公开(公告)号：US12006341B2

公开(公告)日：2024-06-11

申请号：US17702985

申请日：2022-03-24

申请人： TAKEDA VACCINES, INC.

发明人： Joel R. Haynes

IPC分类号： C07K14/005 ,  A61K39/205 ,  C07K1/14 ,  C12N7/00 ,  C12Q1/70 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/205 ,  C07K1/14 ,  C12N7/00 ,  C12Q1/701 ,  A61K2039/5258 ,  C12N2760/20021 ,  C12N2760/20023 ,  C12N2760/20034 ,  C12N2760/20051 ,  C12N2760/20052 ,  C12N2770/16023 ,  C12Q2600/158

摘要： The present disclosure relates to compositions, methods, mixtures, and kits for detecting the presence of, and for removing, a virus from a product produced in an insect cell. The disclosure also relates to proteins, peptides, polypeptides, drug substances, biological products, vaccine antigens, and virus-like particles that are produced in an insect cell and that are free or substantially free of a virus. The disclosure also relates to compositions, methods, assays, and kits for detecting a rhabdovirus in a sample.

公开(公告)号：US11975062B2

公开(公告)日：2024-05-07

申请号：US16768499

申请日：2018-11-30

申请人： Takeda Vaccines, Inc.

发明人： Jill A. Livengood ,  Hansi Dean ,  Htay Htay Han ,  Raman Rao ,  Jackie Marks ,  Gary Dubin ,  Laurence De Moerlooze ,  Hetal Patel ,  Asae Shintani ,  Holli Giebler ,  James Gifford ,  Mark Lyons ,  Sushma Kommareddy ,  Tatsuki Satou

IPC分类号： A61K39/12 ,  A61P31/14 ,  C12N7/00 ,  C12Q1/22 ,  A61K39/00 ,  G01N30/74

CPC分类号： A61K39/12 ,  A61P31/14 ,  C12N7/00 ,  C12Q1/22 ,  A61K2039/5252 ,  A61K2039/545 ,  C12N2770/24134 ,  C12N2770/24151 ,  C12N2770/24163 ,  G01N30/74

摘要： The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof.

公开(公告)号：US20230338503A1

公开(公告)日：2023-10-26

申请号：US18322679

申请日：2023-05-24

申请人： Takeda Vaccines, Inc.

发明人： Charles RICHARDSON ,  Thomas R. FOUBERT ,  Robert F. BARGATZE ,  Paul MENDELMAN

IPC分类号： A61K39/12 ,  A61K39/125 ,  A61K39/39

CPC分类号： A61K39/12 ,  A61K39/125 ,  A61K39/39 ,  A61K2039/55505

摘要： The present invention relates to single dose parenteral vaccine compositions comprising mixtures of monovalent Norovirus virus-like particles. Methods of conferring protective immunity against Norovirus infections in a human subject by administering such compositions are also disclosed.

公开(公告)号：US20220211836A1

公开(公告)日：2022-07-07

申请号：US17609217

申请日：2020-04-08

申请人： Takeda Vaccines, Inc.

发明人： Michael JOHNSON ,  Sushma KOMMAREDDY

IPC分类号： A61K39/12 ,  A61K47/10 ,  A61K47/26 ,  A61K47/02

摘要： The present invention relates to a liquid inactivated virus composition comprising: an inactivated whole Zika virus, at least one pharmaceutically acceptable buffer with a concentration of at least about 6.5 mM, and optionally a polyol, wherein said at least one pharmaceutically acceptable buffer does not comprise phosphate ions and vaccines derived therefrom.

公开(公告)号：US11286282B2

公开(公告)日：2022-03-29

申请号：US16662784

申请日：2019-10-24

申请人： TAKEDA VACCINES, INC.

