公开(公告)号：US10519110B2

公开(公告)日：2019-12-31

申请号：US16175144

申请日：2018-10-30

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Yasutomi Asano ,  Takuto Kojima ,  Osamu Kurasawa ,  Tzu-Tshin Wong ,  Yasuhiro Hirata ,  Naoki Iwamura ,  Bunnai Saito ,  Yuta Tanaka ,  Ryosuke Arai ,  Shinichi Imamura ,  Kazuko Yonemori ,  Yasufumi Miyamoto ,  Shuji Kitamura ,  Osamu Sano

IPC分类号： C07D211/58 ,  C07F9/6509 ,  C07D401/14 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/452 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/661 ,  A61K33/22 ,  C07D215/42 ,  C07D401/06 ,  C07D401/12 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07F5/02 ,  A61P3/00 ,  A61P35/00 ,  C07B59/00 ,  C07D405/06 ,  C07D413/14

摘要： The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).

公开(公告)号：US09388195B2

公开(公告)日：2016-07-12

申请号：US14566157

申请日：2014-12-10

申请人： Takeda Pharmaceutical Company Limited

发明人： Misaki Homma ,  Toru Miyazaki ,  Yuya Oguro ,  Osamu Kurasawa

IPC分类号： C07D495/04 ,  C07D498/20

CPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D495/04 ,  C07D498/20

摘要： Provided is a compound useful for the prophylaxis or treatment of cancer.The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.

公开(公告)号：US10696651B2

公开(公告)日：2020-06-30

申请号：US16323863

申请日：2017-08-09

申请人： Takeda Pharmaceutical Company Limited

发明人： Jun Fujimoto ,  Xin Liu ,  Osamu Kurasawa ,  Terufumi Takagi ,  Douglas Robert Cary ,  Hiroshi Banno ,  Yasutomi Asano ,  Takuto Kojima

IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D401/14 ,  C07D213/75 ,  C07D405/12 ,  C07D239/42 ,  C07D241/12 ,  C07D471/04 ,  C07D498/04 ,  C07D213/65 ,  A61P35/00 ,  C07D241/20 ,  C07D213/73 ,  A61K31/53 ,  A61K31/505 ,  A61K31/4406 ,  A61K31/444 ,  A61K31/4965 ,  C07D213/68 ,  C07D213/42 ,  A61K31/506 ,  A61K31/497 ,  A61K31/4375 ,  C07D239/20 ,  A61P43/00 ,  A61K31/5383 ,  A61K31/437 ,  A61K31/44 ,  C07D253/06 ,  C07D231/12 ,  C07D239/30 ,  C07D239/34 ,  C07D239/48 ,  C07D253/07 ,  C07D409/12 ,  C07D487/04

摘要： Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

公开(公告)号：US09655900B2

公开(公告)日：2017-05-23

申请号：US15176893

申请日：2016-06-08

申请人： Takeda Pharmaceutical Company Limited

发明人： Misaki Homma ,  Toru Miyazaki ,  Yuya Oguro ,  Osamu Kurasawa

IPC分类号： A61K31/519 ,  C07D495/04 ,  C07D498/20 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55

CPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D495/04 ,  C07D498/20

摘要： Provided is a compound useful for the prophylaxis or treatment of cancer.The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.

公开(公告)号：US10189785B2

公开(公告)日：2019-01-29

申请号：US15565891

申请日：2016-04-19

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Yasutomi Asano ,  Takuto Kojima ,  Osamu Kurasawa ,  Tzu-Tshin Wong ,  Yasuhiro Hirata ,  Naoki Iwamura ,  Bunnai Saito ,  Yuta Tanaka ,  Ryosuke Arai ,  Shinichi Imamura ,  Kazuko Yonemori ,  Yasufumi Miyamoto ,  Shuji Kitamura ,  Osamu Sano

IPC分类号： C07D211/58 ,  C07D215/42 ,  C07D401/02 ,  C07D413/06 ,  C07D413/14 ,  A61K31/444 ,  A61K31/4709 ,  C07F9/6509 ,  C07D401/14 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/452 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/661 ,  A61K33/22 ,  C07D401/06 ,  C07D401/12 ,  C07D409/12 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07F5/02 ,  A61P3/00 ,  A61P35/00 ,  C07B59/00 ,  C07D405/06

摘要： The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).