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公开(公告)号：US11787769B2
公开(公告)日：2023-10-17
申请号：US17735235
申请日：2022-05-03
发明人： Lijun Rong , Irina Gaisina , Gregory R. Thatcher , Norton Peet
IPC分类号： C07D215/58 , A61P31/16 , A61K31/47 , A61K45/06
CPC分类号： C07D215/58 , A61K31/47 , A61K45/06 , A61P31/16
摘要： Vaccination is the most prevalent prophylactic means for controlling seasonal influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Therefore, new therapeutic options are needed for acute treatment of influenza infections to control this virus and prevent epidemic/pandemic situations from developing. Described herein are fast-acting, orally active acylated amino-substituted heterocyclyl compounds effective to control this virus. In one aspect, described herein is a method of treating an influenza infection in a subject comprising administering to the subject the compounds described herein.
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公开(公告)号：US11739064B2
公开(公告)日：2023-08-29
申请号：US17099360
申请日：2020-11-16
发明人： Alan Kozikowski , Irina Gaisina
IPC分类号： A61K31/4155 , C07D261/10 , A61K45/06 , C07D413/06 , C07D413/12 , C07D417/12 , A61K31/422 , C07D261/18 , A61K31/42 , A61K31/427 , A61P35/00
CPC分类号： C07D261/10 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K45/06 , A61P35/00 , C07D261/18 , C07D413/06 , C07D413/12 , C07D417/12 , Y02A50/30 , A61K31/422 , A61K2300/00 , A61K31/42 , A61K2300/00 , A61K31/4155 , A61K2300/00 , A61K31/427 , A61K2300/00
摘要： Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.
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公开(公告)号：US20210139438A1
公开(公告)日：2021-05-13
申请号：US17099360
申请日：2020-11-16
发明人： Alan Kozikowski , Irina Gaisina
IPC分类号： C07D261/10 , A61K45/06 , C07D413/06 , C07D413/12 , C07D417/12 , A61K31/422 , C07D261/18 , A61K31/42 , A61K31/427 , A61K31/4155 , A61P35/00
摘要： Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed
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公开(公告)号：US20190023670A1
公开(公告)日：2019-01-24
申请号：US15756086
申请日：2016-08-31
发明人： Alan Kozikowski , Irina Gaisina
IPC分类号： C07D261/10 , C07D413/12 , C07D413/06 , C07D417/12 , A61P35/00
摘要： Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed
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公开(公告)号：US10934255B2
公开(公告)日：2021-03-02
申请号：US16603266
申请日：2018-04-25
发明人： Irina Gaisina , Alan Kozikowski
IPC分类号： C07D209/30 , A61K51/04 , A61K45/06
摘要： Compounds that inhibit histone (HDACI) and/or activate Nrf2 and HIF, and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC and/or activation of Nrf2 and HIF provide a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.
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公开(公告)号：US20200039933A1
公开(公告)日：2020-02-06
申请号：US16603266
申请日：2018-04-25
发明人： Irina Gaisina , Alan Kozikowski
IPC分类号： C07D209/30 , A61K51/04
摘要： Compounds that inhibit histone (HDACI) and/or activate Nrf2 and HIF, and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC and/or activation of Nrf2 and HIF provide a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.
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公开(公告)号：US20220267275A1
公开(公告)日：2022-08-25
申请号：US17735235
申请日：2022-05-03
发明人： Lijun Rong , Irina Gaisina , Gregory R. Thatcher , Norton Peet
IPC分类号： C07D215/58 , A61K31/47 , A61K45/06 , A61P31/16
摘要： Vaccination is the most prevalent prophylactic means for controlling seasonal influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Therefore, new therapeutic options are needed for acute treatment of influenza infections to control this virus and prevent epidemic/pandemic situations from developing. Described herein are fast-acting, orally active acylated amino-substituted heterocyclyl compounds effective to control this virus. In one aspect, described herein is a method of treating an influenza infection in a subject comprising administering to the subject the compounds described herein.
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8.发明授权公开(公告)号：US10456394B2
公开(公告)日：2019-10-29
申请号：US15998610
申请日：2017-02-15
发明人： Alan Kozikowski , Sida Shen , Joel Bergman , Irina Gaisina
IPC分类号： C07D215/08 , C07D241/44 , C07D279/16 , A61K31/498 , A61K31/5415 , A61K31/47 , A61P35/00 , A61P37/00 , A61P25/28
摘要： Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an autoimmune disease, autism, and inflammation, also are disclosed.
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