公开(公告)号：US20200179927A1

公开(公告)日：2020-06-11

申请号：US16339344

申请日：2017-10-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Jia Wang ,  R. Michael Van Dam

IPC: B01L3/00 ,  B01L7/00 ,  B01J19/00

Abstract: A microfluidic synthesis platform includes a microfluidic chip holder that has a computer controlled heating element and cooling element therein. A microfluidic chip is mountable in the microfluidic chip holder. The microfluidic chip is formed by a hydrophobic substrate having patterned thereon a hydrophilic reaction site and a plurality of hydrophilic channels or pathways extending outward from the hydrophilic reaction site and terminating at respective loading sites on the substrate, wherein the hydrophilic channels or pathways are tapered with an increasing width in an inward direction toward the hydrophilic reaction site. A fixture is provided for holding a plurality of non-contact reagent dispensing devices above the microfluidic chip at locations corresponding to the loading sites of the plurality of hydrophilic channels or pathways, the fixture further holding a moveable collection tube disposed above the hydrophilic reaction site of the microfluidic chip for removing droplets containing reaction products.

公开(公告)号：US10081005B2

公开(公告)日：2018-09-25

申请号：US14777973

申请日：2014-03-26

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Melissa Moore ,  R. Michael Van Dam ,  Kevin Quinn ,  Shane Claggett ,  Henry Herman ,  Mark Lazari

IPC: B01J19/00 ,  B01J14/00 ,  C07H17/02

CPC classification number: B01J19/004 ,  B01J14/00 ,  B01J19/0093 ,  B01J2219/00799 ,  B01J2219/00801 ,  B01J2219/00813 ,  B01J2219/00815 ,  B01J2219/00817 ,  B01J2219/00831 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00909 ,  B01J2219/00918 ,  B01J2219/0097 ,  B01J2219/00986 ,  C07H17/02

Abstract: An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.

公开(公告)号：US09649632B2

公开(公告)日：2017-05-16

申请号：US14406195

申请日：2013-06-10

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： R. Michael Van Dam ,  Gaurav Shah ,  Pei-Yuin Keng

IPC: B01L3/00 ,  G01N35/10 ,  G01N35/00

CPC classification number: B01L3/502753 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2300/0681 ,  B01L2400/0487 ,  B01L2400/0622 ,  G01N35/10 ,  G01N2035/00158 ,  G01N2035/1034

Abstract: The present disclosure sets forth incorporating microfluidic chips interfaces for use with digital microfluidic processes. Methods and devices according to the present disclosure utilize compact, integrated platforms that interface with a chip upstream and downstream of the reaction, as well as between intermediate reaction steps if needed. In some embodiments these interfaces are automated, including automation of a multiple reagent process. Various reagent delivery systems and methods are also disclosed.

公开(公告)号：US20160107951A1

公开(公告)日：2016-04-21

申请号：US14879623

申请日：2015-10-09

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： R. Michael Van Dam ,  Chang-Jin Kim ,  Supin Chen ,  Huijiang Ding ,  Gaurav Jitendra Shah ,  Pei Yuin Keng

IPC: C07B39/00 ,  C07B59/00 ,  C07C227/16 ,  C07D473/18 ,  C07C201/12 ,  C07H1/00

CPC classification number: C07B39/00 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01L3/502784 ,  B01L2300/1827 ,  B01L2400/0427 ,  B01L2400/0487 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/12 ,  C07C227/16 ,  C07D473/18 ,  C07H1/00

Abstract: Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing 18F.

公开(公告)号：US11209390B2

公开(公告)日：2021-12-28

申请号：US16339348

申请日：2017-10-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Noel Seunghyun Ha ,  R. Michael Van Dam ,  Jimmy Ly

IPC: G01N27/447 ,  B01L3/00 ,  G01N27/453

Abstract: A volumetric microfluidic injector for capillary electrophoresis (CE) for highly repeatable sample injection has been designed and built to eliminate known injection bias in hydrodynamic injection. A defined volume from 1-10 nL or 0.1-100 nL of sample is confined in a defined region of a micro-valve PDMS microfluidic injector chip and electrophoretic potential is applied to drive sample into a separation device such as an embedded fused silica capillary for separation and detection. Using a 75 μm ID capillary, the RSD of an absorbance peak area as low as 1.32% (n=11) is obtained. As a comparison, the time-dependent injection was tested using the same chip which resulted in an inferior repeatability.

公开(公告)号：US20160280734A1

公开(公告)日：2016-09-29

申请号：US14777973

申请日：2014-03-26

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Melissa Moore ,  R. Michael Van Dam ,  Kevin Quinn ,  Shane Claggett ,  Henry Herman ,  Mark Lazari

IPC: C07H17/02 ,  B01J14/00

CPC classification number: C07H17/02 ,  B01J14/00 ,  B01J19/004 ,  B01J19/0093 ,  B01J2219/00799 ,  B01J2219/00801 ,  B01J2219/00813 ,  B01J2219/00815 ,  B01J2219/00817 ,  B01J2219/00831 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00909 ,  B01J2219/00918 ,  B01J2219/0097 ,  B01J2219/00986

Abstract: An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.

