公开(公告)号：US20240361319A1

公开(公告)日：2024-10-31

申请号：US18687763

申请日：2022-09-09

申请人： TAKEDA VACCINES, INC.

发明人： Betty Elena LUY ,  Shi Hsia HWA ,  Steven Michael ERB ,  Jill A. LIVENGOOD ,  Andrew Montgomery THOMSON

IPC分类号： G01N33/569

CPC分类号： G01N33/56983 ,  G01N2333/185 ,  G01N2469/10

摘要： The present invention provides improved immunofocus assays for determining the virus titer of dengue viruses and the use thereof in the quality control of vaccines based on live attenuated dengue viruses or in the diagnosis of a blood sample from a dengue infected individual.

公开(公告)号：US20230145065A1

公开(公告)日：2023-05-11

申请号：US17931887

申请日：2022-09-13

申请人： TAKEDA VACCINES, INC.

发明人： Jill A. LIVENGOOD ,  Holli Giebler ,  Hansi Dean ,  Tatsuki Satou ,  Raman Rao ,  Jackie Marks ,  Mark Lyons ,  Asae Shintani ,  James Gifford ,  Sushma Kommareddy

IPC分类号： A61K39/12 ,  A61P31/14 ,  C12N7/00 ,  A61K9/00 ,  A61K39/39

CPC分类号： A61K39/12 ,  A61P31/14 ,  C12N7/00 ,  A61K9/0019 ,  A61K39/39 ,  A61K2039/5252

摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.

公开(公告)号：US20210177959A1

公开(公告)日：2021-06-17

申请号：US16761340

申请日：2018-11-05

申请人： TAKEDA VACCINES, INC.

发明人： Jill A. LIVENGOOD ,  Holli GIEBLER ,  Hansi DEAN ,  Tatsuki SATOU ,  Raman RAO ,  Jackie MARKS ,  Mark LYONS ,  Asae SHINTANI ,  Jamie GIFFORD

IPC分类号： A61K39/12 ,  C12N7/00

摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.

公开(公告)号：US20240285747A1

公开(公告)日：2024-08-29

申请号：US18242025

申请日：2023-09-05

申请人： Takeda Vaccines, Inc.

发明人： Jill A. LIVENGOOD ,  HANSI DEAN ,  Htay Htay HAN ,  Raman RAO ,  Jackie MARKS ,  Gary DUBIN ,  Laurence DE MOERLOOZE ,  Hetal PATEL ,  Asae SHINTANI ,  Holli GIEBLER ,  James GIFFORD ,  Mark LYONS ,  Sushma KOMMAREDDY ,  Tatsuki SATOU

IPC分类号： A61K39/12 ,  A61K39/00 ,  A61P31/14 ,  C12N7/00 ,  C12Q1/22 ,  G01N30/74

CPC分类号： A61K39/12 ,  A61P31/14 ,  C12N7/00 ,  C12Q1/22 ,  A61K2039/5252 ,  A61K2039/545 ,  C12N2770/24134 ,  C12N2770/24151 ,  C12N2770/24163 ,  G01N30/74

摘要： The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof.

公开(公告)号：US20230398199A9

公开(公告)日：2023-12-14

申请号：US16768499

申请日：2018-11-30

申请人： TAKEDA VACCINES, INC.

发明人： Jill A. LIVENGOOD ,  Hansi DEAN ,  Htay Htay HAN ,  Raman RAO ,  Jackie MARKS ,  Gary DUBIN ,  Laurence DE MOERLOOZE ,  Hetal PATEL ,  Asae SHINTANI ,  Holli GIEBLER ,  James GIFFORD ,  Mark LYONS ,  Sushma KOMMAREDDY ,  Tatsuki SATOU

IPC分类号： A61K39/12 ,  A61P31/14

CPC分类号： A61K39/12 ,  A61P31/14 ,  A61K2039/545

摘要： The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof

公开(公告)号：US20230181682A1

公开(公告)日：2023-06-15

申请号：US18064775

申请日：2022-12-12

申请人： TAKEDA VACCINES, INC. ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

发明人： Dan T. STINCHCOMB ,  Claire KINNEY ,  Richard M. KINNEY ,  Jill A. LIVENGOOD

IPC分类号： A61K38/16 ,  A61K31/7048 ,  A61K39/12 ,  A61K31/713 ,  C07K14/005 ,  C07K14/18 ,  C07K19/00 ,  C12N15/09 ,  C12N15/861

