公开(公告)号：US10202376B2

公开(公告)日：2019-02-12

申请号：US15538297

申请日：2015-12-21

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Eiji Kimura ,  Yuhei Miyanohana ,  Masaki Ogino ,  Yuta Tanaka ,  Makoto Fushimi ,  Tomohiro Okawa ,  Yuki Hanya ,  Tatsuki Koike

IPC: C07D471/04 ,  A61K31/437 ,  C07D487/04 ,  A61P25/00 ,  A61P29/00

Abstract: Provided is a compound having an antagonistic action on an NMDA receptor containing the NR2B subunit, and is useful as a prophylactic or therapeutic agent for major depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, (excluding N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(imidazo[1,2-a]pyridin-5-yl)acetamide) or a salt thereof.

公开(公告)号：US20230037538A1

公开(公告)日：2023-02-09

申请号：US17847456

申请日：2022-06-23

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Dennis Solas ,  Anatoliy Kitaygorodskyy ,  Kumar Paulvannan ,  Vishwanath R. Lingappa ,  Masato Yoshikawa ,  Masahiro Ito ,  Yuta Tanaka ,  Keiko Kakegawa ,  Tomohiro Ohashi ,  Takuto Kojima ,  Akinori Toita ,  Osamu Kubo ,  Fumiaki Kikuchi ,  Florian Pünner ,  Junsi Wang

IPC: C07D217/20 ,  C07D405/06 ,  C07D471/04 ,  C07D401/10 ,  C07D405/10 ,  C07D413/10 ,  C07D405/12 ,  C07D401/12 ,  A61P25/28

Abstract: The present invention relates to compounds expected to be useful in the prevention and/or treatment of diseases such as amyotrophic lateral sclerosis, frontotemporal dementia, chronic traumatic encephalopathy, Alzheimer's disease, frontotemporal lobar degeneration, multisystem proteinopathy and the like, a method for preventing or treating such diseases, and the like.

公开(公告)号：US10519110B2

公开(公告)日：2019-12-31

申请号：US16175144

申请日：2018-10-30

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yasutomi Asano ,  Takuto Kojima ,  Osamu Kurasawa ,  Tzu-Tshin Wong ,  Yasuhiro Hirata ,  Naoki Iwamura ,  Bunnai Saito ,  Yuta Tanaka ,  Ryosuke Arai ,  Shinichi Imamura ,  Kazuko Yonemori ,  Yasufumi Miyamoto ,  Shuji Kitamura ,  Osamu Sano

IPC: C07D211/58 ,  C07F9/6509 ,  C07D401/14 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/452 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/661 ,  A61K33/22 ,  C07D215/42 ,  C07D401/06 ,  C07D401/12 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07F5/02 ,  A61P3/00 ,  A61P35/00 ,  C07B59/00 ,  C07D405/06 ,  C07D413/14

Abstract: The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).

公开(公告)号：US11459325B2

公开(公告)日：2022-10-04

申请号：US16961476

申请日：2019-01-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yuta Tanaka ,  Tomohiro Ohashi ,  Zenichi Ikeda ,  Yuta Tanaka ,  Florian Pünner ,  Takeshi Yamamoto ,  Keiko Kakegawa ,  Fumiaki Kikuchi ,  Nao Morishita ,  Takahito Kasahara ,  Masaki Seto ,  Minoru Nakamura ,  Kazuaki Takami ,  Masataka Murakami ,  Masaki Daini ,  Satoshi Mikami ,  Minoru Sasaki

IPC: C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  A61P25/28

Abstract: The present invention provides a compound having a glucosylceramide lowering action (e.g., promoting glucosylceramide metabolism, inhibition of glucosylceramide synthesis, promoting glucosylceramide catabolism, etc.), which is expected to be useful as an agent for the prophylaxis or treatment of lysosome diseases (e.g., Gaucher's disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US10189785B2

公开(公告)日：2019-01-29

申请号：US15565891

申请日：2016-04-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yasutomi Asano ,  Takuto Kojima ,  Osamu Kurasawa ,  Tzu-Tshin Wong ,  Yasuhiro Hirata ,  Naoki Iwamura ,  Bunnai Saito ,  Yuta Tanaka ,  Ryosuke Arai ,  Shinichi Imamura ,  Kazuko Yonemori ,  Yasufumi Miyamoto ,  Shuji Kitamura ,  Osamu Sano

IPC: C07D211/58 ,  C07D215/42 ,  C07D401/02 ,  C07D413/06 ,  C07D413/14 ,  A61K31/444 ,  A61K31/4709 ,  C07F9/6509 ,  C07D401/14 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/452 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/661 ,  A61K33/22 ,  C07D401/06 ,  C07D401/12 ,  C07D409/12 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07F5/02 ,  A61P3/00 ,  A61P35/00 ,  C07B59/00 ,  C07D405/06

Abstract: The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).