公开(公告)号：US20220025132A1

公开(公告)日：2022-01-27

申请号：US17336766

申请日：2021-06-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Herbert B. Scher ,  Scott Strobel ,  Tina Jeoh Zicari ,  Dana Wong

IPC: C08J3/24 ,  B01J13/04 ,  B01J13/14 ,  C08K5/5357 ,  C08K3/16 ,  C08K3/28 ,  C08K5/095

Abstract: Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously.

公开(公告)号：US20170333360A1

公开(公告)日：2017-11-23

申请号：US15615520

申请日：2017-06-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tina Jeoh Zicari ,  Herbert B. Scher ,  Monica C. Santa-Maria ,  Scott Strobel

IPC: A61K9/50 ,  A61K38/38 ,  A61K47/30 ,  B01J13/04 ,  C08J3/24 ,  C08J3/12 ,  A61K38/47 ,  A61K9/16

CPC classification number: A61K9/5036 ,  A61K9/1694 ,  A61K9/5089 ,  A61K38/385 ,  A61K38/47 ,  A61K47/30 ,  B01J13/043 ,  B01J13/046 ,  C08J3/122 ,  C08J3/24 ,  C08J2305/04 ,  C08J2305/06 ,  C08J2389/00 ,  C12Y302/01004 ,  C12Y302/01008

Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.

公开(公告)号：US09700519B2

公开(公告)日：2017-07-11

申请号：US14288110

申请日：2014-05-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tina Jeoh Zicari ,  Herbert B. Scher ,  Monica C. Santa-Maria ,  Scott Strobel

IPC: A61K9/50 ,  A61K31/734 ,  A61K47/30 ,  A61K9/16 ,  B01J13/04 ,  C08J3/12 ,  C08J3/24 ,  A61K38/38 ,  A61K38/47

CPC classification number: A61K9/5036 ,  A61K9/1694 ,  A61K9/5089 ,  A61K38/385 ,  A61K38/47 ,  A61K47/30 ,  B01J13/043 ,  B01J13/046 ,  C08J3/122 ,  C08J3/24 ,  C08J2305/04 ,  C08J2305/06 ,  C08J2389/00 ,  C12Y302/01004 ,  C12Y302/01008

Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.

公开(公告)号：US12018135B2

公开(公告)日：2024-06-25

申请号：US17336766

申请日：2021-06-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Herbert B. Scher ,  Scott Strobel ,  Tina Jeoh Zicari ,  Dana Wong

IPC: C08J3/24 ,  B01J13/04 ,  B01J13/14 ,  C08K3/16 ,  C08K3/28 ,  C08K5/095 ,  C08K5/5357

CPC classification number: C08J3/24 ,  B01J13/043 ,  B01J13/14 ,  C08K3/16 ,  C08K3/28 ,  C08K5/095 ,  C08K5/5357 ,  C08J2305/04 ,  C08J2305/08 ,  C08K2003/162

Abstract: Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously.

公开(公告)号：US20220105487A1

公开(公告)日：2022-04-07

申请号：US17501745

申请日：2021-10-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Scott Strobel ,  Herbert B. Scher ,  Tina Jeoh Zicari

IPC: B01J13/14 ,  C08L5/04 ,  C08L3/06 ,  C08K5/09 ,  B01J13/04 ,  C08K3/28

Abstract: Systems and methods are provided for microencapsulating oxygen sensitive cargo such as polyunsaturated fatty acids and other oils by spray drying with an in situ internal gelation mechanism achieving cross-linking of polymers during the process, which is well-suited for industrial scale-up. Spray drying formulations of a mixture of an immiscible hydrophobic cargo and an emulsifier of a hydrophobically modified hydrophilic polymer with a suspension of a multivalent ion cross-linkable polymer, at least one acid, at least one volatile base and at least one salt of a multivalent ion can be adapted to provide control over particle size, degree of crosslinking, enteric release of cargo and shelf life. The methods produce microcapsules that enhance the shelf life of lipophilic bioactives while providing a mechanism of gastrointestinal delivery.

公开(公告)号：US20140348815A1

公开(公告)日：2014-11-27

申请号：US14288110

申请日：2014-05-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tina Jeoh-Zicari ,  Herbert B. Scher ,  Monica C. Santa-Maria ,  Scott Strobel

IPC: A61K9/50 ,  A61K38/47 ,  A61K47/30 ,  A61K38/38

CPC classification number: A61K9/5036 ,  A61K9/1694 ,  A61K9/5089 ,  A61K38/385 ,  A61K38/47 ,  A61K47/30 ,  B01J13/043 ,  B01J13/046 ,  C08J3/122 ,  C08J3/24 ,  C08J2305/04 ,  C08J2305/06 ,  C08J2389/00 ,  C12Y302/01004 ,  C12Y302/01008

Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.

Abstract translation: 提出了生物活性和化学货物在稳定的交联聚合物基质中的微胶囊化，其导致小的颗粒尺寸并且易于放大用于工业应用。 酸溶性多价离子盐，用挥发性碱中和的酸和在多价离子存在下交联的一种或多种单体的配方被雾化成液滴。 交联是在雾化时实现的，其中挥发性碱被汽化，导致制剂的pH降低，并且多价离子从与形成胶囊的单体交联的盐的时间释放。 在制剂中加入另外的聚合物或疏水性化合物可以控制颗粒的水合性质以控制包封的化合物的释放。 还可以控制操作参数以影响胶囊性质，例如粒度和粒度分布。