CPC分类号： A61K38/162 ,  A61K31/7048 ,  A61K39/12 ,  A61K31/713 ,  C07K14/005 ,  C07K14/1825 ,  C07K19/00 ,  C12N15/09 ,  C12N15/8613 ,  A61K2039/5254

摘要： Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition. In certain embodiments, compositions can include constructs of one or more serotypes of dengue virus, such as dengue-1 (DEN-1) virus, dengue-2 (DEN-2) virus, dengue-3 (DEN-3) or dengue-4 (DEN-4) virus constructs. In other embodiments, constructs disclosed herein can be combined in a composition to generate a vaccine against more one or more dengue virus constructs that may or may not be subsequently passaged in mammalian cells.

公开(公告)号：US20220332800A1

公开(公告)日：2022-10-20

申请号：US17295770

申请日：2019-09-20

申请人： Takeda Vaccines, Inc.

发明人： Subash C. DAS ,  Isamu TSUJI ,  Jill A. LIVENGOOD ,  Hansi DEAN

IPC分类号： C07K16/10 ,  A61K39/42 ,  A61K45/06 ,  G01N33/569

摘要： The present invention provides isolated monoclonal antibodies, or antigen-binding portions thereof, that bind to ZIKV glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies, or antigen-binding portions thereof, according to the present invention are useful for inhibiting or neutralizing ZIKV activity, thus providing a means of treating or preventing ZIKV infection in humans. The antibodies, or antigen-binding portions thereof, according to the present invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.

公开(公告)号：US20240325518A1

公开(公告)日：2024-10-03

申请号：US18639558

申请日：2024-04-18

申请人： Takeda Vaccines, Inc.

发明人： Jill A. LIVENGOOD ,  Holli GIEBLER ,  Hansi DEAN ,  Tatsuki SATOU ,  Raman RAO ,  Jackie MARKS ,  Mark LYONS ,  Asae SHINTANI ,  James GIFFORD ,  Sushma Kommareddy

IPC分类号： A61K39/12 ,  A61K9/00 ,  A61K39/00 ,  A61K39/39 ,  A61P31/14 ,  C12N7/00

CPC分类号： A61K39/12 ,  A61K9/0019 ,  A61K39/39 ,  A61P31/14 ,  C12N7/00 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55505 ,  C12N2770/24034 ,  C12N2770/24071 ,  C12N2770/24134 ,  C12N2770/24151 ,  C12N2770/24163 ,  C12N2770/24164

摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.

公开(公告)号：US20230414743A1

公开(公告)日：2023-12-28

申请号：US18336439

申请日：2023-06-16

申请人： TAKEDA VACCINES, INC.

发明人： Jill A. LIVENGOOD ,  Hansi DEAN ,  Htay Htay HAN ,  Raman RAO ,  Jackie MARKS ,  Gary DUBIN ,  Laurence DE MOERLOOZE ,  Hetal PATEL ,  Sushma KOMMAREDDY

IPC分类号： A61K39/12 ,  A61P31/14 ,  C12N7/00 ,  A61K9/00 ,  A61K39/39

CPC分类号： A61K39/12 ,  A61P31/14 ,  C12N7/00 ,  A61K9/0019 ,  A61K39/39 ,  A61K2039/5252

摘要： The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof.

公开(公告)号：US20220062375A1

公开(公告)日：2022-03-03

申请号：US17478537

申请日：2021-09-17

申请人： TAKEDA VACCINES, INC. ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT

发明人： Dan T. STINCHCOMB ,  Claire KINNEY ,  Richard M. KINNEY ,  Jill A. LIVENGOOD

IPC分类号： A61K38/16 ,  A61K31/7048 ,  A61K39/12 ,  A61K31/713 ,  C07K14/005 ,  C07K14/18 ,  C07K19/00 ,  C12N15/09 ,  C12N15/861

摘要： Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition. In certain embodiments, compositions can include constructs of one or more serotypes of dengue virus, such as dengue-1 (DEN-1) virus, dengue-2 (DEN-2) virus, dengue-3 (DEN-3) or dengue-4 (DEN-4) virus constructs. In other embodiments, constructs disclosed herein can be combined in a composition to generate a vaccine against more one or more dengue virus constructs that may or may not be subsequently passaged in mammalian cells.