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公开(公告)号:US11260105B2
公开(公告)日:2022-03-01
申请号:US16895161
申请日:2020-06-08
发明人: Terry Vanden Hoek , Xiangdong Zhu , Jing Li
IPC分类号: A61K38/17 , G01N33/68 , A61P9/04 , A61K31/455 , C40B40/08 , C07K16/00 , C12N5/10 , C12N9/16 , C12N9/12
摘要: Modified peptides based on C-terminal PDZ binding domains of PTEN and PHLPP, or PDK1 interacting fragment of PKN2 are described as are methods of using the modified peptides for blocking the activity of PTEN, PHLPP and PKN2 and treating sudden cardiac arrest. A method for guiding treatment of cardiac arrest based on sorbitol or taurine levels is also provided.
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公开(公告)号:US10688153B2
公开(公告)日:2020-06-23
申请号:US15769132
申请日:2016-11-07
发明人: Terry Vanden Hoek , Xiangdong Zhu , Jing Li
IPC分类号: A61K38/16 , A61K38/10 , A61K38/08 , A61K38/00 , A61P9/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/04 , A61K38/17 , C40B40/08 , G01N33/68 , C12N5/10 , C12N9/16 , C12N9/12 , A61P9/04 , A61K31/455
摘要: Modified peptides based on C-terminal PDZ binding domains of PTEN and PHLPP, or PDK1 interacting fragment of PKN2 are described as are methods of using the modified peptides for blocking the activity of PTEN, PHLPP and PKN2 and treating sudden cardiac arrest. A method for guiding treatment of cardiac arrest based on sorbitol or taurine levels is also provided.
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公开(公告)号:US20180296640A1
公开(公告)日:2018-10-18
申请号:US15769132
申请日:2016-11-07
发明人: Terry Vanden Hoek , Xiangdong Zhu , Jing Li
CPC分类号: A61K38/1761 , A61K31/455 , A61K2300/00 , A61P9/04 , C07K16/00 , C07K2319/00 , C12N5/10 , C12N9/1205 , C12N9/16 , C12Y301/03016 , C40B40/08 , G01N33/6893 , G01N2800/325 , G01N2800/52
摘要: Modified peptides based on C-terminal PDZ binding domains of PTEN and PHLPP, or PDK1 interacting fragment of PKN2 are described as are methods of using the modified peptides for blocking the activity of PTEN, PHLPP and PKN2 and treating sudden cardiac arrest. A method for guiding treatment of cardiac arrest based on sorbitol or taurine levels is also provided.
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公开(公告)号:US20200297813A1
公开(公告)日:2020-09-24
申请号:US16895161
申请日:2020-06-08
发明人: Terry Vanden Hoek , Xiangdong Zhu , Jing Li
摘要: Modified peptides based on C-terminal PDZ binding domains of PTEN and PHLPP, or PDK1 interacting fragment of PKN2 are described as are methods of using the modified peptides for blocking the activity of PTEN, PHLPP and PKN2 and treating sudden cardiac arrest. A method for guiding treatment of cardiac arrest based on sorbitol or taurine levels is also provided.
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