公开(公告)号：US10041883B2

公开(公告)日：2018-08-07

申请号：US14472735

申请日：2014-08-29

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Warren S. Grundfest ,  Oscar M. Stafsudd ,  Pei-Chi Jiang ,  Asael Papour ,  Zachary Deis Taylor ,  Maie St. John

IPC: G01J1/58 ,  G01N21/64 ,  G02B21/16

Abstract: A time-resolved fluorescence imaging (TRFI) system that images a target medium without lifetime fitting. Instead of extracting the lifetime precisely, the system images the fluorophore distribution to allow for a simple and accurate method to obtain the fluorescence image without lifetime-extraction for time-resolved fluorescence imaging. An illumination source circuit for TRFI is also disclosed that shapes the excitation pulse. In one embodiment, the illumination source comprises an LED and stub line configured for generating a linear decay profile.

公开(公告)号：US20180303347A1

公开(公告)日：2018-10-25

申请号：US15530266

申请日：2015-06-18

Applicant: The Regents of the University of California

Inventor： Warren S. Grundfest ,  Oscar M. Stafsudd ,  Asael Papour ,  Zachary Taylor

IPC: A61B5/00 ,  G01J3/44 ,  H04N5/33 ,  G01J3/28

CPC classification number: A61B5/0075 ,  A61B5/445 ,  A61B5/4504 ,  A61B5/7282 ,  G01J3/2823 ,  G01J3/44 ,  H04N5/332

Abstract: Systems and methods for biocompatible tissue characterization using Raman imaging are provided. The systems and methods utilize Raman systems tuned to monitor spectral wavelengths characteristic of target types of tissue to monitor constituents of that tissue in biological systems and samples. The Raman systems may be tuned to monitor the Raman signature for the formation of the chemical bonds that join phosphorous and oxygen (PO) atoms, such that the formation of hydroxyapatite may be monitored and used to determine the presence of bone formation in a sample, such as, for example, biological tissue.

公开(公告)号：US20150053871A1

公开(公告)日：2015-02-26

申请号：US14472735

申请日：2014-08-29

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Warren S. Grundfest ,  Oscar M. Stafsudd ,  Pei-Chi Jiang ,  Asael Papour ,  Zachary Deis Taylor

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01N21/6428 ,  G01N21/6447 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/6413 ,  G01N2021/6441 ,  G01N2201/062 ,  G01N2201/0621 ,  G02B21/16

Abstract: A time-resolved fluorescence imaging (TRFI) system that images a target medium without lifetime fitting. Instead of extracting the lifetime precisely, the system images the fluorophore distribution to allow for a simple and accurate method to obtain the fluorescence image without lifetime-extraction for time-resolved fluorescence imaging. An illumination source circuit for TRFI is also disclosed that shapes the excitation pulse. In one embodiment, the illumination source comprises an LED and stub line configured for generating a linear decay profile.

Abstract translation: 时间分辨荧光成像（TRFI）系统，可对目标介质进行成像，而不需要寿命。 系统不仅精确地提取寿命，而且可以对荧光团分布进行成像，以便采用简单而准确的方法获得荧光图像，而无需寿命提取用于时间分辨荧光成像。 还公开了一种用于TRFI的照明源电路，其形成激励脉冲。 在一个实施例中，照明源包括被配置用于产生线性衰减曲线的LED和短线。