公开(公告)号：US20190142965A1

公开(公告)日：2019-05-16

申请号：US16092202

申请日：2017-04-10

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tatiana Segura ,  Donald Griffin ,  Philip Scumpia

IPC: A61K47/69 ,  A61K47/60 ,  A61P17/02 ,  A61K39/39 ,  A61K38/06 ,  A61K38/48 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12

Abstract: An immune-modulating biomaterial comprising a hydrogel scaffold coupled to D-amino acid containing peptides having unexpected properties in vivo is described. For example, certain inflammatory reactions in vivo are significantly increased around the D-peptide containing particles of hydrogel scaffold as compared to particles that contain both L and D peptides or L peptides alone. In addition, these D-peptide compositions are further observed to enhance wound healing and improve the tensile strength of healed tissues. For these and other reasons, the D-amino acid hydrogel materials disclosed herein are useful in a number of methodologies that seek to modulate the immune response and/or wound healing.

公开(公告)号：US20200305773A1

公开(公告)日：2020-10-01

申请号：US16071252

申请日：2017-01-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Dino Di Carlo ,  Westbrook Weaver ,  Donald Griffin ,  Jaekyung Koh

IPC: A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/1459 ,  A61B5/1455

Abstract: A biocompatible analyte sensing material for intradermal or subcutaneous application includes a collection of microgel particles having one or more network crosslinker components and an endogenous or exogenous annealing agent that links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. A plurality of analyte-specific fluorophores are conjugated to the microgel particles, wherein the analyte-specific fluorophores, in the presence of the analyte and subject to excitation radiation, emit fluorescent light. The analyte sensing material may, in some embodiments, be applied to an excision made in the skin or injected into the skin of a subject.

公开(公告)号：US10849988B2

公开(公告)日：2020-12-01

申请号：US16092202

申请日：2017-04-10

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tatiana Segura ,  Donald Griffin ,  Philip Scumpia

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K47/69 ,  A61K39/39 ,  A61L27/38 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61L27/50 ,  A61L26/00 ,  A61L27/20 ,  A61L27/52 ,  A61L27/56 ,  A61K47/60 ,  A61P17/02 ,  A61K38/06 ,  A61K38/48 ,  A61K39/02

Abstract: An immune-modulating biomaterial comprising a hydrogel scaffold coupled to D-amino acid containing peptides having unexpected properties in vivo is described. For example, certain inflammatory reactions in vivo are significantly increased around the D-peptide containing particles of hydrogel scaffold as compared to particles that contain both L and D peptides or L peptides alone. In addition, these D-peptide compositions are further observed to enhance wound healing and improve the tensile strength of healed tissues. For these and other reasons, the D-amino acid hydrogel materials disclosed herein are useful in a number of methodologies that seek to modulate the immune response and/or wound healing.