公开(公告)号：US09464060B2

公开(公告)日：2016-10-11

申请号：US14463780

申请日：2014-08-20

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： William Buffham ,  Hannah Canning ,  Richard Davenport ,  William Farnaby ,  Stephen Mack ,  Alka Parmar ,  Susanne Wright

IPC: C07D239/34 ,  C07D213/78 ,  C07D213/81 ,  C07C235/52 ,  C07C235/46

CPC classification number: C07D239/34 ,  A61K31/195 ,  A61K31/277 ,  A61K31/44 ,  A61K31/505 ,  C07C235/44 ,  C07C235/46 ,  C07C235/52 ,  C07C255/54 ,  C07C2601/02 ,  C07C2601/04 ,  C07D213/78 ,  C07D213/81

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, X, m, R2, Y, R3, Z, n, R4, A and B are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

公开(公告)号：US10100018B2

公开(公告)日：2018-10-16

申请号：US14913135

申请日：2014-08-20

Applicant: Takeda Pharmaceutical Company Limited

Inventor： William Buffham ,  Hannah Canning ,  Richard Davenport ,  William Farnaby ,  Stephen Mack ,  Alka Parmar ,  Susanne Wright

IPC: C07C235/52 ,  A61P29/00 ,  C07D239/34 ,  C07D213/81 ,  C07C235/46 ,  C07D213/78 ,  A61K31/195 ,  A61K31/277 ,  A61K31/44 ,  A61K31/505 ,  C07C235/44 ,  C07C255/54

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, X, m, R2, Y, R3, Z, n, R4, A and B are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

公开(公告)号：US20190010129A1

公开(公告)日：2019-01-10

申请号：US15999570

申请日：2018-08-20

Applicant: Takeda Pharmaceutical Company Limited

Inventor： William Buffham ,  Hannah Canning ,  Richard Davenport ,  William Farnaby ,  Stephen Mack ,  Alka Parmar ,  Susanne Wright

IPC: C07D239/34 ,  C07C255/54 ,  A61K31/44 ,  A61K31/505 ,  C07C235/44 ,  C07D213/81 ,  A61K31/277 ,  C07D213/78 ,  C07C235/46 ,  C07C235/52 ,  A61K31/195

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, formula (I) wherein R1, X, m, R2, Y, R3, Z, n, R4, A and B are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

公开(公告)号：US10059713B2

公开(公告)日：2018-08-28

申请号：US15320887

申请日：2015-06-24

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Gregory Barker ,  Richard Davenport ,  Robert Downham ,  William Farnaby ,  Anne Goldby ,  Duncan Hannah ,  David Harrison ,  Henriette Willems

IPC: C07D487/04 ,  A61K31/519 ,  C07D519/00 ,  C07D471/04 ,  A61K31/437 ,  A61K45/06 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/553

Abstract: The present invention provides compounds of formula (I) (Formula (I)) and pharmaceutically acceptable salts thereof, wherein Q, X % X4, X5 X6, X7, R1, R2, R3 and R8 are as defined in the specification, processes for the preparation of such compounds, pharmaceutical compositions containing them and the use of such compounds in therapy.

公开(公告)号：US09750748B2

公开(公告)日：2017-09-05

申请号：US14652484

申请日：2013-12-17

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： William Farnaby ,  Charlotte Fieldhouse ,  Katherine Hazel ,  Catrina Kerr ,  Natasha Kinsella ,  David Livermore ,  Kevin Merchant ,  David Miller

IPC: A61K31/55 ,  C07D405/04 ,  A61K31/501 ,  C07D403/04 ,  C07D237/20 ,  C07D401/04 ,  A61K45/06 ,  A61K31/50 ,  C07D237/16 ,  C07D237/22 ,  A61K31/277 ,  A61K31/496 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/554 ,  A61K33/00

CPC classification number: A61K31/55 ,  A61K31/277 ,  A61K31/496 ,  A61K31/50 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/554 ,  A61K33/00 ,  A61K45/06 ,  C07D237/16 ,  C07D237/20 ,  C07D237/22 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  A61K2300/00

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.