发明人： Joel R. Haynes

IPC分类号： C07K14/005 ,  C12N7/00 ,  C07K1/14 ,  C12Q1/70 ,  A61K39/205 ,  A61K39/00

摘要： The present disclosure relates to compositions, methods, mixtures, and kits for detecting the presence of, and for removing, a virus from a product produced in an insect cell. The disclosure also relates to proteins, peptides, polypeptides, drug substances, biological products, vaccine antigens, and virus-like particles that are produced in an insect cell and that are free or substantially free of a virus. The disclosure also relates to compositions, methods, assays, and kits for detecting a rhabdovirus in a sample.

公开(公告)号：US20210403879A1

公开(公告)日：2021-12-30

申请号：US16768550

申请日：2018-11-30

申请人： TAKEDA VACCINES, INC.

发明人： Jill A LIVENGOOD ,  Holli GIEBLER ,  Hansi DEAN ,  Tatsuki SATOU ,  Raman RAO ,  Jackie MARKS ,  Mark LYONS ,  Asae SHINTANI ,  James GIFFORD ,  Nao OGASAWARA ,  Masafumi MISAKI ,  Satoshi ADACHI

IPC分类号： C12N7/00 ,  A61K39/12 ,  A61P31/14 ,  C12Q1/22

摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation and to a method for determining the residual formaldehyde content in a pharmaceutical composition comprising an inactivated virus.

公开(公告)号：US10792353B2

公开(公告)日：2020-10-06

申请号：US16213297

申请日：2018-12-07

申请人： TAKEDA VACCINES, INC.

发明人： Thomas S. Vedvick ,  Bryan Steadman ,  Charles Richardson ,  Thomas R. Foubert ,  Charles R. Petrie

IPC分类号： A61K39/12 ,  C12N7/00 ,  C07K1/18 ,  C07K14/005

摘要： Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.

公开(公告)号：US20200230230A1

公开(公告)日：2020-07-23

申请号：US16561953

申请日：2019-09-05

申请人： Takeda Vaccines, Inc.

发明人： Derek WALLACE ,  Inge LEFEVRE

IPC分类号： A61K39/295

摘要： The invention relates to a unit dose of a dengue vaccine composition and methods and uses for preventing dengue disease and methods for stimulating an immune response to all four dengue virus serotypes in a subject or subject population. The unit dose of a dengue vaccine composition includes constructs of each dengue serotype, such as TDV-1, TDV-2, TDV-3 and TDV-4, at various concentrations in order to improve protection from dengue infection.

公开(公告)号：US10512682B2

公开(公告)日：2019-12-24

申请号：US15994887

申请日：2018-05-31

申请人： TAKEDA VACCINES, INC.

发明人： Charles Richardson ,  Thomas S. Vedvick ,  Thomas R. Foubert ,  William T. Tino

IPC分类号： A61K39/12 ,  A61K39/125 ,  C07K16/10 ,  A61K39/39 ,  C12N7/00 ,  A61K39/00

摘要： The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.

公开(公告)号：US20190381163A1

公开(公告)日：2019-12-19

申请号：US16093385

申请日：2017-04-13

申请人： TAKEDA VACCINES, INC.

发明人： Derek WALLACE ,  John BOSLEGO

IPC分类号： A61K39/12

摘要： Embodiments herein concern compositions, methods, and uses for inducing an immune response to all four dengue virus serotypes in a child or young adult from about 1 year to about 20 years of age. Some embodiments concern compositions that can include dengue virus chimeras that, either alone or in combination with other constructs, can be used in vaccine compositions against all four dengue virus serotypes. Compositions can include constructs of more than one serotypes of dengue virus, such as dengue-1 (DEN-1) virus, dengue-2 (DEN-2) virus, dengue-3 (DEN-3) virus and/or dengue-4 (DEN-4) virus, at various concentrations or ratios to improve protection from infection in children and young adults. In certain embodiments, viruses of the formulations are limited to dengue virus serotypes. Other embodiments concern methods of administering immunogenic compositions against dengue virus that can include chimeric dengue constructs and live, attenuated dengue viruses using single, dual or other regimens.