公开(公告)号：US20150329583A1

公开(公告)日：2015-11-19

申请号：US14582885

申请日：2014-12-24

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nagichettiar Satyamurthy ,  Jorge R. Barrio ,  Bernard Amarasekera ,  R. Michael Van Dam ,  Sebastian Olma ,  Dirk Williams ,  Mark Eddings ,  Clifton Kwang-Fu Shen

IPC: C07H19/16 ,  B01J19/00 ,  C07D207/46 ,  C07C205/12 ,  C07H3/02 ,  B01J19/12 ,  C07H19/06

CPC classification number: C07H19/16 ,  B01J19/004 ,  B01J19/126 ,  B01J2219/00049 ,  B01J2219/24 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06 ,  Y10T436/115831 ,  Y10T436/12

Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

Abstract translation: 模块化化学生产系统包括从远程位置进行化学反应，特别是放射化学化合物的多个模块。 一个实施例包括一个包括可移动热源的反应容器，其相对于反应容器的位置可从远程位置控制。 或者，热源可以固定在位置，并且反应小瓶可移动进入和离开热源。 反应容器具有一个或多个密封塞，其与反应容器相关的定位可从远程位置控制。 此外，一个或多个反应容器密封塞可以包括一个或多个管道，用于输送反应物，大气压或高压气体，惰性气体，抽真空和从反应小瓶中除去反应终产物， 具有密封塞位置的反应小瓶可在升高的压力下操作。 模块化化学生产系统由模块组装，每个模块可以包括操作状态传感器和配置成用于从远程位置监控和控制各个模块和组装系统的控制器。 其他模块包括但不限于试剂储存和输送模块，滤芯净化模块，微波反应模块，外部QC /分析/纯化界面模块，等分模块，F-18干燥模块，浓缩模块 ，辐射计数模块和毛细管反应堆模块。

公开(公告)号：US09481705B2

公开(公告)日：2016-11-01

申请号：US14941164

申请日：2015-11-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nagichettiar Satyamurthy ,  Jorge R. Barrio ,  Bernard Amarasekera ,  R. Michael Van Dam ,  Sebastian Olma ,  Dirk Williams ,  Mark Eddings ,  Clifton Kwang-Fu Shen

IPC: C07H19/16 ,  B01J19/00 ,  B01J19/12 ,  C07B59/00 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06

CPC classification number: C07H19/16 ,  B01J19/004 ,  B01J19/126 ,  B01J2219/00049 ,  B01J2219/24 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06 ,  Y10T436/115831 ,  Y10T436/12

Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

公开(公告)号：US09211520B2

公开(公告)日：2015-12-15

申请号：US14582885

申请日：2014-12-24

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nagichettiar Satyamurthy ,  Jorge R. Barrio ,  Bernard Amarasekera ,  R. Michael Van Dam ,  Sebastian Olma ,  Dirk Williams ,  Mark Eddings ,  Clifton Kwang-Fu Shen

IPC: G01N31/00 ,  B01J19/12 ,  B01J19/00

CPC classification number: C07H19/16 ,  B01J19/004 ,  B01J19/126 ,  B01J2219/00049 ,  B01J2219/24 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06 ,  Y10T436/115831 ,  Y10T436/12

Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

Abstract translation: 模块化化学生产系统包括从远程位置进行化学反应，特别是放射化学化合物的多个模块。 一个实施例包括一个包括可移动热源的反应容器，其相对于反应容器的位置可从远程位置控制。 或者，热源可以固定在位置，并且反应小瓶可移动进入和离开热源。 反应容器具有一个或多个密封塞，其与反应容器相关的定位可从远程位置控制。 此外，一个或多个反应容器密封塞可以包括一个或多个管道，用于输送反应物，大气压或高压气体，惰性气体，抽真空和从反应小瓶中除去反应终产物， 具有密封塞位置的反应小瓶可在升高的压力下操作。 模块化化学生产系统由模块组装，每个模块可以包括操作状态传感器和配置成用于从远程位置监控和控制各个模块和组装系统的控制器。 其他模块包括但不限于试剂储存和输送模块，滤芯净化模块，微波反应模块，外部QC /分析/纯化界面模块，等分模块，F-18干燥模块，浓缩模块 ，辐射计数模块和毛细管反应堆模块。

公开(公告)号：US20160130295A1

公开(公告)日：2016-05-12

申请号：US14941164

申请日：2015-11-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nagichettiar Satyamurthy ,  Jorge R. Barrio ,  Bernard Amarasekera ,  R. Michael Van Dam ,  Sebastian Olma ,  Dirk Williams ,  Mark Eddings ,  Clifton Kwang-Fu Shen

IPC: C07H19/16 ,  C07C201/06 ,  B01J19/00 ,  C07D207/46 ,  C07B59/00 ,  C07H19/06 ,  C07H5/02

CPC classification number: C07H19/16 ,  B01J19/004 ,  B01J19/126 ,  B01J2219/00049 ,  B01J2219/24 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06 ,  Y10T436/115831 ,  Y10T436/12

Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

公开(公告)号：US09096647B2

公开(公告)日：2015-08-04

申请号：US13924397

申请日：2013-06-21

Applicant: The Regents of the University of California

Inventor： Sebastian Olma ,  Clifton Kwang-Fu Shen

IPC: C07D207/46 ,  C07D207/444 ,  C07K1/13 ,  C07D207/26

CPC classification number: C07K1/13 ,  C07D207/26 ,  C07D207/444 ,  C07D207/46

Abstract: A non-aqueous single pot synthesis of [18F]SFB is set forth. The [18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.

Abstract translation: 阐述了[18F] SFB的非水单锅合成。 然后使用以该方法制备的[18F] SFB，例如以标记化合物作为可注射组合物的代表性实例来标记靶向人表皮生长因子受体2（HER2）的肽或工程改造的抗体片段（双抗体） 使用PET扫描来定位异常组织，特别是动物或人体内的肿瘤。

公开(公告)号：US20130289249A1

公开(公告)日：2013-10-31

申请号：US13924397

申请日：2013-06-21

Applicant: The Regents of the University of California

Inventor： Sebastian Olma ,  Clifton Kwang-Fu Shen

IPC: C07K1/13 ,  C07D207/46

CPC classification number: C07K1/13 ,  C07D207/26 ,  C07D207/444 ,  C07D207/46

Abstract: A non-aqueous single pot synthesis of [18F]SFB is set forth. The [18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.

Abstract translation: 阐述了[18F] SFB的非水单锅合成。 然后使用以该方法制备的[18F] SFB，例如以标记化合物作为可注射组合物的代表性实例来标记靶向人表皮生长因子受体2（HER2）的肽或工程改造的抗体片段（双抗体） 使用PET扫描来定位异常组织，特别是动物或人体内的肿瘤。