公开(公告)号：US09464060B2

公开(公告)日：2016-10-11

申请号：US14463780

申请日：2014-08-20

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： William Buffham ,  Hannah Canning ,  Richard Davenport ,  William Farnaby ,  Stephen Mack ,  Alka Parmar ,  Susanne Wright

IPC: C07D239/34 ,  C07D213/78 ,  C07D213/81 ,  C07C235/52 ,  C07C235/46

CPC classification number: C07D239/34 ,  A61K31/195 ,  A61K31/277 ,  A61K31/44 ,  A61K31/505 ,  C07C235/44 ,  C07C235/46 ,  C07C235/52 ,  C07C255/54 ,  C07C2601/02 ,  C07C2601/04 ,  C07D213/78 ,  C07D213/81

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, X, m, R2, Y, R3, Z, n, R4, A and B are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

公开(公告)号：US20180072714A1

公开(公告)日：2018-03-15

申请号：US15558824

申请日：2016-03-17

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Saleh Ahmed ,  Gregory Barker ,  Hannah Canning ,  Richard Davenport ,  David Harrison ,  Kerry Jenkins ,  David Livermore ,  Susanne Wright ,  Natasha Kinsella

IPC: C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, Y1, Y2, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

公开(公告)号：US20190010129A1

公开(公告)日：2019-01-10

申请号：US15999570

申请日：2018-08-20

Applicant: Takeda Pharmaceutical Company Limited

Inventor： William Buffham ,  Hannah Canning ,  Richard Davenport ,  William Farnaby ,  Stephen Mack ,  Alka Parmar ,  Susanne Wright

IPC: C07D239/34 ,  C07C255/54 ,  A61K31/44 ,  A61K31/505 ,  C07C235/44 ,  C07D213/81 ,  A61K31/277 ,  C07D213/78 ,  C07C235/46 ,  C07C235/52 ,  A61K31/195

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, formula (I) wherein R1, X, m, R2, Y, R3, Z, n, R4, A and B are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

公开(公告)号：US10287286B2

公开(公告)日：2019-05-14

申请号：US15558824

申请日：2016-03-17

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Saleh Ahmed ,  Gregory Barker ,  Hannah Canning ,  Richard Davenport ,  David Harrison ,  Kerry Jenkins ,  David Livermore ,  Susanne Wright ,  Natasha Kinsella

IPC: C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, Y1, Y2, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

公开(公告)号：US10100018B2

公开(公告)日：2018-10-16

申请号：US14913135

申请日：2014-08-20

Applicant: Takeda Pharmaceutical Company Limited

Inventor： William Buffham ,  Hannah Canning ,  Richard Davenport ,  William Farnaby ,  Stephen Mack ,  Alka Parmar ,  Susanne Wright

IPC: C07C235/52 ,  A61P29/00 ,  C07D239/34 ,  C07D213/81 ,  C07C235/46 ,  C07D213/78 ,  A61K31/195 ,  A61K31/277 ,  A61K31/44 ,  A61K31/505 ,  C07C235/44 ,  C07C255/54

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, X, m, R2, Y, R3, Z, n, R4, A and B are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.