公开(公告)号：US08654441B2

公开(公告)日：2014-02-18

申请号：US13668239

申请日：2012-11-03

Applicant: The Regents of the University of California

Inventor： Bahram Jalali ,  Ali Motafakker-Fard

IPC: G02B21/00

CPC classification number: G01J1/0411 ,  G02B21/002 ,  G02B21/14 ,  H04N5/14

Abstract: We describe methods and apparatus for high-speed high-contrast imaging one-, two- and three-dimensional imaging enabled by differential interference contrast time encoded amplified microscopy of transparent media without the need for chemical staining, that are suitable for a broad range of applications from semiconductor process monitoring to blood screening. Our methods and apparatus build on a unique combination of serial time-encoded amplified microscopy (STEAM) and differential interference contrast (DIC) microscopy. These methods and apparatus are ideally suited for identification of rare diseased cells in a large population of healthy cells and have the potential to revolutionize blood analysis and pathology including identification of cancer cells, such as Circulating Tumor Cells (CTC) in early stage disease.

Abstract translation: 我们描述了用于高速高对比度成像的一维，二维和三维成像的方法和装置，其通过差示干涉对比度时间编码的透明介质的放大显微镜而不需要化学染色，其适用于广泛的 从半导体工艺监测到血液筛查的应用。 我们的方法和设备基于串行时间编码放大显微镜（STEAM）和微分干涉对比（DIC）显微镜的独特组合。 这些方法和装置非常适用于大量健康细胞中罕见病变细胞的鉴定，并具有革命性的血液分析和病理学的潜力，包括癌症细胞的鉴定，如早期疾病中的循环肿瘤细胞（CTC）。

公开(公告)号：US20140067300A1

公开(公告)日：2014-03-06

申请号：US13855564

申请日：2013-04-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Shalabh Gupta ,  Bahram Jalali ,  Ali Motafakker-Fard

IPC: G01R13/02

CPC classification number: G01R13/0218 ,  G02F1/225 ,  G02F7/00 ,  H03M1/1042 ,  H03M1/12

Abstract: A time-stretched enhanced recording scope (TiSER) is described using time stretch analog-to-digital conversion in a real-time burst mode. A chirped optical signal is modulated in response to receiving segments of an input signal. The optical signal with its modulated input signal, is stretched through an optical medium and digitized to represent the waveform segment. TiSER provides ultra-fast real-time sampling within short segment bursts of the original input signal while providing an ability to detect non-repetitive events. Methods and apparatus are also described for providing real-time information about inter-symbol information (ISI), rapidly determining bit-error rates (BER), performing time-domain reflectometry (TDR), generating eye diagrams for serial data, facilitating digital correction of data, clock recovery, optical carrier phase recovery, and otherwise increasing the speed and/or accuracy of a diverse range of high-speed signal measurement and processing activities.

Abstract translation: 使用实时突发模式中的时间拉伸模数转换来描述时间延长的增强记录范围（TiSER）。 响应于输入信号的接收段调制啁啾光信号。 具有调制输入信号的光信号通过光学介质被拉伸并数字化以表示波形段。 TiSER在原始输入信号的短片段突发中提供超快速实时采样，同时提供检测非重复事件的能力。 还描述了用于提供关于符号间信息（ISI），快速确定误码率（BER），执行时域反射计（TDR），生成串行数据眼图，促进数字校正的实时信息的方法和装置 的数据，时钟恢复，光载波相位恢复，否则增加了各种范围的高速信号测量和处理活动的速度和/或精度。

公开(公告)号：US08686712B2

公开(公告)日：2014-04-01

申请号：US13855564

申请日：2013-04-02

Applicant: The Regents of the University of California

Inventor： Shalabh Gupta ,  Bahram Jalali ,  Ali Motafakker-Fard

IPC: G01R31/00

CPC classification number: G01R13/0218 ,  G02F1/225 ,  G02F7/00 ,  H03M1/1042 ,  H03M1/12

Abstract: A time-stretched enhanced recording scope (TiSER) is described using time stretch analog-to-digital conversion in a real-time burst mode. A chirped optical signal is modulated in response to receiving segments of an input signal. The optical signal with its modulated input signal, is stretched through an optical medium and digitized to represent the waveform segment. TiSER provides ultra-fast real-time sampling within short segment bursts of the original input signal while providing an ability to detect non-repetitive events. Methods and apparatus are also described for providing real-time information about inter-symbol information (ISI), rapidly determining bit-error rates (BER), performing time-domain reflectometry (TDR), generating eye diagrams for serial data, facilitating digital correction of data, clock recovery, optical carrier phase recovery, and otherwise increasing the speed and/or accuracy of a diverse range of high-speed signal measurement and processing activities.

Abstract translation: 使用实时突发模式中的时间拉伸模数转换来描述时间延长的增强记录范围（TiSER）。 响应于输入信号的接收段调制啁啾光信号。 具有调制输入信号的光信号通过光学介质被拉伸并数字化以表示波形段。 TiSER在原始输入信号的短片段突发中提供超快速实时采样，同时提供检测非重复事件的能力。 还描述了用于提供关于符号间信息（ISI），快速确定误码率（BER），执行时域反射计（TDR），生成串行数据眼图，促进数字校正的实时信息的方法和装置 的数据，时钟恢复，光载波相位恢复，否则增加了各种范围的高速信号测量和处理活动的速度和/或精度。