公开(公告)号：US12018135B2

公开(公告)日：2024-06-25

申请号：US17336766

申请日：2021-06-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Herbert B. Scher ,  Scott Strobel ,  Tina Jeoh Zicari ,  Dana Wong

IPC: C08J3/24 ,  B01J13/04 ,  B01J13/14 ,  C08K3/16 ,  C08K3/28 ,  C08K5/095 ,  C08K5/5357

CPC classification number: C08J3/24 ,  B01J13/043 ,  B01J13/14 ,  C08K3/16 ,  C08K3/28 ,  C08K5/095 ,  C08K5/5357 ,  C08J2305/04 ,  C08J2305/08 ,  C08K2003/162

Abstract: Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously.

公开(公告)号：US20220025132A1

公开(公告)日：2022-01-27

申请号：US17336766

申请日：2021-06-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Herbert B. Scher ,  Scott Strobel ,  Tina Jeoh Zicari ,  Dana Wong

IPC: C08J3/24 ,  B01J13/04 ,  B01J13/14 ,  C08K5/5357 ,  C08K3/16 ,  C08K3/28 ,  C08K5/095

Abstract: Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously.