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公开(公告)号：US11504340B2
公开(公告)日：2022-11-22
申请号：US16612181
申请日：2018-05-10
摘要： The invention provides methods of making microparticle and nanoparticle ocular implants from a compositions comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent.
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公开(公告)号：US20210378979A1
公开(公告)日：2021-12-09
申请号：US16612181
申请日：2018-05-10
摘要： The invention provides methods of making microparticle and nanoparticle ocular implants from a compositions comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent.
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公开(公告)号：US20180244927A1
公开(公告)日：2018-08-30
申请号：US15556255
申请日：2016-03-04
发明人： Colin McCoy , Sean Gorman , David Jones , Daniel Corbett , Nicola Irwin
CPC分类号： C09D4/06 , A61L27/34 , A61L29/041 , A61L29/085 , A61L29/14 , A61L31/10 , A61L2400/10 , A61L2420/02 , A61L2420/06 , C09D5/00 , C08F271/02 , C08L39/06 , C08L51/00
摘要： The present invention provides a polymerizable coating composition comprising: (i) 1-vinyl-2-pyrrolidinone (NVP) and 2-hydroxyethylmethacrylate (2-HEMA) for forming a copolymer; (ii) a poly(vinyl pyrrolidone) (PVP) polymer having a molecular weight of at least 500,000 g·mol−1; (iii) a co-polymerizable crosslinker for crosslinking the 1-vinyl-2-pyrrolidinone (NVP) and the 2-hydroxyethylmethacrylate (2-HEMA); (iv) a co-polymerizable initiator for initiating co-polymerisation of the 1-vinyl-2-pyrrolidinone (NVP) and 2-hydroxyethylmethacrylate (2-HEMA); (v) a surfactant selected from non-ionic triblock copolymers of ethylene oxide/propylene oxide, nonionic triblock copolymers of poly(propylene oxide) (PPO) and poly(ethylene oxide) (PEO), tetrablock copolymers of PPO and PEO; Triton X-100 and derivatives thereof, polyethylene glycols and derivatives thereof, PEO derivatives of sorbitan monolaurate, and combinations of any two or more thereof; (vi) a solvent, wherein a vinyl component is 1-vinyl-2-pyrrolidinone for forming the copolymer and the PVP polymer, and an acrylate component is 2-hydroxyethyl methacrylate for forming the copolymer; wherein the vinyl and acrylate components are present at a molar ratio of between 10:1 and 1:10; and wherein 20-80% (w/w) of the vinyl component is PVP polymer.
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