公开(公告)号：US20190184004A1

公开(公告)日：2019-06-20

申请号：US16322791

申请日：2017-08-03

申请人： TAKEDA VACCINES, INC.

发明人： Jill Ann LIVENGOOD ,  Linda Marie STRANGE ,  Steven Michael ERB

IPC分类号： A61K39/12 ,  C12N7/00

CPC分类号： A61K39/12 ,  A61K2039/5254 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55516 ,  C12N7/00 ,  C12N2770/24034 ,  C12N2770/24134

摘要： Embodiments herein relate to compositions and methods for stabilizing Flaviviruses. In certain embodiments, compositions and methods disclosed herein concern stabilizing live, attenuated or unattenuated (e.g. live whole) flaviviruses. Other embodiments relate to compositions and methods for reducing degradation of live, attenuated or unattenuated flaviviruses. Other embodiments relate to improved formulations for prolonging stabilization of live attenuated or unattenuated Flaviviruses during manufacturing, storage, accelerated storage and transport. Yet other embodiments relate to uses of compositions disclosed herein in kits for transportable applications and methods.

公开(公告)号：US20210121558A1

公开(公告)日：2021-04-29

申请号：US17062923

申请日：2020-10-05

申请人： TAKEDA VACCINES, INC.

发明人： Jill Ann LIVENGOOD ,  Linda Marie STRANGE ,  Steven Michael ERB

IPC分类号： A61K39/12 ,  C12N7/00

摘要： Embodiments herein relate to compositions and methods for stabilizing Flaviviruses. In certain embodiments, compositions and methods disclosed herein concern stabilizing live, attenuated or unattenuated (e.g. live whole) flaviviruses. Other embodiments relate to compositions and methods for reducing degradation of live, attenuated or unattenuated flaviviruses. Other embodiments relate to improved formulations for prolonging stabilization of live attenuated or unattenuated Flaviviruses during manufacturing, storage, accelerated storage and transport. Yet other embodiments relate to uses of compositions disclosed herein in kits for transportable applications and methods.

公开(公告)号：US20240361319A1

公开(公告)日：2024-10-31

申请号：US18687763

申请日：2022-09-09

申请人： TAKEDA VACCINES, INC.

发明人： Betty Elena LUY ,  Shi Hsia HWA ,  Steven Michael ERB ,  Jill A. LIVENGOOD ,  Andrew Montgomery THOMSON

IPC分类号： G01N33/569

CPC分类号： G01N33/56983 ,  G01N2333/185 ,  G01N2469/10

摘要： The present invention provides improved immunofocus assays for determining the virus titer of dengue viruses and the use thereof in the quality control of vaccines based on live attenuated dengue viruses or in the diagnosis of a blood sample from a dengue infected individual.

公开(公告)号：US20230263880A1

公开(公告)日：2023-08-24

申请号：US18113193

申请日：2023-02-23

申请人： TAKEDA VACCINES, INC.

发明人： Jill Ann LIVENGOOD ,  Linda Marie STRANGE ,  Steven Michael ERB

IPC分类号： A61K39/12 ,  C12N7/00

CPC分类号： A61K39/12 ,  C12N7/00 ,  A61K2039/5254

摘要： Embodiments herein relate to compositions and methods for stabilizing Flaviviruses. In certain embodiments, compositions and methods disclosed herein concern stabilizing live, attenuated or unattenuated (e.g. live whole) flaviviruses. Other embodiments relate to compositions and methods for reducing degradation of live, attenuated or unattenuated flaviviruses. Other embodiments relate to improved formulations for prolonging stabilization of live attenuated or unattenuated Flaviviruses during manufacturing, storage, accelerated storage and transport. Yet other embodiments relate to uses of compositions disclosed herein in kits for transportable applications and methods.