Abstract translation: 一种自动放射合成装置包括多个反应器组件，每个反应器组件可操作地连接到水平致动器，用于在水平方向上移动反应器组件;以及垂直致动器，用于沿垂直方向移动反应堆组件。 多个一次性盒被设置在多个反应器组件的每一个上方，每个盒包括下表面，该下表面包括多个密封和未密封的垫圈，其中未密封的垫片连接到盒内的内部流体路径。 该装置包括三轴试剂和气体处理机器人，其设置在多个盒的上方并且终止于小瓶夹持器和具有惰性气体端口和真空端口的气体歧管。 该装置包括控制系统，其配置成控制每个反应器组件和三轴试剂和气体处理机器人的水平致动器和垂直致动器。

公开(公告)号：US20160130295A1

公开(公告)日：2016-05-12

申请号：US14941164

申请日：2015-11-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nagichettiar Satyamurthy ,  Jorge R. Barrio ,  Bernard Amarasekera ,  R. Michael Van Dam ,  Sebastian Olma ,  Dirk Williams ,  Mark Eddings ,  Clifton Kwang-Fu Shen

IPC: C07H19/16 ,  C07C201/06 ,  B01J19/00 ,  C07D207/46 ,  C07B59/00 ,  C07H19/06 ,  C07H5/02

CPC classification number: C07H19/16 ,  B01J19/004 ,  B01J19/126 ,  B01J2219/00049 ,  B01J2219/24 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06 ,  Y10T436/115831 ,  Y10T436/12

Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

公开(公告)号：US11383235B2

公开(公告)日：2022-07-12

申请号：US16339344

申请日：2017-10-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Jia Wang ,  R. Michael Van Dam

IPC: B01L9/00 ,  B01L3/00 ,  B01J19/00 ,  B01L7/00

Abstract: A microfluidic synthesis platform includes a microfluidic chip holder that has a computer controlled heating element and cooling element therein. A microfluidic chip is mountable in the microfluidic chip holder. The microfluidic chip is formed by a hydrophobic substrate having patterned thereon a hydrophilic reaction site and a plurality of hydrophilic channels or pathways extending outward from the hydrophilic reaction site and terminating at respective loading sites on the substrate, wherein the hydrophilic channels or pathways are tapered with an increasing width in an inward direction toward the hydrophilic reaction site. A fixture is provided for holding a plurality of non-contact reagent dispensing devices above the microfluidic chip at locations corresponding to the loading sites of the plurality of hydrophilic channels or pathways, the fixture further holding a moveable collection tube disposed above the hydrophilic reaction site of the microfluidic chip for removing droplets containing reaction products.

公开(公告)号：US09481615B2

公开(公告)日：2016-11-01

申请号：US14879623

申请日：2015-10-09

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： R. Michael Van Dam ,  Chang-Jin Kim ,  Supin Chen ,  Huijiang Ding ,  Gaurav Jitendra Shah ,  Pei Yuin Keng

IPC: B01L3/00 ,  C07B39/00 ,  C07C201/12 ,  C07H1/00 ,  C07C227/16 ,  C07D473/18 ,  C07B59/00

CPC classification number: C07B39/00 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01L3/502784 ,  B01L2300/1827 ,  B01L2400/0427 ,  B01L2400/0487 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/12 ,  C07C227/16 ,  C07D473/18 ,  C07H1/00

Abstract: Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing 18F.

公开(公告)号：US20150329583A1

公开(公告)日：2015-11-19

申请号：US14582885

申请日：2014-12-24

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nagichettiar Satyamurthy ,  Jorge R. Barrio ,  Bernard Amarasekera ,  R. Michael Van Dam ,  Sebastian Olma ,  Dirk Williams ,  Mark Eddings ,  Clifton Kwang-Fu Shen

IPC: C07H19/16 ,  B01J19/00 ,  C07D207/46 ,  C07C205/12 ,  C07H3/02 ,  B01J19/12 ,  C07H19/06

CPC classification number: C07H19/16 ,  B01J19/004 ,  B01J19/126 ,  B01J2219/00049 ,  B01J2219/24 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06 ,  Y10T436/115831 ,  Y10T436/12

Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

Abstract translation: 模块化化学生产系统包括从远程位置进行化学反应，特别是放射化学化合物的多个模块。 一个实施例包括一个包括可移动热源的反应容器，其相对于反应容器的位置可从远程位置控制。 或者，热源可以固定在位置，并且反应小瓶可移动进入和离开热源。 反应容器具有一个或多个密封塞，其与反应容器相关的定位可从远程位置控制。 此外，一个或多个反应容器密封塞可以包括一个或多个管道，用于输送反应物，大气压或高压气体，惰性气体，抽真空和从反应小瓶中除去反应终产物， 具有密封塞位置的反应小瓶可在升高的压力下操作。 模块化化学生产系统由模块组装，每个模块可以包括操作状态传感器和配置成用于从远程位置监控和控制各个模块和组装系统的控制器。 其他模块包括但不限于试剂储存和输送模块，滤芯净化模块，微波反应模块，外部QC /分析/纯化界面模块，等分模块，F-18干燥模块，浓缩模块 ，辐射计数模块和毛细管反应堆模块。