并且可用作预防或治疗糖尿病等的药剂。
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Patent Agency Ranking
公开(公告)号：US11236099B2
公开(公告)日：2022-02-01
申请号：US16622632
申请日：2018-06-19
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Kazuaki Takami , Masaki Seto , Shinobu Sasaki , Haruhi Ando , Masaki Ogino , Tomoko Ohashi , Toshihiro Imaeda , Ikuo Fujimori , Yasuhiro Tsukimi , Masami Yamada , Kenichiro Shimokawa , Takeshi Wakabayashi , Masataka Murakami , Makoto Fushimi , Tomohiro Okawa , Jinichi Yonemori , Tomohiro Ohashi , Hideo Suzuki , Hironobu Maezaki , Ayumu Sato , Yasutomi Asano , Steve Swann
IPC: C07D491/048 , A61K31/4355 , A61P1/10
Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US09181186B2
公开(公告)日：2015-11-10
申请号：US14377951
申请日：2013-02-12
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata
IPC: C07D213/64 , C07D405/14 , C07D401/12 , C07D239/34 , C07D213/30 , C07D213/68 , C07D213/69 , C07D213/55 , C07D403/12
CPC classification number: C07D213/64 , C07D213/30 , C07D213/55 , C07D213/68 , C07D213/69 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/14
Abstract: Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
Abstract translation: 提供具有GPR40激动剂活性的芳环化合物。 由式（I）表示的化合物：其中每个符号如说明书所述，或其盐具有GPR40激动剂活性，并且可用作预防或治疗糖尿病等的药剂。
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公开(公告)号：US20220017530A1
公开(公告)日：2022-01-20
申请号：US17475733
申请日：2021-09-15
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Kazuaki Takami , Masaki Seto , Shinobu Sasaki , Haruhi Ando , Masaki Ogino , Tomoko Ohashi , Toshihiro Imaeda , Ikuo Fujimori , Yasuhiro Tsukimi , Masami Yamada , Kenichiro Shimokawa , Takeshi Wakabayashi , Masataka Murakami , Makoto Fushimi , Tomohiro Okawa , Jinichi Yonemori , Tomohiro Ohashi , Hideo Suzuki , Hironobu Maezaki , Ayumu Sato , Yasutomi Asano , Steve Swann
IPC: C07D491/048 , A61P1/10 , A61K31/4355
Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US09085578B2
公开(公告)日：2015-07-21
申请号：US14379343
申请日：2013-02-19
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Hiroyuki Nagamiya , Masato Yoshida , Masaki Seto , Shogo Marui , Tsuneo Oda , Yuji Ishichi , Hideo Suzuki , Tomokazu Kusumoto , Takatoshi Yogo , Chul Yun Rhim , Cheolhwan Yoon , Gil Nam Lee , Hyun Bin Kang , Kwang Ok Kim , Hye Sun Jeon
IPC: C07D401/14 , A61K31/437 , C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , C07D519/00
Abstract: The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
Abstract translation: 本发明提供了一种用于预防或治疗自身免疫性疾病（例如牛皮癣，类风湿性关节炎，炎性肠病，干燥综合征，白塞病，多发性硬化，系统性红斑狼疮等）等，其具有优异的Tyk2 抑制作用。 本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。
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公开(公告)号：US20150018422A1
公开(公告)日：2015-01-15
申请号：US14377953
申请日：2013-02-12
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata , Akito Shibuya
IPC: C07C59/135
CPC classification number: C07C59/135 , C07C59/68 , C07C59/70 , C07C59/72 , C07C229/34 , C07C233/47 , C07C235/34 , C07C255/37 , C07C255/41 , C07C255/46 , C07C309/65 , C07C309/66 , C07C311/21 , C07C317/44 , C07C323/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/12 , C07D213/30 , C07D213/55 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D231/12 , C07D239/26 , C07D239/34 , C07D271/10 , C07D277/24 , C07D285/12 , C07D309/06 , C07D333/38 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14
Abstract: Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
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