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公开(公告)号：US20220168228A1
公开(公告)日：2022-06-02
申请号：US17437442
申请日：2020-03-19
发明人： Andrew Wise , Yutian Ma , Frank Caruso , Mattias Björnmalm
摘要： The present disclosure relates to supraparticles loaded with high levels of payload and having controlled payload release profiles. In particular, supraparticles made of mesoporous silica nanoparticles and elecrosprayed with alginic acid which is then coated or formulated with biodegradable materials is disclosed. Such supraparticles may be used in a range of therapeutic applications.
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公开(公告)号：US20220362337A1
公开(公告)日：2022-11-17
申请号：US17824654
申请日：2022-05-25
发明人： Andrew Wise , Robert K. Shepherd , Frank Caruso
IPC分类号： A61K38/18 , A61P27/16 , A61K9/00 , A61K9/16 , A61K31/573 , A61K38/20 , A61K9/06 , A61K9/51 , A61K47/36
摘要： The present invention relates to methods of treating an auditory disorder. In particular, the present invention relates to treating an auditory disorder using supraparticles comprising a therapeutic payload.
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公开(公告)号：US20200000879A1
公开(公告)日：2020-01-02
申请号：US16459263
申请日：2019-07-01
发明人： Andrew Wise , Robert K. Shepherd , Frank Caruso
摘要： The present invention relates to methods of treating an auditory disorder. In particular, the present invention relates to treating an auditory disorder using supraparticles comprising a therapeutic payload.
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公开(公告)号：US12048733B2
公开(公告)日：2024-07-30
申请号：US17824654
申请日：2022-05-25
发明人： Andrew Wise , Robert K. Shepherd , Frank Caruso
IPC分类号： A61K38/18 , A61K9/00 , A61K9/06 , A61K9/16 , A61K9/51 , A61K31/573 , A61K38/20 , A61K47/36 , A61P27/16 , B82Y5/00
CPC分类号： A61K38/185 , A61K9/0024 , A61K9/0046 , A61K9/06 , A61K9/1611 , A61K9/1652 , A61K9/5115 , A61K9/5161 , A61K9/5192 , A61K31/573 , A61K38/2073 , A61K47/36 , A61P27/16 , B82Y5/00
摘要： The present invention relates to methods of treating an auditory disorder. In particular, the present invention relates to treating an auditory disorder using supraparticles comprising a therapeutic payload.
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公开(公告)号：US20230135903A1
公开(公告)日：2023-05-04
申请号：US18086412
申请日：2022-12-21
发明人： Andrew Wise , Frank Caruso , Mattias Bjornmalm , Yutian Ma
IPC分类号： A61K38/18 , A61P27/16 , A61K9/00 , A61K9/16 , A61K31/573 , A61K38/20 , A61K9/06 , A61K9/51 , A61K47/36
摘要： The present disclosure relates to improved supraparticles loaded with high levels of payload and methods for their production. Such supraparticles may be used in a range of therapeutic applications, for example, to improve growth or survival of cells and/or treat disease.
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公开(公告)号：US11369661B2
公开(公告)日：2022-06-28
申请号：US16459263
申请日：2019-07-01
发明人： Andrew Wise , Robert K. Shepherd , Frank Caruso
IPC分类号： A61K38/18 , A61P27/16 , A61K9/00 , A61K9/16 , A61K31/573 , A61K38/20 , A61K9/06 , A61K9/51 , A61K47/36 , B82Y5/00
摘要： The present invention relates to methods of treating an auditory disorder. In particular, the present invention relates to treating an auditory disorder using supraparticles comprising a therapeutic payload.
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公开(公告)号：US20200253865A1
公开(公告)日：2020-08-13
申请号：US16648858
申请日：2018-09-20
发明人： Andrew Wise , Frank Caruso , Mattias Bjornmalm , Yutian Ma
摘要： The present disclosure relates to improved supraparticles loaded with high levels of payload and methods for their production. Such supraparticles may be used in a range of therapeutic applications, for example, to improve growth or survival of cells and/or treat disease.
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公开(公告)号：US20220257925A1
公开(公告)日：2022-08-18
申请号：US17622511
申请日：2020-06-26
发明人： Rachael Scott-Young , James Fallon , Andrew Wise , Alexander Thompson , Paul Randall Stoddart , William Lloyd Hart , Karina Brady
摘要： Disclosed is a method for stimulating neural tissue, where the neural tissue includes one or more neurons genetically modified to express a light-sensitive protein. The method comprises applying a light stimulus and an electrical stimulus to the neural tissue, thereby triggering membrane depolarisation in at least one of the neurons. Also disclosed is an apparatus for applying the disclosed method. The apparatus includes a light-stimulation device for selectively applying a light stimulus and an electrical-stimulation device for selectively applying an electrical stimulus to the neural tissue.
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